Is reaonanceCEO in a pharmaseutical company?I think the memorization theory means that in later stages (no one knows when) drugs that focus on the inner ear are not gonna work. Basically your brains limbic system and the attention center are involved in chronic tinnitus. Thats why drugs like AM101 wouldn't work - because they only focus on area of the brain that is connected to the ear. Therefore different drugs should be used. Nowhere is it stated that memorization means that it is gonna stay there forever and cant be treated. You brought the depression example yourself- theres a reason why depression is not treated with injections. These are just theoreis of course, and need more data anad analysis. Could very well be that it turns out to be wrong (as they are still fighting about it).
However, Autifony Therapeutics is working on a centrally acting drug (AUT0063, look at the research forum). I think they might start testing it on chronic T already this year so could be that by 2015 we know whether this works or not.
Also, little effort has been put into researching what are spikes and why they happen. Because if they do happen in the ear then maybe AM101 could help with thatNaturally I am also hoping that it might help chronic sufferers and that it will pass the trials. Im simply saying that there is a 50-50 chance that it wont help people with chronic T and that the treatment working on us might reach the market in 10 years maybe. I have to say though that Im putting my bets on Autifony, as it is specifically designed for chronic tinnitus.
If you are interested in the subject I suggest you read this whole thread. There was a man here - ResonanceCEO - who is working a treatment for the inner ear. He had some wonderful insights about the matter
AM-101 TACTT1 Results Released
- Thread starter Hudson
- Start date
MemberHe's the CEO of a company working on a better way to deliver drugs to the middle/inner ear
Oh okay awsome! So is he pretty confident that something will work eventually for chronic t?
Read the thread dear
He basically said that the drugs that will come out in the next 5 years (ballpark) in his opinion wont take tinnitus away, but might be able to control it. Most of the drugs apart from AM101 and AUT00063 haven't reached trial phases yet.
So AM-101 trial which researches the treatment for tinnitus that has lasted 4 to 12 months lasts over a year, from 2014 january to 2015 august? What happens after that, phase 4? Did I understand that right, my english is very bad what comes to reading medical science based text... Are some people from this forum joined in this trial? It sucks that this kind of trials never come to Finland 
I would be more than happy to join in!
I would be more than happy to join in!
I have just returned from my AM-101 trial screening. The trial will consist of 3 injections. Being double blind, there is a 30% chance that I will receive a placebo. The doctor that I talked to was extremely knowledgable about the procedure and has very high hopes for the future of this drug. After I officially enroll on Monday, I will be scheduled an appointment for my first injection. As I said before, I will keep you updated through the entire process and feel free to ask me any questions.
I wish you luck (and of course that you will receive the right drug). Are they going to do the injection into one ear?
- Jul 21, 2013
- 842
- Tinnitus Since
- 01/2013
- Cause of Tinnitus
- Acoustic trauma from headphones
- May 20, 2013
- 394
- Tinnitus Since
- April 2013
- Cause of Tinnitus
- Maybe loud music. Not sure.
So AM-101 trial which researches the treatment for tinnitus that has lasted 4 to 12 months lasts over a year, from 2014 january to 2015 august? What happens after that, phase 4? Did I understand that right, my english is very bad what comes to reading medical science based text... Are some people from this forum joined in this trial? It sucks that this kind of trials never come to Finland
phase 3 is the last phase. After phase3, the medical regulation agencies will decide if they can release the drug on the market.
That sounds very good! Can't wait for that day! I really hope it will bring some relief to us chronic sufferers too
Hi Everyone,
I just recently joined this group, as I developed tinnitus (6db) and slight hearing loss in my right ear a month ago. I have been given the opportunity to participate in the AM101 study. I'm debating on whether it's a good idea or not. They said I have a 40% chance of receiving the placebo. Also, past participants, greater then 10% they said, have had an increase in their tinnitus! BUT the minecraft is a very cool video game (sorry, daughter interceded my message, such a booger). Ok, BUT those who don't get the placebo have on average a 50% reduction in their T. Also, just for participating, even if I get the placebo, they said I could later get the AM101 later this year.
So, do you think it's worth it? I mean, the tinnitus is awful, no doubt, but I don't want it to get worst!! My dad has t and said it doesn't bother him at all anymore (he's had it for 6 years) and told me that it takes 3-4 months to get use to.
