MemberAny side effects or anything while on the drug? Aside from the lowered t of course!
Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus
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Any side effects or anything while on the drug? Aside from the lowered t of course!
It's ok if you want to blindly beleive Autifony is on the right track and that they know what they are doing just because.
As for myself, I'll wait for concrete data before passing judgement. My concern is about them seemingly not following their protocol for patient inclusion/exclusion. It also probably depends on the site too (altough it shouldn't?) as there are about of dozen of them.
Maybe you still dont understand my statement. The conversation just before I made my statement revolved around the inclusion criteria. My statement was geared toward my thoughts that they know what they are doing WITH THE TRIALS. I didn't say anything to the effect that they will be successful just because they have experience. I said they have experience conducting trials. Jeez
Goodness guys this thread has gone way off track.
Sometimes you've just got to agree to disagree.
The one consistent theme throughout this thread is that we're all in this together. We're all suffering with T to varying degrees - but we have all had our lives affected by this stupid condition and every single one of us want the same thing - to be rid of tinnitus. There are 'arguments' for and against Autifony and the trial and I get that. But whatever side of the fence you're on we should all be thankful that there is a company out there that is trying to help us - and people who are willing to put themselves on the line and be involved in a trial that is at best a 'leap of faith' with their own health in order to help others. All this 'in fighting' is not doing anyone any good at all. What ever we say on here, whatever views we state it is not going to change the outcome of this trial. I respect all the views of everyone on here but ultimately only time will tell if Autifony has the solution to our problem.
Sometimes you've just got to agree to disagree.
The one consistent theme throughout this thread is that we're all in this together. We're all suffering with T to varying degrees - but we have all had our lives affected by this stupid condition and every single one of us want the same thing - to be rid of tinnitus. There are 'arguments' for and against Autifony and the trial and I get that. But whatever side of the fence you're on we should all be thankful that there is a company out there that is trying to help us - and people who are willing to put themselves on the line and be involved in a trial that is at best a 'leap of faith' with their own health in order to help others. All this 'in fighting' is not doing anyone any good at all. What ever we say on here, whatever views we state it is not going to change the outcome of this trial. I respect all the views of everyone on here but ultimately only time will tell if Autifony has the solution to our problem.
Hi Bazz, that may well be an endpoint (either primary or secondary) in the Phase 111 trial - we'll just have to wait and see on that.
If efficacy is proven in the 6-18 month criteria of the current phase 11b trial, it is a possibility that they will extend it to a wider timeframe.
If efficacy is proven in the 6-18 month criteria of the current phase 11b trial, it is a possibility that they will extend it to a wider timeframe.
It's great seeing a second person reporting positive results from the trial. It's sad seeing this thread is still useless.
I have to agree with you that this thread has been drug through the mud.
Onto a positive note, from what we know so far it appears this drug may have some potential. We are only seeing the tip of the iceberg here, but in time we might find an effective treatment for lowering volume. If the drug is showing some benefit then I would assume the drug maker is just as anxious to get the drug to market as we are. That would make its shareholders happy, and it would make me very happy as well.
Agree, lost interest in this thread a while back, might be a good idea for @Markku to close it and start a new thread for informative post's only and no opinions without substance or facts!
On a brighter note, AUT00063 is looking very promising and now it's just the wait for it to be available to all!
I really don't understand why you would close the thread with the most activity by far. If you're not enjoying the thread than goto another thread.
Your post, pointing out the obvious, is just another example of posts that really don't need to be posted! (with all due respect @tshapiro )
You obviously haven't read the whole thread and some of the bull#$#t posts it contains, (sorry no other word to describe it!), If you understood my post, you would have noted that I have not visited for some time, and if you have noted my posts on this forum, I have a bit of an issue with nonsensical posts on important threads like this was suppose to be!
I suggested closing the thread and making another but if you didn't understand my original post, I ain't repeating it.
Read every post in this thread and then give me your opinion, this is another example of posts that don't need to be in here and wasted space! you didn't really have to state the obvious to me.
Hey bro, I have read the thread daily since it started. I enjoy it. There is interesting new info on occasion. And, if you think I can't 'hang' with your posts than you obviously have no idea who I am. Anyway, I'll give you the last word and then I'll go back to enjoying the thread.
