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This question may sound silly, but it brings up an interesting idea. What if there were a combination of questions one could answer that would demonstrate to the world how impactful this condition is? I think the Tinnitus Quest team would also like to see such a “live” questionnaire being...

Tinnitus Quest is a great initiative. Currently, there is practically ZERO representation of the hearing loss/tinnitus population (ATA is a joke, in my view), and if Tinnitus Quest could reach out to the world, that would be fantastic! I think there is also a lack of communication between...

I don’t think that their procedure is more complicated than a cochlear implant surgery, which is pretty much outpatient. They want to be able to accurately deliver the drug via the round window, therefore I think they will cut behind the ear and to it like that, or perhaps they will make a...

How common would it be for someone to have damaged potassium channels? I would imagine that is something like stroke or genetic mutations? I mean if someone would have their potassium channels damaged, then Trobalt would not work for epilepsy either. I don’t think that an acoustic trauma can...

Okay, so here is my problem with it: what does “nerve loss” mean? Like you have totally fine outer hair cell & inner hair cell situation in cochlea, and all of a sudden the nerve bundle between the cochlea and the brain gets damaged? Is this what they mean? I find this extremely unlikely to be a...

Can you or @ErikaS share a link for the trial's contact information, please? I cannot find it on the web. Ty!

I live in NYC. Could I try to enroll in the trial?

The device needs to be used constantly, until something can regenerate the hearing damage somehow. I see what you are saying though.

If I am reading it right, the majority saw improvements, very little worsening overall and we don’t really know what these worsening are from anyways (could be something else). Trying to correlate epilepsy with tinnitus, and if the drug takes about equal time to work on both epilepsy and...

This definitely sucks but I was sure of them denying the request (unfortunately). They are definitely not planning on trialing this on anything BUT what they know this will work on. Even if they have people with tinnitus in the trial being treated for epilepsy and they report positive effect on...

It would be nice to also know how much of a reduction (subjective of course) he got? I read that people's tinnitus got eliminated while on Trobalt.

My understanding is that you won’t see/can’t search submissions, but only approvals? Basically I thought stuff gets listed after approval.

We have had comments here from folks whom are involved with FDA/pharma in their professional lives and the 6 month time frame for this device to be potentially approved is very much realistic. ENT/audiology training is most likely going to be online which will help to expedite the process...

Lenire is pretty much hot garbage. Neuroplasticity is something that humans lose with time but slightly, otherwise you would never be able to learn anything new at an older age which isn’t true. And, if Dr. Susan Shore is correct about us basically having misfiring neurons - all we need to do...

Are you sure that the LEDs in these are strong enough?

We are all speculating here about Auricle's progress with FDA and other things. It's definitely at snail's pace and not as fast as we all would like. If they know what they are doing - the device could be out in ~2 years. Production takes time - you will be surprised how quickly this stuff can...

Well, we know that Trobalt was hit & miss because of it not being all that potent. But for some folks it was potent enough. I hope that efficacy of XEN1101 and/or BHV-7000 will be enough to help even more people. I tend to agree with the comments about some drugs having positive effects on...

Well, by the looks of it, the device does work. Now, they obviously know more than we do about it, and if it is all that promising, then they are going to hide as much as they can before going to market with it. Imagine this: you got something developed and tested, based on your testing it does...

Perhaps chaos in DCN causes visual snow? I have it too and never had prior to getting tinnitus.

They state in the article that there is restorative gene therapy available and it costs nearly $800k? Is that accurate? As far as we know, there isn’t regenerative therapy available yet.

It looks like XEN1101 doesn't have Retigabine's side effects because of how specific and potent it is. So I would say the chances are if XEN1101 works for tinnitus, then it may also resolve visual snow syndrome.

Guys, if you want any benefit from this at all - use isolate only. Stuff sold at the stores has nowhere near declared amount of CBD and that is what differentiates CBD isolate self-made tinctures and/or Epidiolex; the concentration and purity of CBD. A week's supply of CBD isolate, as per 10...

I have a hard time believing in “hey, watch what we have discovered and made work” type of information being published just like that without a ready product for manufacturing and distribution, unless some key points won’t be disclosed? I mean think about it: Dr. Shore had somehow her research...

