Breakthrough for Genetic Hearing Loss as Gene Editing Prevents Deafness in Mice

[jcloth]

https://www.theguardian.com/science...oss-as-gene-editing-prevents-deafness-in-mice

 

[IAmCalifornia]

Where do I go to sign up?

Second article:

https://www.axios.com/hearing-loss-treated-in-mice-with-gene-editing-2518729649.html

 

[Ambassador]

I don't know, as soon as I read certain genetic hearing disorders that makes those of us with damage from noise exposure out. I wonder about age related hearing loss too, is that genetic?

 

[WaqasVic]

I don't know, as soon as I read certain genetic hearing disorders that makes those of us with damage from noise exposure out. I wonder about age related hearing loss too, is that genetic?

well at least they did something

 

[TheDanishGirl]

So how does this apply to humans??

 

[IAmCalifornia]

So how does this apply to humans??

No, because it has not been tested yet. But they're on the way. Optimistically 2 - 5 years, realistically a decade or so.

 

[frohike]

So how does this apply to humans??

It's simple Sandra, in 10 years, we will have the technology to turn people into mice. At that point we will be able to fix their hearing. Then the problem is reduced to turn the mice back into people.

 

[Aaron123]

I wonder about age related hearing loss too, is that genetic?

There is evidence that there is a genetic component, but that is not what this or other papers are talking about. Any genetic component to ARHL is much more complicated than these cases of a single mutation.

So how does this apply to humans??

It doesn't at the moment. Although according to this article (https://www.xconomy.com/national/20...to-hearing-loss-drug-race-new-study-suggests/) they are already working with pigs and looking for individuals for a trial in china with a goal to start a trial within 3 years. It's a long way from a single basic science paper to human trials much less an actual treatment.

This is more evidence that potential treatment for inherited deafness is picking up steam - I think there were 3 good papers on various types of Usher Syndrome this year.

Here's the abstract to the actual paper https://www.nature.com/articles/nature25164