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Well that explains why Jamaican sprinters are consistently the fastest in the world. They learn that if they don't run fast to get away, it's highly likely they're gonna get killed! Just a theory. ;)

The man believes that dinosaurs were on Noah's Ark. He has interests in theme park museums in Kentucky, where school children pull up in yellow buses, shuffle in and are taught creation theory. He thinks the world should be run along biblical lines. His first order of business was to arrange...

Hi @Chris Fraser I am very sorry to read your story. Your tinnitus sounds quite severe, exacerbated by significant hearing loss. Hearing loss contributes to tinnitus severity because of the loss of ambient sound input to the brain. You're grieving too. How can you not, when you've been slugged...

:bored: That's my argument here. Dr. Shore has taken the seven year (and probably will be longer) route, rather than the three year one. I don't believe the earth is flat or that the moon landing was fake. Just that she's taken a long and not particularly efficient road to get to the point...

She should have sought a commercial partner after her successful results following the trial you were involved in. There'd have been a few takers considering the positive results she achieved. She's only just announced one recently. She's dawdled alright. No rush. Compare Frequency Tx to Dr...

You're very generous to Dr. Shore. That's fine, but really if your timeline for a two phase trials process is stretched out to nearly ten years, chances are very good that your going to hit all your timelines riding that tortoise as hard as you can. You've got to admit, she's taken her own...

I have taken a course of a cephalosporin antibiotic called cefalexin. I don't know if it's prescribed for tooth infections, but it has never caused any problems for my ears. Perhaps that's one you could explore.

Oh really Dr. Shore! You're going extend the distance from your testing site? In another trial maybe? Another two years down the road? How lovely! We're all so terribly excited. No need to rush now. Isn't permanent tenure just so peachy?!

Why, you call him on his... shell phone, of course!

Maybe, because he was never heard of again!

It's still possible that your tinnitus could ease once you've reduced or stopped taking Prozac. And if you do need to take an AD, perhaps another type may be gentler on the ears.

You know you're flying very close to that raw sea anemone extract guy, with your seaweed theory here. Tread cautiously. You know what happened to him.

I think you're dropping your dose too much too soon as well. Please take your time weaning yourself off something like Prozac. No doubt you're aware of AD withdrawal syndromes that cause all sorts of complications, like brain zaps, restless leg syndrome as well as tinnitus as a byproduct. I'm...

I know nothing about share trading in bio stocks, but I would suggest that Frequency Therapeutics isn't just about ears, it's about a specific type of technology called progenitor cell activation. It's a bio engineering tool that can be applied to a variety of the body's organs and nerves. It...

I commend you on your ability to adapt with such relative speed to the assault on body and soul that is tinnitus. You're better than me! Changing your reaction to this condition is exactly what one must do, yet I find it so overwhelming sometimes, that I find myself wallowing endlessly in...

A healthy diet has been found to preserve hearing in older individuals. Perhaps there's a message there for younger people too! All the more reason to eat your veggies and the odd fish too! https://www.sciencedaily.com/releases/2019/11/191118190855.htm

Yes TT is a good start, but I don't think it should take any dancing fairies to get some real world evidence. Dental drilling has been going on for an awfully long time and if there was a causal link, it would be reported widely. In fact there should be an epidemic of hearing loss due to...

I agree! But the question I posed in my last post was whether or not conductive sound and vibration, as a result of dental drilling, cause permanent auditory damage. I have felt conductive sound in the dentist's chair in the past without damage to my hearing. Countless millions of dental...

Oh dear! And down the rabbit hole fell poor Alice!

Yes I understand exactly how you feel. I have similar fears to you about dental work. But I also suspect that with an understanding dentist, with the aid of hearing protection, pauses in drilling when requested, these risks can be mitigated. There is a thread about dental work and tinnitus on...

I understand your fear about drilling affecting your ears, but resorting to simply extracting a tooth without exploring all other possibilities seems extreme to me. I would have thought trying ear plugs first or if occlusion is a problem, perhaps noise cancelling earphones, as some dentists...

Why not? Once the tooth is drilled out and the source of infection and decay is removed, the tooth can then safely be rebuilt. Is that not how it works?

I'd acknowledge your respective arguments @Chriscom and @linearb, if we were still in the early stages of this research, but we're not. We're at the final gate prior to bringing this machine out into the public after nearly twenty long years. At least as a first generation device. This phase...

But did it make you feel more youthful and energetic?

That's an utterly ridiculous stipulation.

And what if there's even some vaguely related evidence for it? Good Noise, Bad Noise: White Noise Improves Hearing Note: 'The data of the research group showed that white noise significantly inhibited the activity of the nerve cells in the auditory cortex.'

Sadly, no joy for those with hearing loss outside their stated parameters. With arguably more intrusive tinnitus and greater barriers to habituation when there is less ambient sounds coming into the brain, here is a cohort with a profound need, but who remain unserviced by Lenire. Even those...

Unfortunately Dr. Shore, unlike Lenire, has been in no hurry to have her version of this therapy commercialised. She's been at this for nearly two decades after the initial tinnitus neuromodulation results came out of the University of Minnesota. And she's had successful results on humans for...

I think it's more than that. I recall my audiologist explaining some technical reasons why it's not done at present, that you'd probably be very familiar with. It explains why a company like Signia advertises hearing aids supposedly going up to 12kHz, for those wanting to appreciate music...

