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Massive news for sure. The hope is now they translate this to other forms of sensorineural hearing loss successfully. It's very welcome as things have been so bleak on the hearing loss front since the Frequency Therapeutics shitshow.

Thanks, I still remember the one or two who notoriously disagreed with me in this thread earlier on (as I personally lost faith in this drug during the initial Phase 2 readout) but there is no point in a "told ya so" approach because we're all losers in the grand scheme of things with this...

Gradually - left-sided hearing loss that has progressed to severe/profound across its entire range. My right ear is almost fully in normal range, I'll only consider a cochlear implant if my right (good) ear can't hack it anymore either and/or future iterations of a cochlear implant are...

Is your hearing loss in both ears or just one? I have been told I have a case for being a cochlear implant candidate for my left ear (basically severe-profound across the board on that one). My right ear is normal with just a 25 dB dip at 4 kHz at worst, which is why I have not bothered...

Well that's the end of that journey. I came back onto Tinnitus Talk in 2018 after my left ear went from moderate-severe to severe-profound hearing loss, and FX-322 was still in its early days of being announced. I think the lessons I learnt are as follows: 1. Joining online tinnitus...

Mmmm, another day closer to celebrating recognising words rather than the vast majority of sounds in the wide range/spectrum of sound frequencies Don't get me wrong, I don't take joy in being some kind of party pooper or being negative, in fact I am rooting for Frequency Therapeutics (and...

Careful, the shills on copium don't like audiograms here.

As crazy to think or say but quite probably the only thing I would say is a positive about the pandemic/COVID-19 is the extra spotlight on tinnitus/hearing loss as an issue because of it.

This is fair but considering your competition (Otonomy) has trademarked a specific delivery and gel formulation you'd think they'd know this is a problem and performance indicator they needed to tackle before even starting their Phase 2's that have all brought very very minor results. I hope I...

The stock price reflects everything you need to know. Frequency Therapeutics to date has been nothing but promises dwindled and watered down again and again - they have been transparent I'll give them that but it's this very transparency (mostly redacting their expectations) when other...

Nah, there's far more to hearing than just human speech. Pure Tone Average might not mean much to you but that is most definitely not the case for those of us with deeper and wider losses on the audiogram. Certainly more than just a few "generated beeps" It's fair to say this drug continues to...

I don't regularly post on here anymore by the way because it doesn't really bring on anything and I can't be bothered reading walls of texts by people, who despite their best intentions, have nothing to do with the development of the drug or the trials whatsoever nor do they have any...

Flattered you had to stalk and amused that's all you got out of it. Clearly logged in to see if there was a rational response to me. There wasn't ;) Ciao ciao.

When I initially got attached to FX-322, it wasn't for the notion of "improved word scores" and improvements in the super high frequencies. It was for a potentially effective hearing loss treatment. Like actual restoration that is evident on an audiogram for those of us, like me, have hearing...

Hello my friend, I developed tinnitus back in 2009 when I was just 17, entering adulthood and just about to start my life. My passion has always been music production and playing music. I went on and did it with one good ear, which is still my normal ear to this day. The left one is now in the...

It's not as unusual as you might think (link below). My left ear is practically flat across the severe/profound. Obviously the first port of call was an MRI which came back normal at the time. I have also come across a research paper that indicates that it's not out of the norm to have one ear...

For sure, I have had better hearing and quieter tinnitus during past audiograms not as bad as my current one. My hearing got progressively worse over a decade and the only thing I can think of is noise damage as I am involved in music and a lot of loud environments / headphone use. It stayed at...

Thank you for saying this. So tired of reading "audiograms mean nothing" by people with losses in the super high frequencies/hidden hearing loss or even one single minor loss at one frequency. I have losses in all frequencies in the severe/profound range, audiograms and their results do matter.

I think even the most optimistic of optimists can agree that these guys have one more major trial ahead of them to really get an idea of what to expect out of this. Whether it's study design, drug delivery, higher dose in a single shot etc. Is there much hope? I would say the same level of hope...

Just finished reading through the last few pages. Seems like the people who still have faith and optimism are holding out hopes for better and more controlled future studies, a better delivery, getting more out of a single injection dose etc. The single injection dose improvement on an...

#wait

This is really some thread now. We got hypothesis in abundance, repeated questions, doomsayers, optimistists, stock market "experts", reassurance seekers and memes for good measure. Will I still be here for the next 2-3 years until this medication comes out? Probably. Like a girl/guy you know...

Yes that's right, I live in Newcastle, although I've been all over the place here. Born and raised in the Middle East (Bahrain) but lived in England for the last decade. Of course I know where that is, it's where all the farmers live haha. I have not been to Ipswich or Norwich but do know some...

Thank you and death to SpongeBob.

She just stands there staring at me every time I have food I'm about to eat haha. "Where's mine?"

On its own, probably not. However, if we all get lucky with this working and some of the other biotechs treatments work for the other stuff + advancements in other related areas., we might have a combination of treatments to bring a close to total relief within 5-10 years I think. Big ifs but...

I'd gladly watch that movie everyday of my life for an end to this shit hahahaha.

Cat ready to risk it all... Think someone's been reading too many Garfield comic strips.

