AM-101 TACTT1 Results Released
- Thread starter Hudson
- Start date
Member@JohnDoe TACTIII is the name of the study for the aurismedical drug called AM101. Here is the site of the study with more infos: http://www.tinnitus-study.info/
I did quite some other therapies: steroids, HBO and TCM aka. accupuncture where the ones that helped me.
By the way I got T from a really loud and close firecracker, that gto threwn on me.
Today: still the same as yesterday, the gel is still in place and feels/sounds weird.
I did quite some other therapies: steroids, HBO and TCM aka. accupuncture where the ones that helped me.
By the way I got T from a really loud and close firecracker, that gto threwn on me.
Today: still the same as yesterday, the gel is still in place and feels/sounds weird.
@urtica: Hi. I am also from Germany and also tinnitus since 10/2013. But was not from noise, but stress. So I am very sure those are the neurons in my brain firing at those frequencies where I have normal hearing loss (normal for my age of 44). At least I was told. So would be also interested in your progress.
Alles Gute,
Martin
Alles Gute,
Martin
Hello again everyone!
I've been getting asked about my AM-101 treatment quite often recently - I guess it is related to new trials taking place soon. I thought I could write a quick follow-up then:
I participated in AM-101 medical trials in september 2012 after my tinnitus onset in july, the same year. I don't know what was the initial cause of my tinnitus, I suspected a couple of things but the most likely cause was the ototoxic antibiotic I was prescribed around that time (ciprofloxacin - that s**t should be banned worldwide, there are safer alternatives nowadays).
I quit the AM-101 trial early because my tinnitus worsened suddenly after second injection. I went to take a nap after coming home (it was 2-hours travel to the hospital where I was being treated) and after waking up I realized that my tinnitus was much louder in the ear where drug was injected. I panicked a lot and went back to hospital the next morning to get checked. The spike went back to normal volume after around 2 days. I didn't have courage to continue with a 3rd injection though.
I didn't feel (hear) an improvement until around a month after quitting the study. The improvements were very gradual, but they were in fact measurable - tinnitus loudness is measured several times throughout the study and the tests confirmed that I indeed did get better.
Question I'm often asked - do I attribute my improvement to AM-101? It wouldn't be fair if I said yes. I ignored doctor's orders and I tried several treatments at the same time so I'm afraid I cannot say which one of them actually helped... It literally was a matter of life and death to me so I really did everything I could to improve my chances.
Another question I'm asked - should you participate in AM-101? That unfortunately is a question I cannot answer. It greatly depends on how do you feel, how bad your tinnitus is. I was very, very afraid of this treatment - day of first injection was the most intense day of my life, a mixture of fear and hope. I'm not a religious person but I did some prayers, I cried a little, I listened to my favourite song for the last time. I was mentally prepared I'm going to lose my hearing. Yes, this is one of the possible side effects they warn you about. It is a very serious, invasive procedure that involves puncturing an ear drum and injecting unproven, experimental drug. I really don't want to push anybody into joining this study. It needs to be your decision and yours only.
The quality of medical care itself was great - I had numerous tests done throughout the study, I had a doctor that was available to me 24/7 on the phone who would answer any and all of my questions.
And last but not least, how is my tinnitus today? Much, much better. It is nowhere as loud as it was in july two years ago. I can really tell the difference before and after all those treatments I tried and I can say I'm fully habituated to what is "left" of my tinnitus. It isn't completely gone but I effectively forget about it throughout the day as it's easily masked by everyday sounds. It still fluctuates, usually being better in the morning (it's sometimes completely gone when I wake up only to come back later in the day) but as I said, it doesn't bother me one bit.
One permanent change to my lifestyle that I think some of you can relate with - I'm much, much more careful with loud noises and I do my best to avoid additional exposure. I carry earplugs with me all the time because you never know when they might be useful. Perhaps it's too much, but I even block my ears when there's for example an ambulance passing by close to me etc. I scrapped in-ear headphones completely. I listen to the music at lower-than-moderate volume and I take breaks often. Better be safe than sorry.
That would be it I guess, hopefully my story helps someone. I wish best of luck to everyone who decides to participate in further trials. Take care
I've been getting asked about my AM-101 treatment quite often recently - I guess it is related to new trials taking place soon. I thought I could write a quick follow-up then:
I participated in AM-101 medical trials in september 2012 after my tinnitus onset in july, the same year. I don't know what was the initial cause of my tinnitus, I suspected a couple of things but the most likely cause was the ototoxic antibiotic I was prescribed around that time (ciprofloxacin - that s**t should be banned worldwide, there are safer alternatives nowadays).
I quit the AM-101 trial early because my tinnitus worsened suddenly after second injection. I went to take a nap after coming home (it was 2-hours travel to the hospital where I was being treated) and after waking up I realized that my tinnitus was much louder in the ear where drug was injected. I panicked a lot and went back to hospital the next morning to get checked. The spike went back to normal volume after around 2 days. I didn't have courage to continue with a 3rd injection though.
I didn't feel (hear) an improvement until around a month after quitting the study. The improvements were very gradual, but they were in fact measurable - tinnitus loudness is measured several times throughout the study and the tests confirmed that I indeed did get better.
