Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

[RichL]

I'm sorry but this is going to take some time, I think @attheedgeofscience will know exactly where this information about there research would be located.

But for sure you have only got to look at the trial period for this drug, it will be a 4 week course of 4 pills once daily with food.....http://www.autifony.com/autifony-tinnitus-quiet-study.asp.

Unfortunately that's all I can offer you at this point in time till I can find where I read about their research.

 

[valeri]

I don't care if it's one pill or a lifetime of pills, I just want my old life back!
So whatever it takes

 

[RichL]

Here's a link to the science behind Autifony, I can't seem to find the article that mentions the follow up tests of T.

http://www.autifony.com/autifony-science-publications.asp

I'm sure someone else here will have a link to it!

 

[attheedgeofscience]

who are behind autifony ?

Autifony was founded in 2011, as a spinout from GSK. It attracted a £10 million Series A funding round from SV Life Sciences and Imperial Innovations, which both invested £5 million in the company. GSK is a founder shareholder in the company. A second close of the Series A round in 2013 led to Pfizer Ventures and the International Biotechnology Trust becoming shareholders and brought the total raised to £15.75m.

This might help.

 

[preslys]

attheedgeofscience

I think with these two giants Pfizer number 2 and GlaxoSmithKline number 3
Tinnitus has no chance to survive.

 

[Afeef]

@preslys
Hi!

What do these pictures above mean ?

 

[preslys]

@preslys
Hi!

What do these pictures above mean ?

List of big pharmaceutical companies in the world

 

[Afeef]

Oh!
I got it brother @preslys
Hope they can get T vanish for ever soon!

 

[attheedgeofscience]

I'm sorry but this is going to take some time, I think @attheedgeofscience will know exactly where this information about there research would be located.

Here is as much as I know:

https://www.tinnitustalk.com/thread...ing-loss-and-tinnitus.6516/page-16#post-73170

 

[Viktor Salvatore]

I hope soon they find something to reduce the T if not remove it all the way. Life is one day at a time for me and i pain through it. The noise does not let up. The sound sensitivity is always there. I would love to still taste my old life before i get too old and die.

 

[Mark662]

@Viktor Salvatore we all feel the same way. Fingers crossed something positive will come out from all the recent activities into finding a cure or at the least, a treatment, very soon

 

[RichL]

Here is as much as I know:

https://www.tinnitustalk.com/threads...ing-loss-and-tinnitus.6516/page-16#post-73170

Sorry, I thought if anyone else knew it would be you.

I am quite positive that I read a web page outlining their research and it was mentioned, as part of the research, that a follow up test was done and the mice or rats were still Tinnitus free 6 months after the initial dosing!

The research would have been a bit half arsed if they hadn't re tested after a certain time?

 

[Viktor Salvatore]

Thank you guys and gals for your support.

 

[PhilB]

I attended my screening interview for the Autifony Trial this morning. I had expected that I might be ruled out for either of two reasons: 1) Insufficient Hearing Loss. 2) Recent use of anti-depressants. In fact, neither of those two things seemed to concern the trial doctor very much. They performed a blood pressure test and they found that my blood pressure was quite high. They discussed amongst themselves whether I should be excluded due to high blood pressure but (luckily) they reached the conclusion that high blood pressure was not sufficient grounds for exclusion. They performed a reasonably thorough examination of my general health. Surprisingly, my hearing was just about the only thing that they did not test. Eventually, they told me that I have been accepted on to the trial but this is conditional upon the results of various tests which were performed during the examination (blood and urine analysis etc). They basically want to be sure that I do not have any other health problems which may affect my ability to participate in the trial.

I was given the impression that the requirement for hearing loss is not so inflexible as we had assumed. Too much hearing loss would make someone ineligible to participate but it does not seem that too little hearing loss would be a basis for exclusion. Also use of anti-depressants would not automatically make someone ineligible to participate. It would be at the discretion of the doctor in charge of the trial. I stopped taking Prozac just before Christmas but the doctor implied that even if I was still taking it, I would not necessarily have been excluded because of that.

Finally, I asked about confidentiality. Specifically, I asked whether I would be permitted to discuss the effects of the trial drug on this forum. I was told that it will be OK to discuss the effects of the drug on here but obviously I will not know whether I am being given the actual drug or the placebo. Perhaps we should start an AUT00063 User Experiences thread on the Treatments section of the forum. What do the moderators think?

 

[tomm]

I attended my screening interview for the Autifony Trial this morning. I had expected that I might be ruled out for either of two reasons: 1) Insufficient Hearing Loss. 2) Recent use of anti-depressants. In fact, neither of those two things seemed to concern the trial doctor very much. They performed a blood pressure test and they found that my blood pressure was quite high. They discussed amongst themselves whether I should be excluded due to high blood pressure but (luckily) they reached the conclusion that high blood pressure was not sufficient grounds for exclusion. They performed a reasonably thorough examination of my general health. Surprisingly, my hearing was just about the only thing that they did not test. Eventually, they told me that I have been accepted on to the trial but this is conditional upon the results of various tests which were performed during the examination (blood and urine analysis etc). They basically want to be sure that I do not have any other health problems which may affect my ability to participate in the trial.