Sure! Technology may evolve to solve this issue one day.

It appears that within the current realm of hearing aid technology available on the market, the devices suffer from poor efficiency once they head into the ultra high frequencies. Even those designed to go beyond the regular speaking ranges. It'd be great if aids could work properly beyond...

Technically it's not possible at the moment within the dimensions of a regular hearing aid. Perhaps the electronics experts on TT could explain the physics required. I do know that even hearing aid manufacturers that boast frequency amplification up to 12kHz, such as Signia, really only manage...

A fabulous opportunity for all US citizens on Tinnitus Talk, with demonstratable hearing loss, to get themselves into the trial.

Yes! Lenire's exclusions hurt a lot. If Susan Shore's device has the same limits, then things are going to look pretty bleak for some us for a fair while longer.

I don't think this question has been covered before, but does anyone know if Susan Shore's device will have the same hearing loss limits for potential users as for Neuromod's device? Has she given any clues at all in this regard?

@JohnAdams Have you ever discussed some of these new compounds that we're all having to wait years for with Minbo Shim? As a researcher, he'd probably be allowed to access them from the manufacturers and run his own trials on willing patients. He seems quite proactive in this regard.

There is already a thread about the Hough Institute. Can all this be shifted to one thread to streamline traffic and information?

Well aspirin, you can do without. But goodness me, giving up coffee! You can tell the good doctor where he/she can stick that advice!

Welcome to the forum Mary. Sounds like you've got some hearing loss and it could be progressing. Have you had a hearing test? Find a good audiologist and see where where your hearing is at. Some people get tinnitus relief from hearing aids, but this depends on where the lost frequencies lie...

Speaking for myself, there definitely is. The greater the progression of my hearing loss the louder and more intrusive the tinnitus became. There's a cruel logic in it for me. The less sound coming in through my ears, the greater the hyperactivity in the brain and the greater the percepeption...

Frustrating that some trials can progress so quickly, whilst others just drag on and on.

I agree with you on this. Delivery of the drug into the cochlea will be the crucial issue and I wonder if Frequency's hydrogel will be enough to do the job. If the results of the FX-322 experiment on the cochlea removed from a patient were deemed successful, but not necessarily as robust as...

Yes she's certainly implying her methodology and process is superior. But the questions remain. How is her device different to Lenire's? And is it better?

Thanks for your correction. It's Michigan, not Minnesota.

There may be some truth to that. But it's an interesting comment she's made. I wonder exactly what she means. All these devices are based on the same timing experiments conducted at the University of Minnesota. I would've thought timings would need to be the same for all the devices. Unless...

Indeed she is. She's also a fully tenured academic. She gets paid whether her device goes to market or not. All I'm suggesting is that had she sought a commercial partner earlier, she wouldn't have needed to wait for funding for her trials and this machine may have been released already. She...

No one would be happier than me to see this come out by 2020. I'll be standing right behind you in the line to get into the clinic. Susan Shore has been working on this for nigh on twenty years. People on Tinnitus Talk have participated in her earlier trials with successful results, years ago...

Don't hold your breath. Susan Shore is an excellent research scientist, but sadly she's in no rush whatsoever to get her device to market.

Don't you guys in the US head down south to Mexico when wanting to access clandestine medical treatments?

This drug is an anti-inflammatory medicine and mitigates swelling in the inner ear, which is believed to cause Meniere's Disease symptoms, such as vertigo, fluctuating hearing loss and tinnitus. They also believe it can prevent inner ear damage becoming permanent due to noise, SSHL, or...

This is really exciting news for Meniere's sufferers, but also possibly for people with newly onset acute tinnitus and hearing loss. It may potentially be able to short circuit some of the damage that most of us now have to live with. Most heartening however, for future possible hearing loss...

This is going to be like watching paint dry and grass grow. I wonder if there are any Tinnitus Talk members participating in these trials.

If you have habituated to tinnitus, then you are fortunate. Some people's tinnitus is so loud, that they cannot habituate. Without the benefit of objective measurement, it is futile entering into a pissing contest over how loud one's tinnitus is. For some people, holding onto the hope that a...

Chinmoku was talking about Audion completing recruitment for Phase 2, not Frequency.

Did they suggest you apply for Phase 3 trials, if they go ahead, or is your hearing too 'good' to qualify?

They are looking for trial participants, if you're feeling game.

This may have been stated before, but I guess it helps to be mindful that Progenitor Cell Activation is a groundbreaking technology that is in its embryonic stages. Frequency Therapeutics has decided to choose hearing loss as its first target, but the technology is aimed at many different...

I would like to ask someone, when they have their appointment, to query the consultant as to why someone with disqualifying hearing loss, but who wears hearing aids, cannot still use Lenire. It doesn't seem to be a precluding factor for Susan Shore's device as far as I can tell. At least not...

It's disappointing not to have more conclusive results of success at the first attempt. We'll need Phase 2b results to get a better handle on FX-322's efficacy, but even if it fails at that point, it may still not be over. I recall reading reports of research into nano particle delivery of...

It could get awfully crowded in there. I wonder about hearing quality and how 'natural' hearing will feel, with all these hair cells propagating all over the place.