Yeah seems like they definally are goin in the right direction. Getting even more complicated, i wonder what would happen if you combined am10 and autifony together at once!
Autifony Therapeutics Phase I Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus
- Thread starter Hudson
- Start date
MemberI don't think that we can expect these treatments to be cumulative. As I said above, it is my belief that these are separate drugs (with drastically different delivery methods) and target different sub groups of tinnitus patients.
Oh okay got it!
Who knows though? Maintain guarded optimism, and I may be proven quite wrong. I'm just a guy on a forum on the internet after all, not an expert.
Your a smart guy on a forum on the internet!Who knows though? Maintain guarded optimism, and I may be proven quite wrong. I'm just a guy on a forum on the internet after all, not an expert.
I know that autofony says that unlike other drugs that are aiming to regenerate hair cells naturally, that there aiming to boost the hearing that we have left instead, being able to understand speech more properly. For hearing loss thats great, and even people that have hearing loss and tinnitus together which boosting there current hearing could inprove the T. But i hope that those who have good hearing with loud T that would help also.. Im sure this has been discussed before but thats my only worry that there aiming mostly for hearing loss, and "possibly" that will improve/cure T too. I guess since the rats T seemed to go away that they think it could help but what if the rats hearing just improved some and still had T...
The stuff autofony messes with to stop T.. I hope they know what they're doing? What if the T lowers but u get bad H?
bill 112
Member
Wouldnt imagine so,if that was the case the healthy participants in stage 1 would have developed H or T after the drug was administered but they didnt report any difficulties or problems with hearing after the trial so why should it be any different for us.
This is just from my reading of the site and posts here, but from my understanding, the benefits to hearing and tinnitus both come from causing the specific sodium gated potassium channels that are being targeted to cease hyperactive firing and self-regulate. So it's like if all the lights in an intersection got stuck on green -- the tinnitus is all the cars that aren't supposed to be getting through and are and the hearing loss is all the cars that are supposed to be getting through and aren't.
Part of this is pure optimism, but though there are multiple channels that could be targeted, it does sound like Autifony is aiming at the right one. It's a finite list and they quite definitely set out to regulate a specific channel, one that has not been deliberately acted on pharmaceuticaly before.
bill 112
Member
Yes indeed Grace,the idea is to help improve hearing through this drug but I dont believe it is by boosting the auditory system,its purpose is to regulate voltage gated potassium channels back to a pre T state function and to help these channels function normally and not irratically as they seem to do in T and H patients.In their literature they state for hearing loss that alot of people present with perfect audiograms have difficulty with speech interpretation and hearing in noisy environments,they believe it is these channels not functioning properly thats the cause of their hearing loss and by regulateing these chanels they believe this can be greatly improved.
Evolution-wise, I 'd think rats have the same need for good hearing as humans. This makes me think their audiotory system is as complex as ours.
If they are able to cure T in rats, why should that be easier than in humans?
I think we're close to something
If they are able to cure T in rats, why should that be easier than in humans?
I think we're close to something
bill 112
Member
Very true and we have to recognise that modern medicine is becoming more and more advanced,they no longer develop medicines to target a whole area which makes it less affective and leaves the individual with nasty side effects,modern medicine is becoming so advanced that they can actually target specific cells and channels thus greatly improving effectiveness and minimizing side effects.I recently read in the newspaper about a new anti depressant that is targeted at specific cells and channels that it will revolutionise treatment for people suffering from depression and is said to be completely side affect free.And of course with the new cancer treatment currently going through trials they were able to develop a drug that told the tumour and cancerous cells to not fight against the immune system.If somebody asked me to develop a drug that could do this I honestly wouldnt know where to begin,but yet the patients survival rate without treatment was 20-30% and thanks to this treatment the overall survival rate was an amazing 98%.
I know it's been a long time since my last post, but I feel the need to chime in on this one. I am able to find solace in the fact that leading researchers are coming to the consensus that potassium channels may be a CRUCIAL piece of the puzzle. When the top researchers in the world are able to agree on something, one can assume that some real progress is being made. Until then, we have a great deal of resources that can help us cope in the meantime. If the pace keeps up, a treatment will be here before we know it. Stay strong!
yes, if potassium channel consensus is correct, and so much suggests it is, a drug that hits the spot WILL deliver.
The science looks good on its own, even without the participation of those adorable rats!
Although tinnitus research receives little funding, it does perhaps benefit indirectly from funded research in other related brain fields (parkinsons, schizophrenia, depression, etc), so we shouldn't be too surprised.
I hope everyone here finds peace. (soon)
- Aug 14, 2013
- 2,455
- Tinnitus Since
- Resolved since 2016
- Cause of Tinnitus
- Unknown (medication, head injury)
You should become a scientific journalist; one who explains science in layman's terms.
After reading your post, even I can understand the mechanism now...
hey dan,
I googled retigabine and it seems like it is thought that it can prevent tinnitus from forming- any idea why they think autifony might work on individuals who already have tinnitus? ie-- is there something in the mechanism of retigabine that is different from autifony?
I googled retigabine and it seems like it is thought that it can prevent tinnitus from forming- any idea why they think autifony might work on individuals who already have tinnitus? ie-- is there something in the mechanism of retigabine that is different from autifony?
Johno
Member
- Jan 8, 2014
- 231
- Tinnitus Since
- 6/07/2012
- Cause of Tinnitus
- acoustic trauma
Sometimes i think, all of those companies will only abuse our suffering and earn a lot of money. But okay, i am in depression mood today 
i read that retigabine is a kv7 modulator-- where autifony is a kv3 modulator-- any idea why a kv3 modulator might work on tinnitus that already exists where kv7 modulator (retigabine) has only been shown to work to prevent tinnitus- does anyone know if they have tried testing retigabine on already existant tinnitus?
bill 112
Member
Interesting read Tom and I have more faith now than ever for Autifony and am looking forward to stage 2 trials.My T and
Im not too sure but kv3 modulators like autifonys aut00063 is more targeted for auditory circuits and pathways in the brain where kv7 modulators are targeted at other pathways more concerned with calming electrical activity concerned with epilepsy.Its possible it could be of use to you and I have read a few posts on other forums where people claimed it greatly reduced or cured their T and H completely but I cannot speak for certain of these stories authenticity.There was even one woman who was prescribed medication for tremors by her neurologist and it cured her T and H but if its authentic I do not know but it is encourageing.
bill 112
Member
Sure Matt no problem,google search anti convulsants for hyperacusis and a story on the hyperacusis forum should appear where a woman calls them a miracle drug for her H and T,also on the hyperacusis forum there is a thread called H and T cured and this is about the woman with the tremors,also if you search through google there are other forums where one woman is writing on her husbands behalf who was prescribed anti convulsants and that his T was greatly reduced by it,there is also another story of a woman who took an anti convulsant and her T disappeared for two years.Sorry I didnt post links cause this computer wont allow me to but these stories are very fascinateing.Reply when youve found them and tell me what you think.Cheers.
Sorry for bumping if this has already been answered, but when do we get the next batch of news on this? Is a trial going on now? When will we get solid efficiency numbers?
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