I was given the impression that the requirement for hearing loss is not so inflexible as we had assumed. Too much hearing loss would make someone ineligible to participate but it does not seem that too little hearing loss would be a basis for exclusion. Also use of anti-depressants would not automatically make someone ineligible to participate. It would be at the discretion of the doctor in charge of the trial. I stopped taking Prozac just before Christmas but the doctor implied that even if I was still taking it, I would not necessarily have been excluded because of that.

Finally, I asked about confidentiality. Specifically, I asked whether I would be permitted to discuss the effects of the trial drug on this forum. I was told that it will be OK to discuss the effects of the drug on here but obviously I will not know whether I am being given the actual drug or the placebo. Perhaps we should start an AUT00063 User Experiences thread on the Treatments section of the forum. What do the moderators think?

Well that's very interesting. Do you have any hearing loss at all? Maybe a recent audiogram?

 

[PhilB]

@tomm - I 've had my hearing tested a couple of times within the last year and I have been told that it is within the boundaries of what is considered normal for my age (I am 50). There is some mild hearing loss at the higher frequencies (particularly in the right ear) but no significant hearing loss in the mid-range frequencies.

 

[RoadToSilence]

@PhilB - Congrats - that's awesome! Thanks for the update. I'm so happy that we now have a few TT members who have been accepted to the trial. Praying that you, @Shaun, and @2131e (if she is accepted) are lucky enough to get the real drug and that you will experience relief.

Anyway, this is very exciting news and hopefully it is just the beginning.

If everything goes well, 2015 could be the year that someone on this very thread finally writes the words we all want to hear, "It works...the noise is gone!" And if not gone, then at least significantly reduced.

 

[NetroPhil]

@PhilB If everything goes well, 2015 could be the year that someone on this very thread finally writes the words we all want to hear, "It works...the noise is gone!" And if not gone, then at least significantly reduced.

I certainly hope so - as do all of us here.

I wonder how long it will take to get some results off this.....

 

[PhilB]

I'm so happy that we now have a few TT members who have been accepted to the trial. Praying that you, @Shaun, and @2131e (if she is accepted) are lucky enough to get the real drug and that you will experience relief.

Thanks @RoadToSilence - Incidentally, I also asked at what point the participants will find out if they have been given the real drug or the placebo. And I asked what would happen in the event of the drug showing impressive results for those who are given the real drug. Would the placebo group be offered the chance to try the real drug after the trial is over? The doctor said that the results would have to be conclusive (i.e. showing strong evidence that the drug does actually work) and it would then be at the discretion of those who are administering the trial to decide whether to give out AUT00063 to the placebo group. So she was basically non-committal on that point. I guess she did not want to promise anything that she may not be able to deliver.

 

[preslys]

las night it was my best dream in my life. I took one pill of autifony drug it cured me.

 

[Katkin]

@PhilB Good luck with the trial Phil, I hope it's successful. I'm in Manchester UK too.

 

[PhilB]

Have you applied for the trial @Katkin? It looks like you are close to the 18 month limit but you might just make it if you're quick.

 

[Katkin]

@PhilB How do I go about it Phil?

 

[Katkin]

@PhilB I'm just looking at the Website now Phil.

 

[PhilB]

@Katkin - You need to ask your GP to provide you with a referral to the trial co-ordinator at Salford Royal Hospital. Contact details at http://www.autifony.com/autifony-tinnitus-study-uk-sites.asp. I'd suggest you contact the hospital by phone ASAP to register your interest in the trial but you won't be offered an appointment until the hosptial receive the referral from your GP.

 

[Katkin]

@PhilB Thanks Phil, I have just phoned the contact details given for Salford Royal. They have taken my details and a research nurse is going to ring me back this afternoon regarding the QUIET-1 study. At which hospital are you participating?

 

[PhilB]

@Katkin - Salford

 

[Gill Hayes]

Hi all, I have just rung Wrightington Hospital. They have given me another number to ring 0115 8232600 to be assessed for suitability I presume. I'll keep you posted how I get on.

 

[2131e]

Thanks @RoadToSilence - Incidentally, I also asked at what point the participants will find out if they have been given the real drug or the placebo. And I asked what would happen in the event of the drug showing impressive results for those who are given the real drug. Would the placebo group be offered the chance to try the real drug after the trial is over? The doctor said that the results would have to be conclusive (i.e. showing strong evidence that the drug does actually work) and it would then be at the discretion of those who are administering the trial to decide whether to give out AUT00063 to the placebo group. So she was basically non-committal on that point. I guess she did not want to promise anything that she may not be able to deliver.

That's interesting @PhilB - the people I spoke to said the placebo group wouldn't get anything. Maybe you spoke to someone nicer

 

[Manuel Tissm]

@PhilB, Thank's for sharing this informations.
Can you ask the doctor, if the drug showing strong evidence that does actually work, here how long will be marketed ?