Well, because a few things: 1) Poorly designed original testing 2) If FX-322 is restoring any hearing, it is in 10 kHz+ range. It seems like clarity in hearing is in 8 kHz+ in addition to aid in helping hearing in noisy environments and this is what they were able to find out. This is why they...

Gotcha, but what would prevent someone in Mainland China for example cloning Dr. Shore’s device and sell it on AliExpress? US laws don’t spread everywhere and I do think they are considering this. Look man, we still have no idea if Dr. Shore’s device even remotely works for sure. No results and...

Well, this is not just about what University of Michigan wants to associate itself with and such, it is also about the commercialization portion. I can see this going two ways: Way 1: Last phase with more patients did not prove what smaller study had pointed out to. Way 2: Last phase did...

I haven’t found the mechanism of action on their drugs but within their tech page they are talking about p27Kip1 that apparently does signal cochlear hear cells and supporting cells to regenerate. They also claim that p27Kip1 is responsible of regeneration of some other tissues as well. With...

Based on what I get from Frequency Therapeutics' comments, scheduling is what they are also trying to figure out for future trials. Carl LeBel mentioned that they have identified what seems to be people having “their own unique timeframe” to respond. What I am thinking is that if birds...

Hey OP, I feel your struggle. I myself am in the same spot with worsened tinnitus in my left ear from ear syringe/reflex test. I have tinnitus in both ears but it used to be mild, now my left ear is what I would call as moderate. Hissing is louder then before in that ear :( All I am hopeful...

Honestly, barely noticeable is all what most with tinnitus need. When people say barely noticeable, it is when they are in a quite room and need to “listen” for it. Lmao if that were most of us with tinnitus, this forum would not even exist. Who knows, maybe this decade is the last one anyone...

Might be financial. Perhaps they want avoid leaking any info on efficacy of their drug? If results would be not so great and info would leak - their stock would drop like it did with FREQ. Just my thoughts here, I obviously could be wrong.

Hey @Warchop, thanks for your reply! Perhaps she figured out some sort of “norm” to which her device brings auditory cortex to? (Or at least is aiming to)? I mean think about it, if there is “a” state of auditory cortex which is “normal” and “b” state which is “altered”, perhaps she figured out...

Hey everyone! Question here. I have done an audiogram last week due to a spike in my left ear and feeling that I hear worse from it than from my right ear. The standard audiogram up to 8 kHz does not show any measurable hearing loss. What is weird is that it definitely feels like my left ear...

He states that neurons cannot be fixed - wrong. They are just slow to regenerate naturally and we need drugs that can speed regeneration. That being said - if this is like Neuralink, it may have cool applications.

I crave silence a lot as well, as do many others. People don’t realize how important silence is, until they lose it. Some get a valuable lesson when they get tinnitus for a few days after a concert or whatnot and learn from there. Some ignore it until it’s too late. I wish that someone would...

To add: poor people in Ukraine and Russia. Now a lot more people will suffer consequences of war; death, injuries, hearing loss, tinnitus...

Lmao.

Why would this meeting would be “behind closed doors” without any recording whatsoever? I am surprised that there was no livestream...

Well, perhaps this trial is designed to be as accurate as possible? Dr. Susan Shore seems like a person that would sacrifice time to make things more accurate for the sake of science. I mean, if not for the person whom setup Auricle, she may still be just doing research and she would have her...

Theoretically, if tinnitus is eliminated - so will visual snow caused by hyperactivity in auditory cortex. It seems like the brain has some degree of ability to mitigate “noise”. If all of these “theoretical treatments” will “cancel” out tinnitus, then, with time, plasticity of the brain will...

Yea, few things I wonder: a) their results are good and they are taking their time with not leaking any information so that no one copies their approach/device before they hit the “shelves”. b) their results are not so good due to either bad trial setup or how quickly result wearers off and how...

Where did you find that? If I follow your link, it doesn’t even list Susan Shore under keynote speakers. Ehhh... I wish this device/approach could silence tinnitus, I really do. But this whole thing with delays and extensions with FDA/clinical trials is just very downing.

