Autifony Therapeutics Phase I Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

#61
I realize that the results of Phase I trials will be out in spring 2014. Would trials from Phase II-Phase IV take the same time (eg. around 1,5 years for one) or would it be more?
 
#63
I also read that this has potential to help presbycusis (age related hearing loss) and I will be interested to see how well it works. The company could make a lot of money with aging baby boomers.
 
#64
Yeah the brain memorization thing is bullshit.

Tinnitus is a perception, not an infection. It doesn't change your brain, but the reaction to it does. We're all just anxious about the noise and our brain reacts. Doesn't mean the brain somehow "stores" the tinnitus in memory... that is just retarded sounding.
 
#66
sgal said:
Hi Robb,
What are you referring to? Thanks.
Click to expand...

I don t belief T wont go away because it is memorised.
If this was the case there would not exist in such a high variance a fluctuating T or when coming out of a shower almost complete silence (would be weird).

So I refer to my own opinion that with the right development T can be fully cured.
 
#67
Robb said:
I don t belief T wont go away because it is memorised.
If this was the case there would not exist in such a high variance a fluctuating T or when coming out of a shower almost complete silence (would be weird).

So I refer to my own opinion that with the right development T can be fully cured.
Click to expand...

Im curious, has a doctor actually ever said that the brain memorizes it so that it will stay there forever or perhaps some patients just got it wrong?
 
#69
I've never heard of this idea before that the brain memorizes the tinnitus and was wondering where did the idea come from? I mean is there a link to an article or something scientific? I've read through the thread but don't see where it was first brought up so I have no context for it. On the face of it, from what I'm gleaning from the last few posts, it sounds like some people think that once the brain hears tinnitus, it gets stored in memory and even if the original cause of the tinnitus was cured, the brain would still hear the memory. That doesn't make sense to me as someone whose tinnitus just made a big change in its sound nature. If this theory were correct, why wouldn't I hear what I use to hear?
 
#70
sgal said:
I've never heard of this idea before that the brain memorizes the tinnitus and was wondering where did the idea come from? I mean is there a link to an article or something scientific? I've read through the thread but don't see where it was first brought up so I have no context for it. On the face of it, from what I'm gleaning from the last few posts, it sounds like some people think that once the brain hears tinnitus, it gets stored in memory and even if the original cause of the tinnitus was cured, the brain would still hear the memory. That doesn't make sense to me as someone whose tinnitus just made a big change in its sound nature. If this theory were correct, why wouldn't I hear what I use to hear?
Click to expand...
Exactly! If ones T is able to progressivly get louder and louder over time..or change sounds Then it should be able to get quieter and quieter and even cured just like before someone had T.. They just havent figured it out yet.. But someone will :)
 
#71
I read the theory of memorisation numerous times on this forum, as it was written down by some members.
Any scientific paper was not around.

So take it with a grain of salt ;)
(at least reading the memorisation stuff i memorised it and found it scary :))
 
#73
lol at my typo. I meant spike.

I'm confused about this drug though. Is this drug something you take forever? Or is this potentially something like, take for 3 months and your tinnitus will be gone?
 
#74
the whole brain memorization thing just means that the brain has a part that is continuously distorted because a cause that has passed long ago ... so if the neurons still fire away without any cause it seems to have memorized this action. nothing to worry about when they find a cure.
 
#75
nills said:
the whole brain memorization thing just means that the brain has a part that is continuously distorted because a cause that has passed long ago ... so if the neurons still fire away without any cause it seems to have memorized this action. nothing to worry about when they find a cure.
Click to expand...
If that's the interpretation then it's fine. There's plenty of stories of people losing their tinnitus after having it for years. When I hear the word "memorize" I assume that some neurons that are part of your memory will somehow "store" the signal for the tinnitus and continuously fire it back in. That makes... no sense based on my understanding of the mind, which admittedly isn't professional, but at least somewhat baseline.