Yep, You said it, and if people would stop posting rubbish that could be posted in a PM or just kept in someones head then the thread would be interesting all the time!
Huh????, Mate I really have no idea where your going with this, but if I've got the last say, I will say this, 'Stop reading something into stuff that's not there, your right I have no idea who you are because you post under a made up name so is impossible to know who you are, and I don't believe I said anything of the sort!
You reading imagined meanings in my post and seemingly not able to understand them tell's me more than enough of who you are.
You just do that and I won't be expecting a responding post from you then huh?
Enjoy and have a great day!
No. You can't really ''improve a drug''. You can modify it or make a derivative, but then it becomes a new drug entirely so more trials etc...
They probably are working on other compounds though. But since we don't have any info, it's probably not anywhere close to be ready for other trials.
My be they are going to maximize the effectiveness of this drug by altering the compounds, that's why the trial takes long time.
I hope so... I think they are on the right way, it can be done if there is enough will.
Hi guys, jut wanted to find out where they are at currently with the trials? I meet with all the necessary criteria, am local to one of the trial sites and have the number of the local research team also. But don't want to pester them unless phase II hasn't started yet.
I would be happy to provide you all with feedback if i get accepted.
I also work in the entertainment industry and as such have a considerable understanding of excessive sound levels and related impact to one's hearing.
cheers
I would be happy to provide you all with feedback if i get accepted.
I also work in the entertainment industry and as such have a considerable understanding of excessive sound levels and related impact to one's hearing.
cheers
Hi Timmy Music, the phase 11b trial is still recruiting but is due to close at the end of this year so go for it asap ! And any feedback would be much appreciated by everyone on this thread !!
Because pill is not just for t, it is for hearing loss also. (thats what they say) Why? I suppose tactic- catch all, in phase III they can easily eliminate that requirement if there was no results in improve hearing, and be focused just on t
Hearing loss can turn into Tinnitus ... they want to see if AUT can stop hearing loss turning into chronic T ... or even reversing the T itself and maybe even influencing the hearing loss.
2 goals in one aim.
From their Autifony's website:
http://www.autifonytherapeutics.com/autifony-tinnitus-quiet-study.asp
Q. If I also suffer from hearing loss, can I expect to see an improvement in my audiogram, as I know AUT00063 is being tested also for Age Related Hearing Loss in the USA
A. No, we do not expect AUT00063 to improve the pure tone audiogram as the drug does not work on mechanisms is the cochlea itself. "063" is designed to improve auditory processing in the brain, and of course to reduce the central auditory activity that gives rise to tinnitus. A decline in central auditory processing is an important aspect of age related hearing loss, and gives rise to the difficult people have understanding speech in difficult listening environments, such as in a background of noise. In preclinical models, AUT00063 has been shown to improve central auditory processing.
So it has nothing to do with the hearing organs. All our current standard audiological methods to quantify hearing is based on the general state of cochlear hair cells (pure tone thresholds, otoacoustic emissions). They will only test for speech understanding in noise which I admit I do not know how accurate such tests can be.A. No, we do not expect AUT00063 to improve the pure tone audiogram as the drug does not work on mechanisms is the cochlea itself. "063" is designed to improve auditory processing in the brain, and of course to reduce the central auditory activity that gives rise to tinnitus. A decline in central auditory processing is an important aspect of age related hearing loss, and gives rise to the difficult people have understanding speech in difficult listening environments, such as in a background of noise. In preclinical models, AUT00063 has been shown to improve central auditory processing.
I did one of those tests last week. You hear noise and than some sentences being spoken. If you lost the higher freq in hearing it will become very hard to being able to distinguish words ... I scored pretty bad on it ... I think it is quit a solid test with what they aim to find or test. You have to repeat the sentence to the doctor so it`s water proof in that sense.
I had a test like this done but it was only simple words. I scored 100% on it but I might have cheated. The list of word was quite small and there was multiple repeats. The audiologist also had an accent I think she made sure she was as clear as possible even though in everyday situations no one would speak like this.
Yes that's what i read there which leave this hearing loss criteria unexplained.
If you go to Autifony's trial info page : https://clinicaltrials.gov/ct2/show/NCT02315508
You'll find that the hearing loss requirement is no longer there. They probably realized how little sense it made.
Well, I better give them a call then as last time I wasnt accepted because of that!! God, why do they keep shifting the goalposts
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