Member- Aug 28, 2019
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- Tinnitus Since
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- Cause of Tinnitus
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This thread is about the nonprofit research institution the Hough Ear Institute and its hair cell regeneration project for hearing loss and tinnitus. The HEI is led by Dr. Kopke, an ex-US army veteran of 26 years.
https://houghear.org/
'The Hough Ear Institute (HEI) is a non-profit 501c3 organization committed to restoring hearing worldwide through research, teaching, and humanitarian efforts. At HEI, we are pursuing the dream "that all who have ears will hear."'
From some emails:
1.
"Hi,
Thanks for reaching out! I appreciate all your questions.
Our hearing loss pill is through Phase I clinical trials and ready for phase II. We hope to be in clinical II trials in the next 6 months to a year. Our hope is that we can run it through phase II and II clinical trials and have the drug on the market by mid-2020's.
The hearing loss pill regenerated the nerve endings that have been damaged due to a variety of reasons. This not only helps treat people with acquired hearing loss, but our studies show that it is very effective in treating tinnitus. This lines up with the prevailing theory of the cause of tinnitus being rooted in the nerve endings and overcompensating for the lack of "stimuli", similar to phantom pain from an amputated limb but with the brain and cochlea.
Government grants are highly competitive and more research is being done with the same, sometimes, less pot of money. It's a somewhat complicated process. What it comes down to is this: patents. We either have to wait for government money to come in and then move the research forward (which means people like you and me suffer longer) or we can solicit private donations to get us through Phase II clinical trials and attract "big pharma". If we wait, the patent could run out before FDA approval. What that means, is that the treatment/cure will never make it to market. No pharmaceutical company will license it knowing that the day they do – it becomes generic and insurance companies won't pay for the name brand drug. Does that make sense?
A little over a year ago we received funding from the DOD. It was for our hearting loss injection (hair cell regeneration) study. There were 73 applicants and we were the only one's funded. To me, that speaks volumes about our research and data. NIH and other government grants are a very complicated and drawn out process. You can find more information by going to the NIH website, DOD website, etc..
I hope I answered all your questions. I too suffer from tinnitus, but nothing like you and many others do. I read a lot of the comments from people on the forums. For the most part they are very sad to me. They represent real people suffering in a real way. Many people and organizations have said to them, "I have the cure" only to find out they were selling snake oil so to speak. They have been taken advantage of and in their desperation are anxious to believe the cure is right around the corner. Not to mention all the false information about tinnitus and assumptions on how drug commercialization works.
We are scientists on a quest to discover, to heal people. Our research speaks for itself. We were featured in in Molecular Therapy in May of 2018 with a hair cell regenerated in an adult mammal. We want to help you. I'm happy to take anyone's call, email, etc. to help spread the word and to raise the funds necessary to get these drugs through the clinical approval process.
You have my contact information below. Please consider liking our Facebook page and keeping up to date there: https://www.facebook.com/houghear/
If there is anything else I can answer or do for you, don't hesitate to ask.
At your service,
JUSTIN DE MOSS, M.A., CFRE
Director of Development"
2.
"Hi,
Please feel free to share my name and use the email info@houghear.org. For those that want to have an authentic conversation – I'm happy to reply and give my personal professional email like I did with you.
We also have some other amazing research going on – in the end those that support our mission are those that support innovation to help people.
At your service,
JUSTIN DE MOSS, M.A., CFRE
Director of Development"
3.
"Hi,
The drug is extremely safe and well tolerated as evidenced by our Phase I clinical trial data.
It is difficult to compare our drugs with others because they are completely different. What I can say is our approach is very novel. It's a combination of two compounds (one of which is already FDA approved). Additional, from an efficacy point of view – I'd say our data is more robust and further along. For example, we didn't have to increase our sample size to attain statistical significance. That's huge in science. Plus, we look to have a commercial product by the mid-2020's.
At your service,
JUSTIN DE MOSS, M.A., CFRE
Director of Development"
* I have no idea how legit their research is, but I thought at least it is worth discussing.
https://houghear.org/
'The Hough Ear Institute (HEI) is a non-profit 501c3 organization committed to restoring hearing worldwide through research, teaching, and humanitarian efforts. At HEI, we are pursuing the dream "that all who have ears will hear."'
From some emails:
1.
"Hi,
Thanks for reaching out! I appreciate all your questions.
Our hearing loss pill is through Phase I clinical trials and ready for phase II. We hope to be in clinical II trials in the next 6 months to a year. Our hope is that we can run it through phase II and II clinical trials and have the drug on the market by mid-2020's.
The hearing loss pill regenerated the nerve endings that have been damaged due to a variety of reasons. This not only helps treat people with acquired hearing loss, but our studies show that it is very effective in treating tinnitus. This lines up with the prevailing theory of the cause of tinnitus being rooted in the nerve endings and overcompensating for the lack of "stimuli", similar to phantom pain from an amputated limb but with the brain and cochlea.
Government grants are highly competitive and more research is being done with the same, sometimes, less pot of money. It's a somewhat complicated process. What it comes down to is this: patents. We either have to wait for government money to come in and then move the research forward (which means people like you and me suffer longer) or we can solicit private donations to get us through Phase II clinical trials and attract "big pharma". If we wait, the patent could run out before FDA approval. What that means, is that the treatment/cure will never make it to market. No pharmaceutical company will license it knowing that the day they do – it becomes generic and insurance companies won't pay for the name brand drug. Does that make sense?
A little over a year ago we received funding from the DOD. It was for our hearting loss injection (hair cell regeneration) study. There were 73 applicants and we were the only one's funded. To me, that speaks volumes about our research and data. NIH and other government grants are a very complicated and drawn out process. You can find more information by going to the NIH website, DOD website, etc..
I hope I answered all your questions. I too suffer from tinnitus, but nothing like you and many others do. I read a lot of the comments from people on the forums. For the most part they are very sad to me. They represent real people suffering in a real way. Many people and organizations have said to them, "I have the cure" only to find out they were selling snake oil so to speak. They have been taken advantage of and in their desperation are anxious to believe the cure is right around the corner. Not to mention all the false information about tinnitus and assumptions on how drug commercialization works.
We are scientists on a quest to discover, to heal people. Our research speaks for itself. We were featured in in Molecular Therapy in May of 2018 with a hair cell regenerated in an adult mammal. We want to help you. I'm happy to take anyone's call, email, etc. to help spread the word and to raise the funds necessary to get these drugs through the clinical approval process.
You have my contact information below. Please consider liking our Facebook page and keeping up to date there: https://www.facebook.com/houghear/
If there is anything else I can answer or do for you, don't hesitate to ask.
At your service,
JUSTIN DE MOSS, M.A., CFRE
Director of Development"
2.
"Hi,
Please feel free to share my name and use the email info@houghear.org. For those that want to have an authentic conversation – I'm happy to reply and give my personal professional email like I did with you.
We also have some other amazing research going on – in the end those that support our mission are those that support innovation to help people.
At your service,
JUSTIN DE MOSS, M.A., CFRE
Director of Development"
3.
"Hi,
The drug is extremely safe and well tolerated as evidenced by our Phase I clinical trial data.
It is difficult to compare our drugs with others because they are completely different. What I can say is our approach is very novel. It's a combination of two compounds (one of which is already FDA approved). Additional, from an efficacy point of view – I'd say our data is more robust and further along. For example, we didn't have to increase our sample size to attain statistical significance. That's huge in science. Plus, we look to have a commercial product by the mid-2020's.
At your service,
JUSTIN DE MOSS, M.A., CFRE
Director of Development"
* I have no idea how legit their research is, but I thought at least it is worth discussing.
Director
