AM-101 Clinical Trial — Participants Updates and Discussion
- Thread starter NewGuy
- Start date
Member
- Jan 27, 2016
- 229
- Tinnitus Since
- 01/2016
- Cause of Tinnitus
- Noise induced
Why did you try antibiotics? I thought it was ototoxic for the ears! Strange that your doc gave you antibiotic, I think that prednisolone helped you the most. When I was on prednisolone (alas 3 weeks after the onset of my T which was far too late to save some of my precious hair cells) I woke up 3 times in silence end december, but it was alas temporary. If only I could have had the drug within the 24/48h, I'm sure it would have saved me a lot of damaged hair cell, and I'm conviced I wouldn't have developed permanent T, maybe I would have had a temporary one
They didn't prescribe it. I had some and I am pretty familiar with Penicillin so I wasn't afraid of trying ti. I was having some infection like symptoms too and also read a post by LA Engineer that listed a whole bunch of things he took that solved his T. Antibiotics was one of the things he tries. So I gave it a shot as well.
Prednisone helped me but its also impossible to say how much. And how much was also from my T improving on its own, such as the ringing subsiding to a hiss, something I read a lot of people go through. I did get complete silence my 1st day on it though, after having constant 5-6/10 T for the first week. I know that part wasn't my T on its own and definitely triggered by Prednisone, but after that I don't know much it helped.
Don't beat yourself up too much though. It may have helped, but I don't think it's a sure thing you would not develop T even if you took it within 48 hours. I took mine day 7, and compared to other reports, other people had much better luck with it way later. Some people reported silence for days or weeks even though they took it at a later time. I just got a few hours of silence day 1 and day 3, then just lower T, but definitely nothing like others reported.
Curious if the open label has ever helped anyone, seeing as how I'm pretty damn sure I got the placebo I'm praying it can provide some relief.
I'm having my open label shots this next Monday. I'll keep you updated. It's curious how even not having been a major issue for me to go through the first round, I feel really scared about this open label round.
i can relate my T changes a lot, i have days 0.2 out of ten, and then some days where its 4/10 and its hard
(sorry to hijack, i didnt took AM-101 or anything)
but my t has been getting low and then get louder.
thats why i find it harder to habituate
Dennis_De_S
Member
- Mar 23, 2016
- 9
- Tinnitus Since
- 09/2015
- Cause of Tinnitus
- damage from exposure to loud noises.
Hey everyone,
I've been lurking for quite some time on this forum & I've read all the 60 pages before making a remark.
First of all, thank u all for posting aobut your experiences.
I also have been participating in the AM-101 trials in Belgium. My T back then was actually compared to now lower in loudness. But I don't believe the increase in loudness has anything to do with the AM-101 trials. Since it spiked permanently on march 14.
At the moment I have the option to go for the ampact (round 2) injections next week monday untill wednesday.
For me this is a very hard decission, even after reading all your stories.
If I would take the second round of injections next week then my T will be allmost at the 7 month mark from onset.
Therefore the decission is even harder to go for it.
Is there anyone who can give some more info related to how exactly doing these follow up injections (with 100% sure the real drug) can have a positive effect on the levels of extra-cellular glutamate. And therefore be beneficial to avoid or maybe avoid more increase in the near future?
I've been lurking for quite some time on this forum & I've read all the 60 pages before making a remark.
First of all, thank u all for posting aobut your experiences.
I also have been participating in the AM-101 trials in Belgium. My T back then was actually compared to now lower in loudness. But I don't believe the increase in loudness has anything to do with the AM-101 trials. Since it spiked permanently on march 14.
At the moment I have the option to go for the ampact (round 2) injections next week monday untill wednesday.
For me this is a very hard decission, even after reading all your stories.
If I would take the second round of injections next week then my T will be allmost at the 7 month mark from onset.
Therefore the decission is even harder to go for it.
