Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

[randomuser]

The big reduction and then coming back after ending the trial was huge news (from Ms. D, TT member and Aut guinea pig). Assuming Aut is safer than Trobalt (and because it is a more focused drug we're hoping it is), it definitely has a chance to be upped in dosage and time frame in order to DESTROY chronic T. Here's to hoping!

In fact, in the phase II trials they're using the pill for only 28 days. As you say, I see no reason to extend this timeframe, people on retigabine are taking it for longer times despite its side effects. But phase II has to finish at some point and probably is not viable to have their trialees for, let's say, 4 months or more. The good news is that trialees, at least the ones that participate here, didn't mentioned any serious side effect apart from heartburn.

 

[Robb09]

Yeah I rather have heartburn then this horrendous T. Its nothing. I wouldnt wish this T on prisoners that how bad this thing is going inside our heads!

 

[RaZaH]

I would settle for flames shooting out my arse Bring it on

 

[Danny Boy]

I would settle for flames shooting out my arse Bring it on

That can be arranged...

 

[Champ]

Yeah I rather have heartburn then this horrendous T. Its nothing. I wouldnt wish this T on prisoners that how bad this thing is going inside our heads!

As someone who went to prison I find your target demographic saddening

Not everyone whose been there is a baddie! Why not use politicians

 

[Robb09]

I just won't wish it on anyone, not even my worse enemies. I feel trapped. Although it might bring cure faster but still..

 

[Carlos Galiano]

I have high hopes for aut63. It is the closest thing to relieve tinnitus. I hope everything goes well and may benefit chronic.

 

[Dave111]

But if chanals are opening wider does it than works like a ''reset''?

 

[nills]

In fact, in the phase II trials they're using the pill for only 28 days. As you say, I see no reason to extend this timeframe, people on retigabine are taking it for longer times despite its side effects. But phase II has to finish at some point and probably is not viable to have their trialees for, let's say, 4 months or more. The good news is that trialees, at least the ones that participate here, didn't mentioned any serious side effect apart from heartburn.

it is just that FDA does not require moe data ... the pharma companies only trial as much as is needed to get it out there. That is another reason why so many horrible drugs are out there and Trobalt being one of them, is now on black list.

 

[t-man]

But if chanals are opening wider does it than works like a ''reset''?

I believe that's kind of the idea. Remember the days when you could get a "stuck pixel" on your monitor and you ran a program that basically over worked your screen until that pixel finally shut off. I think it's like that.

 

[randomuser]

I have a question, for the insiders. Does anybody know if they are testing only one molecule or more than one in parallel? In the previous thread there is a pdf with the patent and it covers, literally, hundreds of compounds, derivatives from two basic backbones. It would be useful to know that.

 

[Silvio Sabo]

I have a question, for the insiders. Does anybody know if they are testing only one molecule or more than one in parallel? In the previous thread there is a pdf with the patent and it covers, literally, hundreds of compounds, derivatives from two basic backbones. It would be useful to know that.

They are testing just the one. Any other would have to be tested separatley as a whole new drug.

They patent lots of compounds for patent protection reasons. So that noone would be able to create a similat drug and compete on the market.

 

[Robb09]

Where is trobalt on blacklist? Is it blacklisted in Canada? My Dr can't find it in his book or phone app. Showing him the wikipedia this time.

 

[Danny Boy]

Where is trobalt on blacklist? Is it blacklisted in Canada? My Dr can't find it in his book or phone app. Showing him the wikipedia this time.

It's not on sale in Canada.

 

[Silvio Sabo]

It's not on sale in Canada.

Just guessing here but can it be that it's sold under a different name in Canada?

 

[Danny Boy]

Just guessing here but can it be that it's sold under a different name in Canada?

Nada. It's not sold in Canada at all. They don't sell it in Germany and some counties at all?

 

[noisebox]

Today I met somebody who has seen the Professor in Sheffield in charge of the trial there and he said the drug is going to be one you take to fix the T and not one to stay on long term.

 

[markoana]

Today I met somebody who has seen the Professor in Sheffield in charge of the trial there and he said the drug is going to be one you take to fix the T and not one to stay on long term.

Wow, it sounds like a dream drug. But if that is truth info, it is more difficult goal to achieve, than long use drug.
However, MPT and Danny Boy did it with Trobalt, so hopes for AUT63...

Did he tell anything more about it?
tnx

 

[Sailboardman]

@Robb09 Canadadrugs.com, says they sell Trobalt.

 

[Robb09]

Just guessing here but can it be that it's sold under a different name in Canada?

@Robb09 Canadadrugs.com, says they sell Trobalt.

Its called Potiga or ezogabine in North America. I can see there is some sites that sells it http://www.canadapharmacyonline.com/DrugInfo.aspx?name=Potiga6804 but I went to 2 doctors (30yrs/40yrs experience in meds) does not know of it. But gave him copy of wikipedia about it and said they dont sell it in the city. Im going to ask a 3rd Dr soon about it.

 

[Martin69]

Today I met somebody who has seen the Professor in Sheffield in charge of the trial there and he said the drug is going to be one you take to fix the T and not one to stay on long term.

"Is going to be" the same as if he would say that he has seen the drug working in the trial?

 

[amandine]

Just a thought but would taking trobalt perhaps change or damage the brain so that autifony drug wouldnt then be effectve ?

 

[preslys]

Wow, it sounds like a dream drug. But if that is truth info, it is more difficult goal to achieve, than long use drug.
However, MPT and Danny Boy did it with Trobalt, so hopes for AUT63...

Did he tell anything more about it?
tnx

Taking this drug for the rest of life or for a short time, the most important here is the relief

 

[markoana]

For a rest of life, 3 x day, 10$ for pill. I would accept that offer..

 

[preslys]

For a rest of life, 3 x day, 10$ for pill. I would accept that offer..

It will be covered by the inssurance.

 

[ali can]

we're waiting for pill I hope we get a pill in 2016
little relief is enough for me

 

[Silvio Sabo]

we're waiting for pill I hope we get a pill in 2016
little relief is enough for me

We won't get it in 2016. Probably not even 2017. I think 2018-2020 is a realistic goal for Autifony's pill to hit the market if all testing goes well.

 

[Stu]

Just a thought but would taking trobalt perhaps change or damage the brain so that autifony drug wouldnt then be effectve ?

I'm wondering this too as I have acquired some Trobalt but don't know whether I should take it for this exact reason...
Anybody?

 

[grate_biff]

@Markku Is it now safe to say that Autifony won't be answering our Q&(A)???

 

[amandine]

I'm wondering this too as I have acquired some Trobalt but don't know whether I should take it for this exact reason...
Anybody?

How will anyone know? Some will say that it is working on the same principle of Autifony plus taking it earlier may help rather than waiting for autifony. Others can say that it alters the brain and may make autifony not efficient or so efficient. Just something to ponder but I fear there is no answer to this question but one worth asking anyway......
Trobalt is a dangerous drug but one that may save a life or lives cos this ailment is a killer mentally....and has effects physically too...