Betaserc (Betahistine)

[Frédéric]

Using betahistine in the treatment of patients with Menière's disease: a meta-analysis with the current randomized-controlled evidence

Background: Betahistine is used worldwide to treat patients with Menière's disease. However, despite it being used for decades, diverging opinions on the effect of betahistine on Menière's symptomatology still exist.

Aims: The objective of this systematic review was to provide an overview and rate the certainty of the current evidence base regarding the use of betahistine to treat patients with Menière's disease.

Materials and methods: A systematic literature search was conducted in October 2019. The search strategy was subdivided into searches for existing guidelines, systematic reviews and individual randomized controlled trials (RCT) investigating the usage of betahistine as compared to placebo, in patients with Ménière's disease. The primary outcome was the frequency of vertigo attack(s) and occurrence of serious adverse events.

Results: We identified three relevant guidelines and three systematic reviews: however, neither included any relevant trials matching our inclusion criteria. An individual search for RCTs identified one trial. The results from this particular trial showed no difference in effects on symptoms following treatment with betahistine.

Conclusions and Significance: There is a need for further well-conducted placebo RCTs. Currently, there is still a lack of substantial evidence supporting betahistine as a significant and adequate treatment for patients diagnosed with Menière's disease.

Source: https://www.tandfonline.com/doi/abs/10.1080/00016489.2020.1777326

 

[Juan]

Using betahistine in the treatment of patients with Menière's disease: a meta-analysis with the current randomized-controlled evidence

Background: Betahistine is used worldwide to treat patients with Menière's disease. However, despite it being used for decades, diverging opinions on the effect of betahistine on Menière's symptomatology still exist.

Aims: The objective of this systematic review was to provide an overview and rate the certainty of the current evidence base regarding the use of betahistine to treat patients with Menière's disease.

Materials and methods: A systematic literature search was conducted in October 2019. The search strategy was subdivided into searches for existing guidelines, systematic reviews and individual randomized controlled trials (RCT) investigating the usage of betahistine as compared to placebo, in patients with Ménière's disease. The primary outcome was the frequency of vertigo attack(s) and occurrence of serious adverse events.

Results: We identified three relevant guidelines and three systematic reviews: however, neither included any relevant trials matching our inclusion criteria. An individual search for RCTs identified one trial. The results from this particular trial showed no difference in effects on symptoms following treatment with betahistine.

Conclusions and Significance: There is a need for further well-conducted placebo RCTs. Currently, there is still a lack of substantial evidence supporting betahistine as a significant and adequate treatment for patients diagnosed with Menière's disease.

Source: https://www.tandfonline.com/doi/abs/10.1080/00016489.2020.1777326

In my last visit to the ENT I asked the doctor about several medications, including Gabapentin, Lyrica, and Betaserc. In the doctor's opinion Betaserc shows more consistent results (limited results) and the other medications are more random, meaning that some people benefit, and others do not improve, or worsen. Also in terms of side effects this particular doctor seemed to favour Betaserc too. I have not been on that drug yet, though, so cannot report out of personal experience.

 

[Kriszti]

In my last visit to the ENT I asked the doctor about several medications, including Gabapentin, Lyrica, and Betaserc. In the doctor's opinion Betaserc shows more consistent results (limited results) and the other medications are more random, meaning that some people benefit, and others do not improve, or worsen. Also in terms of side effects this particular doctor seemed to favour Betaserc too. I have not been on that drug yet, though, so cannot report out of personal experience.

In my country, Betahistine is routinely prescribed for patients with tinnitus even without other Meniere's symptoms. It very rarely does anything.

I took it for 2 months (for 1,5 month alongside with Piracetam), zero results, but I did not experience side effects either. (I suspected that my horrible insomnia was due to these meds, but it didn't resolve after quitting taking them either, so it may have actually been because of the panic tinnitus onset caused for me.)

 

[Juan]

In my country, Betahistine is routinely prescribed for patients with tinnitus even without other Meniere's symptoms. It very rarely does anything.

I took it for 2 months (for 1,5 month alongside with Piracetam), zero results, but I did not experience side effects either. (I suspected that my horrible insomnia was due to these meds, but it didn't resolve after quitting taking them either, so it may have actually been because of the panic tinnitus onset caused for me.)

Hi Kriszti, are you doing better with sleep?

 

[Kriszti]

Hi Kriszti, are you doing better with sleep?

Thanks for asking.

Slightly. I still have horrible nights here and there, but overall it is a tiny bit better. I still wake up a lot, and sometimes only can sleep 2 hours a night, but it's getting better (knock on wood). Doesn't improve the tinnitus though, and my mental health could be better, I'm pretty down, but baby steps.

 

[guenguer]

In a big study it was shown that Betahistine is practically useless for tinnitus, hydrops and Meniere's disease. That's my experience too. I took it for 4 years 3x48mg per day. It did absolutely nothing, not even protect from worsening.

 

[Hottopic29]

I was thinking of trying Betahistine.

I was reading that they actually don't know how it affects the ear. Is there any new information? It seems it's not available in the USA so most people that I talk to don't know about it...

For tinnitus, betahistine is thought to work by improving blood flow to certain areas within the inner ear. However, it is not fully understand how betahistine actually interacts within the inner ear to reduce tinnitus symptoms.

→ PubMed: Betahistine for Tinnitus

 

[Nick47]

I was thinking of trying Betahistine.

I was reading that they actually don't know how it affects the ear. Is there any new information? It seems it's not available in the USA so most people that I talk to don't know about it...

Betahistine is useless for tinnitus that is not associated with Meniere's.