Is there anyone who can give some more info related to how exactly doing these follow up injections (with 100% sure the real drug) can have a positive effect on the levels of extra-cellular glutamate. And therefore be beneficial to avoid or maybe avoid more increase in the near future?
Would say go for it. Nothing to loose.
Even 7 months after on-set the drug can cause improvements.
Well, just back home after the three days receiving the open label round. It has been a real pleasure to be attended by the Dr Juan Manuel Espinosa who is a real professional, being comunicative and really nice at every moment. The whole experience has been smooth as silk and now I am experiencing the normal stiffness, deafness and muffled sensation which fades in a few days. Will post the evolution along the upcoming weeks.
Excited to hear from you what effect AM-101 will have on your inner ear.
Keep up us updated. I will keep my fingers crossed for you.
@Joe Bananas BEST OF LUCK!!! Glad to hear things went so smoothly. Positive signs. Please keep us posted.
- Jan 27, 2016
- 229
- Tinnitus Since
- 01/2016
- Cause of Tinnitus
- Noise induced
Excellent Joe. I'll be praying for you buddy. Hope it kicks your T's ass! Look forward to reading your progress.
- Jan 27, 2016
- 229
- Tinnitus Since
- 01/2016
- Cause of Tinnitus
- Noise induced
We had one member, @OddV reporting an improvement that late. Joe just had his and I believe he's around the 6 month mark so keep an eye on his posts. There doesn't seem to be anything definitive, and not too many members have reported their results that late, but really at this point, if it's relatively easy for you to have them done, and you didn't experience any bad side effects the first time around, what do you have to lose? It's a slight inconvenience for about 3 days, but you won't even have to report your progress daily during that trial.
Dennis_De_S
Member
- Mar 23, 2016
- 9
- Tinnitus Since
- 09/2015
- Cause of Tinnitus
- damage from exposure to loud noises.
Hello everyone,
For those who are still wondering about some AM-101 reviews:
I've had my first ampact (follow up with real product) injection today and everything went quite well.
*no real pain
*no discomfort
*slight T spike // nothing to loud
I will also update you guys after 1 or 2 weeks on the result.
The only thing I find extremely hard to manage is not swallowing after they've injected the gel!
Anyone got some tips on not swallowing for 30 minutes?
Also if u swallow alot, does it have a significant effect on a decrease in AM-101 reaching the middle ear?
Cheers!
For those who are still wondering about some AM-101 reviews:
I've had my first ampact (follow up with real product) injection today and everything went quite well.
*no real pain
*no discomfort
*slight T spike // nothing to loud
I will also update you guys after 1 or 2 weeks on the result.
The only thing I find extremely hard to manage is not swallowing after they've injected the gel!
Anyone got some tips on not swallowing for 30 minutes?
Also if u swallow alot, does it have a significant effect on a decrease in AM-101 reaching the middle ear?
Cheers!
@Joe Bananas
How're you doing buddy? We wanna hear some kickass T news from you like "Guys, I woke up this morning, searched for it but couldn't find it, WTF!".
May god bless you!
How're you doing buddy? We wanna hear some kickass T news from you like "Guys, I woke up this morning, searched for it but couldn't find it, WTF!".
May god bless you!
Exactly one week after my first open label shot. No improvement to report so far. I am dealing with an horrid diarrhea since last Saturday and it helps me have my mind out of my T, which is the same as before shots. Also, having eaten no food since Saturday and having been beholding this since then have kind of helped:
http://www.freerangela.com/
Hmm shit. Get well soon!
Hope and pray that AM-101 has an effect for you in the long run (within 90 days after the injections).
Hope so. Will keep you guys updated. All I want now is eating a tempura chicken + colesaw + cheddar + sriracha sandwich!!! Then I could go back quietly to my tinnitus hell.
Dennis_De_S
Member
- Mar 23, 2016
- 9
- Tinnitus Since
- 09/2015
- Cause of Tinnitus
- damage from exposure to loud noises.