But wait there's more... #8k+hairsmatter

We're gonna have to meme our way to the results boys.

I think someone posted a few weeks ago they were hiring an intern for drug delivery as well, it was in their job listings. It does seem like they are working on better delivery methods for the future.

This is exciting but also not something I'm as keen on in comparison to non-surgical treatments for the inner ear. I hope one or more of the current crop of treatments in research for hair cell regrowth works to show the way that regenerative biology works and is the way forwards rather than...

I got in touch, they weren't taking Meme Consultants on unfortunately.

Bit different from what's being posted but I am a massive electronic music nut - Progressive House especially. This guy is my favourite. Bit of a cheat post as its more of a set rather than one song.

Okay one last one...

Know your worth KINGS (and Queens).

There were no hair clippers or weapons of mass destruction to be found in sight.

I see all you guys showing your lockdown/pandemic hair. I went between two looks mostly during this time The Saddam and the Squidward.

My grandfather died in his 80s and had bad enough hearing loss in both ears. Cognitive ability was fine. I agree with the point of correlation =/ causation.

Not everyone's hearing is the same dude, literally a genetic lottery. Not a chance worth taking. Better safe than sorry.

30 dB at one frequency is not even classed as clinically significant, although it is technically a minor hearing loss at that frequency. Thank your lucky stars it's not worse and look after your hearing from this point onwards. As for the girl, she's clueless. Music actually sounds better with...

Don't worry too much, everything under 25 dB is technically classed as "normal" - the best you can do is make sure you don't ever forget wearing earplugs ever again and fuck what people think, you only have one shot at keeping the hearing you have, wear earplugs. As for 30 dB, that's the very...

Missing summer and travel...

What I do wonder is, if this drug does indeed work for the severe range and not profound due to lack of support cells, does the drug still regenerate hair cells in the profound range if there are enough support cells in "better hearing" areas of the cochlea? Or will it only regenerate the ones...

My right ear is normal but my left ear is in the severe/profound range. This is really interesting. Still not something I would consider doing because surely doing so would mean any chance of potential treatments coming in the next years are going to be ineffective for me as a result? My ideal...

Never said it was. It's already common knowledge it's not the only cause of tinnitus. Cigs have been shown to have a link (poison) to effects on the inner ear. I don't believe antidepressants have though. If you can link me direct evidence/research that would be great. From my understanding...

I think it's mostly certain antibiotics, chemotherapy treatments etc. The list of things that can make tinnitus worse or induce tinnitus are however the vast majority in comparison but that doesn't mean hair cell death. Risk vs. Benefit is purely down to what the person sees as a bigger issue...

They don't. I wish people would stop calling them ototoxic as well. I remember a Doctor in the Doctor's Corner section (one with tinnitus himself) and a tinnitus expert clarified that antidepressants aren't ototoxic. Drugs that are actually ototoxic (i.e - cause hair cell death) are actually...

FDA, CDC, MSNBC, Frequency Therapeutics... COME ON BOYS, HURRY UP.

@Jrblovsky, I saw you mentioned suffering with OCD. Are you taking any meds for it, if so, which one and do you find it helps?

I read one of his interviews and the categories he puts certain tinnitus patients under and it just screams - wow, you really underestimate and undersell the suffering of those who have severe cases of this, don't you? Sounds like he needs a good slap, he'd be quite receptive to it I think. I...

This is me (and my bad ear, shit I've just noticed that) probably in tinnitus jail or something.

I really hope the message gets across to him how useless and counterproductive he's been to the tinnitus community. It's all well and good people complain about it on here but I wish somehow people let him know themselves. Spending money and working on changing "perceptual awareness" is not a...

I wouldn't worry about that too much man, I am pretty certain that it's the same reason certain people have hearing loss and tinnitus but not hyperacusis (I am in that category, zero hyperacusis but I have visual snow and tinnitus with my hearing loss). I just think the symptoms of manifestation...

Nah, I would wager that your visual snow is directly linked to the trauma in your cochlea. Funnily enough, I met an Otologist recently who knows perfectly well about visual snow (rather than the usual "what's that? never heard of it" shit), which took me by surprise. Visual snow is a symptom of...

Yeah, I couldn't handle the first week second time around. I'm okay with meds for now.

Hi mate, not on Venlafaxine anymore. Initially I was on it for 4 months but couldn't notice it doing much, I could have upped the dose but decided to drop it. Side effects more or less subsided around about one month in. Not currently on any medications.

Just hoping to ask if anyone knows the answer as I'm a bit at my wits' end (and at the point of just giving up on hearing restoration at all for my bad ear), seeing as FX-322 works on support cells potentially up to severe damage... now for those with a severe to profound hearing loss - would...

I had some bad news yesterday. It would seem my bad ear is in the severe to profound range now. Hopefully FX-322 shows efficacy for severe hearing loss. Which I think would probably mean FX-322 might be partially effective to not effective at all for me. Fingers crossed its the former and not...

I'ts fantastic, let's be honest, FX-322 coming out this year was extremely wishful thinking. 2 years is nothing when you consider that we're very close from seeing how efficient it is and if that's all with flying colours, that motivation alone can carry us through to 2023. When you look at how...