I don’t want to be overly pessimistic, but this thread started around 10 years ago (a fkn decade!) and Dr. Shore is yet to release any information on her research. I am sure that she is WELL AWARE that there are millions of people in the US alone that would do a lot to get rid of their tinnitus...

Do we know why? I mean, based on the description this may allow them delay submission for up to TWO years! This is probably going nowhere :(

Did you end up using the drops? I got prescribed same drops. Please let me know!

Hi Rhea, Ohh I can relate. I had somewhat habituated 5 years ago (about a year after my tinnitus onset) and now I am on square one. I did have little spikes here and there but nothing major. I got sick with COVID-19 in January and it definitely worsened my tinnitus. I also got ear infection...

This whole idea with modulating neurons in auditory cortex makes a lot of sense and it is great to hear that Dr. Shore has engineer-like approach to this. She does emphasize that this isn’t like “let’s just try and see if it works”, rather she definitely figured out how to influence auditory...

No, you are right. But hear me out - the tech wasn’t really there yet. Now it is. There is even a machine learning algorithm that apparently was able to “calculate” new type of antibiotic that no bacteria can develop resistance to. All I am saying is that issues with hearing is becoming a more...

Hey! First of all - we all understand you pretty well here (more or less). Could it get better - yes. Will it? Depends, but most of the time it does get better. How much better - no one can tell. I wish that we could give you more of a scientific answer here, but it is mainly speculation here...

@MiaX because they are visible from the side, but classic foam earplug should not stick out nor be visible from the front (looking straight at face). We are talking about how to make it COMPLETLEY invisible and "vanish" - this os why you would cut out 1/4 of OUTTER side. I do this all the time...

@Ian Mac ohh man, sorry to hear that. No sh*t that sucks. I though it felt much better when they did shots ? F*ck dude, sad to hear :/

@MiaX occlusion effect is miminal to non when foam earplugs are used. This is because gap between earplug and eardrum is small (imagine yourself in small room with closed door: if you yell - no echo, right ? There is no "space" for sound to rezonate. Now try to go to cave and yell - bunch of...

I am glad to see that you are enjoying yourself, despite having T. Now, you have 25 dB custom earplugs and you wore them whole night. Were you having conversations during time you were wearing them? Since you could not hear radio over voices which means you would not hear other people well and...

I wanted to add: just catched a spike in my right ear. Every now and then i get one, interrestigly enough during the day its one of these few secods "eeeee" and goes back however, if it is at night - it can last a bit. P.S. Has not been riding for a few weeks now, not sure it can be related to...

I have T for 1 year and 3 Months. Two months ago i bought Ducati Monster 796 ABS and am riding quite often. I generally never go beyond 65 mp/h, however i ALWAYS put my Howard Leight MAX 34 DB NRR (Orange ones, with larger outter side). On top of that, i wear Schuberth S2 Sport which they rate...

@amymilly first of all - damn you pretty and congratulations. I own ACS custom earplugs - they are greqt however, try not to talk or do so quietly without raising voice. Reason for it - occlusion effect. I have been in situation where i wore them and was speaking loud and stuff - my ears would...

Hey, yes you are correct. I mean safety raiting on earplugs is limited to their spescifications, i would not look for anything beyond that (regards 75Hz bass, i think you need to add some sort of "metal" filling to foam earplug to bounce that off), however if used properly - they work. I can...

Idk but i got used to foam and they are superrior to custom molds by amount of benefits you get, not mentioning price. Now, i have both ACS Custom ones with set of filters (pro 17 and pro 26) and i tell ya - foam is much better. I literally cannot talk when in ACS plugs. Oclusion effect...

How can you damage eardrum with FOAM earplug if not worn for hours ? Its easy so feel how close it is and you do same with reg foam earplug, no difference.

100% i use my earplugs on daily basis. Beleive me, get foam ones, cut quarter off on outter side and put them all the way in (almost touching eardrum, but not) and try to talk - will be amaized, world of difference. P.S. make sure you have twizers or someth8ng like that to take them out. Take...