Hahaha I'll keep that in mind broWatch a 30 minute horror movie on your smartphone
Keep up the faith Joe! give it some time, btw how did u manage the non swallowing policy
?how did u manage the non swallowing policy
I really don't know how you guys find that so difficult. For me it was easy and simple. As you lay on your side you just make sure you have a plastic glass with you. Everytime you feel you need to swallow just do the oposite and drop your saliva in the glass. Just be careful because there is an involuntary swallowing right after the spitting. Having that under control it should be nice and smooth.
What I don't understand is; why they ask you to don't swallow during 30" and then you can swallow... it sounds like bs to me. After 30" you can swallow and make the stash drain from your inner ear through the eustachian tubes I guess.
By the way, in this open label round I felt something I hadn't in the first double blind round. The tip of my tongue felt kind of numb and the spicy tabouli, the king prawns salad, the russian crab and the cold pasta salad I ate tasted like cardboard.
Hopefully there's nothing with your gustatory nerve (chorda tympani) which runs above your eardrum right behind the eardrum. If this nerve is damaged the sense of taste of your front tongue half can get lost. Usually an ENT uses the lower part of your eardrum for an intratympanic injection so the gustatory nerve cannot be hit by the needle.
So the sense of taste experience you are talking about is strange. The AM-101 substance itself cannot damage the chorda tympani nerve (0.87 mg/mL esketamine cannot anesthetize the nerve and even if the anesthesia fades after an hour). Maybe the needle of the AM-101 syringe has touched your chorda tympani nerve for whatever reason.
Would check into a hospital (neurology) immediately if I were you!
Everything is fine with my taste. That feeling lasted just for that dinner. Next morning I could taste the crappy breakfast at the Hospital in all its repugnant and mediocre glory. Thanks, guys!!
Dennis_De_S
Member
- Mar 23, 2016
- 9
- Tinnitus Since
- 09/2015
- Cause of Tinnitus
- damage from exposure to loud noises.
Second injection today // things went smooth
*Allmost no pain
*Slight T spike
*Bit of headache & nausea
For those who are still wondering or for those who have additional questions about the AM-101 u can allways ask me.
*Allmost no pain
*Slight T spike
*Bit of headache & nausea
For those who are still wondering or for those who have additional questions about the AM-101 u can allways ask me.
Dennis_De_S
Member
- Mar 23, 2016
- 9
- Tinnitus Since
- 09/2015
- Cause of Tinnitus
- damage from exposure to loud noises.
Cool! keep us posted,
hope you are T free, soon
That would be a dream come true my friend!
It would be nice for everyone suffering from T if they find cures that work!
& This AM-101 is for sure a step in the good direction.
Dennis_De_S
Member
- Mar 23, 2016
- 9
- Tinnitus Since
- 09/2015
- Cause of Tinnitus
- damage from exposure to loud noises.
3th injection
*Lil pain
*Moderate spikes in T loudness
*Headache
We'll see the result in 1-2 weeks Fingers crossed
*Lil pain
*Moderate spikes in T loudness
*Headache
We'll see the result in 1-2 weeks
Fingers crossed
3th injection
*Lil pain
*Moderate spikes in T loudness
*Headache
We'll see the result in 1-2 weeks
Excited. Keep us up to date buddy.
Hi guys,
This week, I have done the second round of 3 injections at hospital but this time with the AM-101. I have already done beginning of February 3 injections of either placebo or AM-101.
Side effect : I feel a little bit dizzy and tired. Also, my tinnitus increased a lot so far (going from 7 to a good 9).
I will keep you update in around one month.
Take care.
Noun
This week, I have done the second round of 3 injections at hospital but this time with the AM-101. I have already done beginning of February 3 injections of either placebo or AM-101.
Side effect : I feel a little bit dizzy and tired. Also, my tinnitus increased a lot so far (going from 7 to a good 9).
I will keep you update in around one month.
Take care.
Noun
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