So yeah, I agree - if you lose that cycle or neuronal firing or have a drug to break it or have some other therapy to fix it, it'll just go away.
 
#78
Vkis said:
Show one/
it is always - my ANT, neurigist, etc said he knows a man who
noone saw these people directly
Click to expand...

You can choose to believe people's personal anecdotes or not. There's been enough that it's believable to me.

I can't prove to you I have tinnitus. I can't prove to you my friend doesn't have tinnitus.
 
#79
Whether or Not t is remembered by the brain doesn't really matter. What matters is how we react to it. If you continually act negatively to it it will cause you distress and anxiety. This is what reinforces it. I have a friend who recently told me he has had severe t for 14 years, now he said if it was gone he would miss it! He said it has become a part of him that is like an old friend. I think this is where we need to get to. If we can achieve that then t has no power over us whatsoever.
 
#80
Linds said:
Whether or Not t is remembered by the brain doesn't really matter. What matters is how we react to it. If you continually act negatively to it it will cause you distress and anxiety. This is what reinforces it. I have a friend who recently told me he has had severe t for 14 years, now he said if it was gone he would miss it! He said it has become a part of him that is like an old friend. I think this is where we need to get to. If we can achieve that then t has no power over us whatsoever.
Click to expand...

I understand what you are saying and habituation is a really good alternative. It's just a matter of the best way to get there and what is the best method to do it. I have had T for 1 1/2 years and it seem to get worse after I got temporary conductive hearing loss from fluid in the ears during a flight.
 
#81
Habituation is amazing when capable and is done with.. But thats not the only option..theres gotta be a way around the brain mezmorization.. Its bull shit and then bang cure is found!
 
#83
Hi All - response from the CSO.

"Thank you for your email and your interest in Autifony's hearing programme. We are currently completing phase I trials with our lead compound, and hope to initiate Phase II trials later this year. Please feel free to check back with our website (www.autifony.com) from time to time for updates.
We are working hard to develop a treatment for tinnitus.

Best regards
Charles Large

Chief Scientific Officer
Autifony Therapeutics Limited"

So phase 2 trials later this year! Will be keeping my eyes peeled for this.

Mission
 
#84
James White said:
I guess some people on this forum wish they were rats :cool:

Looks promising anyway !
Click to expand...
dan said:
More Autifony talk:
Pharmatching.com

