That's great, thanks for restoring my hope in this drug Benevos!
Aw man. I hope this work, tinnitus sucks.
Just a question regarding Trobalt to which this drug is based on/similar MoA. Just how successful was Trobalt? Was there any sort of sub group of sufferers that it benefited most (like noise induced/stress induced) any limitations to length of time of tinnitus onset to how it affected it? How much by and how long did it last?
I know all this is in the Trobalt comments but I'm trying to get an idea on how good it actually was and how this may have potential to suppress the t. Cheers
From what i've read 50/50. Don't forget this drug is like 10 till 15 times more potent in hitting the targets compared with Trobalt what i've heard. But it's only a phase 1 trial. Despite we've got many of them, no one did really a great thing. It's better then nothing. From every trial they learn something, so we will be closer. Maybe this drug is great for some with Tinnitus with lessen side effects, i pray for them.
I can't tell u anything about noise induced/stress induced. The theory i believe the most is from Josef Rauschecker, so it's a combination of both. If they can resolve Tinnitus with hair cell regeneration? I don't know, but it looks promising. Some good researchers also believe that regeneration will reverse Tinnitus. Maybe they can supress it with DBS (deep brain stimulation), but it's a long way to go. A researcher from our country (dr. De Ridder) tried with some DBS on a few patients, some others did too. The results where 50/50 for complete supressing, but not long term.What i've read they just used wrong stimulation, to much a rectangle impuls, electric impulses from the body are more fluently so our brain habituated to the strange impulses he said. There are some papers on the web which i read (in Dutch). From the theory of Rauschecker he also stimulated the wrong area's.
The theory of Rauschecker is the only one which can explain the differences (sounds, volume, intermittent, etc.) to me. I really believe there are lots of triggers to get Tinnitus, but i believe even more there is 1 solutions to supress the symptom (tinnitus). I think lots of people would be helped if they would be able to supress the symptom. The Pharma can make big money with a Drug to supress tinnitus. There are a lot of supress drugs on the market, even more then real solutions. I don't know why, but it's logic to me. Because of much different triggers i believe it's even better to focus onsupress the symptom instead of cure the cause, a lot more people would be helped i quess. The more i read the more i believe it's a brain thing.
Still praying for this drug to work. There are a LOT of other things going on. I hope in 10 years ENT's can say Tinnitus? Give it 4 weeks, doesn't it lessen get this drugs for a few days. Also hearing loss? If it affects your life a lot u should think about regeneration. Maybe the regeneration is a double edged sword and can cure both, we don't know thill they tried. It's a long wait, but i really believe it's worth waiting for. Look where we are now. I am 9 weeks into this. Did read a lot, especially research. If u are a stranger to this, it make me laugh a bit when you read threats from 2014. There were a lot of people and researchers who didn't believe there would be clinical trials till 2025. 3 Years further, look where we are now. Already a company in trial, lot's of other lining up.
It's a promising time right now. A lot of drugs where discoverd by accident, like viagra. Well dr., it didn't lessen my blood pressure but.... The same thing happened already with DBS by parkinson sufferers, who also had tinnitus. The DBS also lessened the tinnitus for some. They only don't know really why. Some people got car accidents and brain surgery, tinnitus gone. They only don't know really why. It's like shooting with a canon to kill a mosquito now. I really would love to be so wrong and some researchers are right at the moment.
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