Also, I feel like God is steering me to this study. I have to drive out of town to participate and I prayed to him about finding a place to stay, like a friend or family member. A couple of hours later I was talking to one of my friends, a teacher at my daughter's school, and she said she's from the town where they are doing it. What are the chances?! She said she would drive with me there and we could stay with her parents! The e-mail address of the research nurse running it is the same as our church too.
What do you all think? They want me to let them know on Monday.
Claire
I just recently joined this group, as I developed tinnitus (6db) and slight hearing loss in my right ear a month ago. I have been given the opportunity to participate in the AM101 study. I'm debating on whether it's a good idea or not. They said I have a 40% chance of receiving the placebo. Also, past participants, greater then 10% they said, have had an increase in their tinnitus! BUT the minecraft is a very cool video game (sorry, daughter interceded my message, such a booger). Ok, BUT those who don't get the placebo have on average a 50% reduction in their T. Also, just for participating, even if I get the placebo, they said I could later get the AM101 later this year.
So, do you think it's worth it? I mean, the tinnitus is awful, no doubt, but I don't want it to get worst!! My dad has t and said it doesn't bother him at all anymore (he's had it for 6 years) and told me that it takes 3-4 months to get use to.
Also, I feel like God is steering me to this study. I have to drive out of town to participate and I prayed to him about finding a place to stay, like a friend or family member. A couple of hours later I was talking to one of my friends, a teacher at my daughter's school, and she said she's from the town where they are doing it. What are the chances?! She said she would drive with me there and we could stay with her parents! The e-mail address of the research nurse running it is the same as our church too.
What do you all think? They want me to let them know on Monday.
Claire
@Claire43013 ... If it were me - I'd be all over it. First in line - just unfortunate I don't think they are running trials in australia
@Claire43013 Did they say that for 10% it made it louder permanently? I think for some it made it louder in the beginning and then more quiet in a few days.
Other than that: maybe discuss it your doctor
I think for some it made it louder in the beginning and then more quiet in a few days. Other than that: maybe discuss it your doctor
@Claire43013 Did they say that for 10% it made it louder permanently?
Other than that: maybe discuss it your doctor
That was my question, if it was permanent. When I asked the nurses they said they didn't know. They didn't run the first study so all the information they had was the same as the informed consent that I got.
- Feb 9, 2014
- 536
- Tinnitus Since
- 03/2013
- Cause of Tinnitus
- Likely stress, anxiety, an antibiotic and nsaids
It would be very difficult to determine if AM-101 is causative or correlative in making someone's T increase; it's kind of like saying the rooster crows every morning and the sun comes up, therefore, the rooster makes the sun come up. Stress and anxiety make T increase, maybe those T sufferers were stressed out during the experiment.
Are results available from the first test? That's what I'd want to see.
Really hope this goes well for you Claire!
Prayers
Maybe you could write Auris Medical (you find their e-mail on their website) and ask about it. However, I think that Am-101 was actually designed for noise-induced tinnitus. From what I understand, yours is not noise-induced so I nobody knows what its effect is going to be. I think you are on your own here with this desicion, since we are not doctors and can only make emotion-based decisions. But if I were you, I would try to get as much information out of doctors before making anything rash.
Hi Stina, thanks for the input. I looked into it and AM-101 works just as well for noise induced as well as otitis media induced T. I talked to my primary doctor today who basically said I could do the study if I wanted to but it was a personal decision. He also said he has T from scuba diving and it doesn't bother him. He said it's all subjective though to the individual.
This is one link that I found about the study.
http://oto.sagepub.com/content/149/2_suppl/P94.1.full.pdf+html
It would be very difficult to determine if AM-101 is causative or correlative in making someone's T increase; it's kind of like saying the rooster crows every morning and the sun comes up, therefore, the rooster makes the sun come up. Stress and anxiety make T increase, maybe those T sufferers were stressed out during the experiment.
Are results available from the first test? That's what I'd want to see.
Really hope this goes well for you Claire!
Prayers
Hi Mark!
Yes the results look good! I'm really hopeful, as you know, that this works too. I very much appreciate your prayers and support. On Monday I'll be talking with the doctor who is running the study and hopefully he won't rule me out for any reason. I'll let you know how that goes! Until then...onward with the weekend : )
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