What do age-related hearing loss and schizophrenia have in common? Not much, on the face of it. However there is growing evidence that the two disorders may have a link through the dysfunction of certain ion channels in the central nervous system. Ion channels are membrane proteins that help convert chemical or mechanical messages into electrical signals in the cell.
Autifony Therapeutics Ltd, a spin-out of GlaxoSmithKline Plc, is actively exploiting this research space. Specifically, it is looking to develop new small molecule compounds that modulate the Kv3 potassium channel in the brain and thereby treat patients who either have an age-related hearing loss and tinnitus, or schizophrenia.
On 1 July, Autifony and researchers at the University of Manchester and Newcastle University received a £1.9 million grant from the UK Technology Strategy Board to develop a Kv3 potassium channel modulator for schizophrenia. The collaboration has total funding of £2.75 million. It will enable researches to select a compound from a group of potential candidates and take the molecule through preclinical development to a first clinical trial.
This comes just a month after Autifony started a Phase 1 study in healthy volunteers of another compound that targets the same ion channel – but for the age-related hearing loss and tinnitus indications.
In an interview, Charles Large, Autifony's chief scientific officer, said that it "may sound a little curious" that hearing loss and schizophrenia could be related. But the ion channels that the company is targeting in its hearing loss programme are closely implicated in brain circuits that are believed to be dysfunctional in schizophrenia.
Schizophrenia was, in fact, one of the diseases GSK researchers were investigating at the company's neuroscience drug discovery unit in Verona, Italy when management decided to shut down the centre in 2010. At the time, Dr Large and Giuseppe Alvaro were both centre directors. In subsequent negotiations with GSK, the executives acquired several pre-candidate, voltage-gated ion channel modulators and associated patent applications.
In the year up to the founding of Autifony in 2011, they started to study the compounds in hearing – leaving the schizophrenia indication aside for the time being. "The hearing story was something that we developed almost exclusively subsequent to the closure of the neuroscience division. It was something that we felt would be an important basis for the new company," Dr Large commented.
The hearing loss and tinnitus indications have in fact been the main focus of the company since that time. "It is fairly clear if you look at the statistics that despite the very large number of people who suffer from hearing loss as they age, very few end up successfully using a hearing aid. One of the reasons for this is that hearing aids don't really address one of the key problems, which is the ability to understand speech in a noisy environment," Dr Large said.
This inability to understand speech is thought to be linked with a dysfunction of the ion channels that process sensory information in the brain. By modulating Kv3 potassium channels in the auditory brainstem, the company hopes to correct these signalling problems.
Autifony announced the start of the Phase 1 study in hearing loss on 4 June. The study is expected to complete in the first quarter of 2014 after which the company plans to bring it into patients. If the compound is successful and is marketed, it could be used in combination with a hearing aid – depending on the nature of the patient's disorder, the executive said.
Since its founding in 2011, Autifony has raised £15.75 million, which includes a £5 million investment from Pfizer Venture Investments, announced on 4 June at the time of the Phase 1 trial start. Initially, GSK took a minority stake in connection with the start-up. This stake has since been diluted and the company's three largest shareholders are now SV Life Sciences, Imperial Innovations Plc and Pfizer Venture Investments.
UCL Business Plc also has a small stake in connection with Autifony's work with University College London's Ear Institute on the hearing disorder project.
Meanwhile, the Technology Strategy Board grant will enable the company to carry out early schizophrenia work, without taking resources away from the hearing loss programme.
MedNous interviewed Charles Large on 28 June 2013.
Copyright 2013 Evernow Publishing Ltd
Click to expand...


Dan
Fascinating stuff (thanx for the post). Now I'm wondering if my T is a precursor to schizophrenia; do they have any historical data that would present such a correlation? Hope not...

Mark
 
#86
NeoM said:
lol at my typo. I meant spike.

I'm confused about this drug though. Is this drug something you take forever? Or is this potentially something like, take for 3 months and your tinnitus will be gone?
Click to expand...

Read the results in the beginning. I think they gave it to the rats for some 2 months and later it went away. But I think it might depend on the person, maybe it will come back. But I think most of us would be willing to do that...
Charles Large is so handsome :cat:
 
#88
Imidazolidinedione derivatives , This is the scientific name of the compound AUT00063. It has worked 99% cure in mice even 6 months post noise induced trauma. Here is the patent, as you can read in the link below, it would work for many other neurological ailments such as epilepsy, bipolar, schizophrenia, hearing loss, tinnitus and hyperacusis among others - depending on the specific channel being modulated....This could be a miracle drug.
http://www.google.com/patents/WO2011069951A1?cl=en

Any molecular biologists here who know more about the role of potassium channel gates in the CNS and their pathology and if this drug works, my question would be if this is something we'd have to take for the rest of our lives...? Will the drug lose potency over time? etc.
 
#89
dan said:
Imidazolidinedione derivatives , This is the scientific name of the compound AUT00063. It has worked 99% cure in mice even 6 months post noise induced trauma. Here is the patent, as you can read in the link below, it would work for many other neurological ailments such as epilepsy, bipolar, schizophrenia, hearing loss, tinnitus and hyperacusis among others - depending on the specific channel being modulated....This could be a miracle drug.
http://www.google.com/patents/WO2011069951A1?cl=en

Any molecular biologists here who know more about the role of potassium channel gates in the CNS and their pathology and if this drug works, my question would be if this is something we'd have to take for the rest of our lives...? Will the drug lose potency over time? etc.
Click to expand...


This is just an educated guess, but I would imagine you would have to take the drug for life.
 

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