Cause of Tinnitus and Hyperacusis: Postviral Lesion

[Matchbox]

So I'm currently on a long course/taper of Prednisone at 60 mg and it has made me worse again. Bilateral diplacusis with every single sound being a full tone flatter than it should be. It has eliminated a substantial amount of tinnitus but this is just BAD. I am tapering off now and going low sodium, sometimes the pitch perception fluctuates to say the least.

But honestly as my profile picture says, I am killing myself if this is permanent. This is a losing battle I'm tired of.

This is just flat out weird. The tinnitus is dissipating, yet everything is a tone lower?

Are the sound distortion effects lower/worse, or actual sounds "like someone talking" are lower (always or intermittently in little distorted blasts of lower pitch when hearing a real sound)?

I know. A lot of questions. But it kind of sounds like what happens to people on Carbamazepine which blocks sodium channels and is used for typewriter tinnitus to great success yet a side-effect in like 20% of people is pitch shifting a semitone lower.

It sounds like the steroids are doing something similar. God only knows how. Maybe with lower inflammation other neurofactors can finally bind to receptors in the nerve (and they were building up because negative feedback, you still had tinnitus so the brain made more of the factors)... and you're in the midst of a re-balance or re-myelination (if there was sheath damage from inflammation that also can repair once the inflammation goes down, and you'd be receiving "new" undegraded signals).

Prednisone might have some kind of effect on neurosteroid concentration/activity.

Did you call your specialist up to let them know what's been changing?

At any rate, when people come off of Carbamazepine, their pitch perception reverse to normal. Hoping the same for you and that once the steroids are done this all fades off and you're left with something inconsequential compared to now.

 

[__nico__]

Are the sound distortion effects lower/worse, or actual sounds "like someone talking" are lower (always or intermittently in little distorted blasts of lower pitch when hearing a real sound)?

Tinnitus, hyperacusis, distortions etc were traded off for every single real sound being a tone lower. However, this has again corrected itself over the course of 24 hours, though my dysacusis (but weirdly not my tinnitus) is back.

 

[Lukee]

Tinnitus, hyperacusis, distortions etc were traded off for every single real sound being a tone lower. However, this has again corrected itself over the course of 24 hours, though my dysacusis (but weirdly not my tinnitus) is back.

Trying to follow your comment. Dysacusis is back, but not tinnitus or hyperacusis? Does the dysacusis seem less than before?

From what you are saying it seems like you are getting better, is that true?

 

[__nico__]

Trying to follow your comment. Dysacusis is back, but not tinnitus or hyperacusis? Does the dysacusis seem less than before?

From what you are saying it seems like you are getting better, is that true?

Dysacusis is still there. I literally don't care about the tinnitus at all. The hyperacusis, if it were moderate, I could survive.

The loss of music due to dysacusis is why I'm here. I would trade it for the worst tinnitus in the world and believe me I've lived with freeway volume tinnitus for years.

To have that level of tinnitus almost disappear without getting music back is the worst insult ever.

 

[Lukee]

Dysacusis is still there. I literally don't care about the tinnitus at all. The hyperacusis, if it were moderate, I could survive.

The loss of music due to dysacusis is why I'm here. I would trade it for the worst tinnitus in the world and believe me I've lived with freeway volume tinnitus for years.

To have that level of tinnitus almost disappear without getting music back is the worst insult ever.

Maybe give it time? If tinnitus can improve, maybe so can the rest.

 

[Óscar PP]

So I'm currently on a long course/taper of Prednisone at 60 mg and it has made me worse again. Bilateral diplacusis with every single sound being a full tone flatter than it should be. It has eliminated a substantial amount of tinnitus but this is just BAD. I am tapering off now and going low sodium, sometimes the pitch perception fluctuates to say the least.

But honestly as my profile picture says, I am killing myself if this is permanent. This is a losing battle I'm tired of.

Try Ketamine and Psilocybin before doing anything drastic.

 

[Matchbox]

Tinnitus, hyperacusis, distortions etc were traded off for every single real sound being a tone lower. However, this has again corrected itself over the course of 24 hours, though my dysacusis (but weirdly not my tinnitus) is back.

Sounds exactly like Carbamazepine and auditory sodium channel blockade (and depletion).

Getting enough salt? I know it seems ridiculous but it could easily cause impedance of nerve function.

For the dysacusis, it might have nothing to do with inflammation and could just be increased firing rates or bad synapsing. If Xanax helps that, I'd say more likely the former.

Which, also, means K channel modulators should help you once they come out (one is getting close).

 

[__nico__]

Sounds exactly like Carbamazepine and auditory sodium channel blockade (and depletion).

Getting enough salt? I know it seems ridiculous but it could easily cause impedance of nerve function.

For the dysacusis, it might have nothing to do with inflammation and could just be increased firing rates or bad synapsing. If Xanax helps that, I'd say more likely the former.

Which, also, means K channel modulators should help you once they come out (one is getting close).

Each time I take Prednisone the pitch shift madness starts again. Maybe you're right.

 

[Matchbox]

@__nico__, how's the battle? Did you get to be on some antivirals?

This might be a good time to add in some Ginkgo biloba or any other vasodilators while your inflammation is down.

 

[__nico__]

@__nico__, how's the battle? Did you get to be on some antivirals?

This might be a good time to add in some Ginkgo biloba or any other vasodilators while your inflammation is down.

Prednisone isn't helping anymore and neither are the various vasodilators.

 

[Matchbox]

Prednisone isn't helping anymore and neither are the various vasodilators.

Your tinnitus came back? Are you off Prednisone, or currently tapering off Prednisone? Any distortion changes? Any improvement at all?

 

[__nico__]

Your tinnitus came back? Are you off Prednisone, or currently tapering off Prednisone? Any distortion changes? Any improvement at all?

Tapering off currently, tinnitus is back, pitch perception normal, sound tolerance back to 0, distortions the same as they were pre Prednisone.

 

[Lukee]

Tapering off currently, tinnitus is back, pitch perception normal, sound tolerance back to 0, distortions the same as they were pre Prednisone.

Shit. Sorry to hear that. I think the good news is the Prednisone had some effect at least. Maybe a form of anti-inflammatory therapy could help, or even antiviral.

If I were you, I would really look into LDN at this point as it might be able to help with both.

 

[Matchbox]

So basically no better, no worse?

No new tinnitus sounds? And the existing tinnitus sounds remain all the same volume?

 

[Matchbox]

@__nico__, bump? You still kickin' man?

 

[DebInAustralia]

K channel modulators should help you once they come out (one is getting close).

Which KV modulator is close to market?

 

[Matchbox]

Which KV modulator is close to market?

Xenon's formulation.