Question I'm often asked - do I attribute my improvement to AM-101? It wouldn't be fair if I said yes. I ignored doctor's orders and I tried several treatments at the same time so I'm afraid I cannot say which one of them actually helped... It literally was a matter of life and death to me so I really did everything I could to improve my chances.
Another question I'm asked - should you participate in AM-101? That unfortunately is a question I cannot answer. It greatly depends on how do you feel, how bad your tinnitus is. I was very, very afraid of this treatment - day of first injection was the most intense day of my life, a mixture of fear and hope. I'm not a religious person but I did some prayers, I cried a little, I listened to my favourite song for the last time. I was mentally prepared I'm going to lose my hearing. Yes, this is one of the possible side effects they warn you about. It is a very serious, invasive procedure that involves puncturing an ear drum and injecting unproven, experimental drug. I really don't want to push anybody into joining this study. It needs to be your decision and yours only.
The quality of medical care itself was great - I had numerous tests done throughout the study, I had a doctor that was available to me 24/7 on the phone who would answer any and all of my questions.
And last but not least, how is my tinnitus today? Much, much better. It is nowhere as loud as it was in july two years ago. I can really tell the difference before and after all those treatments I tried and I can say I'm fully habituated to what is "left" of my tinnitus. It isn't completely gone but I effectively forget about it throughout the day as it's easily masked by everyday sounds. It still fluctuates, usually being better in the morning (it's sometimes completely gone when I wake up only to come back later in the day) but as I said, it doesn't bother me one bit.
One permanent change to my lifestyle that I think some of you can relate with - I'm much, much more careful with loud noises and I do my best to avoid additional exposure. I carry earplugs with me all the time because you never know when they might be useful. Perhaps it's too much, but I even block my ears when there's for example an ambulance passing by close to me etc. I scrapped in-ear headphones completely. I listen to the music at lower-than-moderate volume and I take breaks often. Better be safe than sorry.
That would be it I guess, hopefully my story helps someone. I wish best of luck to everyone who decides to participate in further trials. Take care
Urtica also you can always drug test yourself to see if you got the drug. I think, IDK. I really have no idea what esketamine would show up as for sure.
That would not work even if your standard drug test tested for Ketamine. The amount administered is 1/1000th of a clinical dose used for anesthesia. It would most definitely fail to show up on a drug test.
I can't say for sure, but I think it can be both... Few months after the whole study ended I talked with my doctor again and I asked about results and if other patients had any problems. He couldn't get into details of course, but he mentioned that there were some cases of complications related to ear drum not closing properly. According to him, punctured ear drum of a healthy person recovers fully in 24 hours. If it doesn't happen, it can lead to infections and further problems.
Thank you so much for sharing your experience with us. I hope so much that this helps your tinnitus? Since you mention you are still having hearing changes from the injections, I was wondering how recently did you receive them?
It's been a week now since the first injection and I'm starting to get worried, because it has not imprived since then. My ear still feels numb, my T is loud as hell and my hearing is still weared, distorted... grr tomorrow I'll call the doctor and ask her if that's still normal.
Did it get louder due to the injections? Maybe it doesn't work on stress-induced tinnitus then or perhaps you've simply had it too long.
Urtica that this normal. People have complained that their T has became worse and then overnight the T dropped significantly. I do not think you should be worried to much, I think what your describing is quite normal. But yea call these people up. Good Luck.
I think I read from Reddit that it took 2 weeks for them (with much louder T) before noticing their T drop.
As long as your hearing is wierd and distorted you can not expect the T to drop. They Go hand in hand. Just relax and wait the effect of the medicin out a bit more, It will be alright. Even if only 5% of the people in phase 1 had damaged hearing and increase of T forever they wouldn`t have gone to phase 2. Too much at stake for these companies. It`s gonna be fine .
Did you read the first reddit post in this thread? That guy said the tinnitus was bad for a while before eventually, slowly fading away.
Here's the link in case you missed it
http://www.reddit.com/r/tinnitus/comments/1m1kiy/follow_up_on_am101_study_i_participated_in/
So are you saying in phase 1, about 50 healthy people injected themselves with AM101 for money ?
All the people who's had am101 that i've spoken to (4 or 5 people) said that it was a lot worse for a week or so after, and then after 2 weeks maybe it went down, and they got a lot better.
This could be due to the cut in the eardrum, but also the gel. When I had fluid (water) in my ear, T was suuuupoer loud for a week or so.
- Jul 21, 2013
- 842
- Tinnitus Since
- 01/2013
- Cause of Tinnitus
- Acoustic trauma from headphones
It came back down... thank god.
I've had a couple times where the volume got flipped to super max. No one likes that!
Wow! Thank you guys for the quick response, you are a really supportive community here!! You really helped me to cheer up! I didn't reach the doctor today. But it seemd to get slightly better than yesterday. My ear feels less cloged and the T is slightly quieter. I hope its getting better now over the days. I'll keep you updated, I have a doctors appointment on friday.
Are there any clinical trial options for someone with recent onset in the Northeast US at the moment?
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