Cerebrolysin (BDNF - GDNF - NGF - CNTF)
- Thread starter ma7555
- Start date
- Apr 30, 2018
- 2,507
- Tinnitus Since
- 02/2018
- Cause of Tinnitus
- Single 25 mg dose of (anticholinergic) drug Promethazine
That's the amount I was taking years ago before I gradually tapered off my benzodiazepine use. For perspective, 2 mg is considered a fairly high dose. Many people only take 0.5 to 1 mg daily.
I was prescribed 1 mg x 3 times a day. But 1 mg doesn't do much for my brain disorder symptoms which is what it originally was intended for. I found 2 mg to be much better for that so now I suffer through the first half of the day and take the 2 mg later on and have it last till I go to sleep.
- Apr 30, 2018
- 2,507
- Tinnitus Since
- 02/2018
- Cause of Tinnitus
- Single 25 mg dose of (anticholinergic) drug Promethazine
Hi @danielthor -- I have a history of brain concussion and Lyme Disease, both of which can cause various brain disorders. I've dealt with many over the years, and have long searched for anything that might help give me relief. I regularly used Klonopin (Clonazepam) for 3-4 years, averaging about 2 mg a day. Recently I discovered a device that helps calm my system down that is quite profound, and still almost hard to believe. I wrote about my discovery in the following post:
Tone Pacer PRO App — Has a Very Soothing Effect on My Auditory Cortex
No, I have normal hearing up to 8 kHz. I think I have some "mild" hearing loss in my bad ear above this region though when compared to my good ear when I do a home test.
Ah then that makes me think these IM or IV shots might not work for me. I have Hidden Hearing Loss so my Hearing itself is fine, just something is damaged nerve wise or something similar. Hopefully they'll get some BDNF meds using Nanoparticles or something eventually. Thanks by the way.
But please note that I got tinnitus as a side effect from a medication "Wellbutrin" and it was instant after just 1 pill. I doubt my "hidden" hearing loss is related to my tinnitus.
- Apr 30, 2018
- 2,507
- Tinnitus Since
- 02/2018
- Cause of Tinnitus
- Single 25 mg dose of (anticholinergic) drug Promethazine
Hii @ma7555 -- I got my tinnitus as a "side effect" from an anti-nausea medication "Promethazine". It showed up the next morning as a 10+++ screeching catastrophic trauma. Thankfully, four years later, it's improved considerably, but still difficult to deal with. Sorry you had a similar experience.
Just saw this. No, I haven't tried this one yet but have come close to ordering it! I may order and try soon.
MemberYou can just order it? I thought you wouold have to get it through a doctor. Where can you get it?
I found it in a few places like this. Mostly Nootropic sites.
https://cosmicnootropic.com/products/cerebrolysin
Thank you.
I might try this out for my pain hyperacusis and tinnitus. BDNF is the compound in OTO-413.
I might want to speak to a neurologist first though. It sounds like it would be good for people who have damage in the ear from noise exposure since it repairs tissue/nerves.
Need to see if I can take it while taking Nortriptyline.
There are other peptides too like BPC-157 but that one has more reported side effects. Still some people had good results with their tinnitus while others had bad.
I might try stem cells first though since they are probably safer than this. Probably more effective too imo but it's hard to say.
EDIT:
I found a source for something very similar to Cerebrolysin called P21 at Peptide Sciences.
Apparently, this is the best source. Unless you can get it from your doctor but I cannot. I actually did see a recommendation for the one you linked too though. Personally, I'm going to stick with Peptide Sciences just based on all the glowing reviews. You need to take Cerebrolysin intra muscular or IV whereas P21 can be taken subcutaneously so that's a big plus for me too.
So, P21 is meant to be similar to Cerebrolysin but just more efficacious. They explain it here.
I'm going to order some and try it out on top of a bunch of other peptides. Going to order Semax too which also enhances BDNF.
I was reading some user reports of both Cerebrolysin and P21 and heard a couple horror stories where two people had very bad cognitive effects after taking high doses of about 2 mg intranasally. They experienced massive mood lift initially but a couple days later they had a lot of adverse cognitive effects so don't do that lol. They may have recovered though but didn't come back to report.
I also read a paper that said too much BDNF is actually a bad thing but I don't know how much that would correspond to with these.
It's meant to have good cognitive effects even if it doesn't help with tinnitus.
EDIT #2:
I found a random article on hearing loss where a doctor tried to treat his hearing loss with a course of several drugs and supplements which included Cerebrolysin and Piracetam.
For how long had you taken Clonazepam before your tinnitus onset?
After stopping Clonazepam, is it wise to use supplements and BDNF medicines right away? Or should you let the body heal first and, if so, for how long?
I got some P21 recently which is meant to be very similar to Cerebrolysin. It's meant to be more potent even. I'm going to be trying it out soon but I really am not expecting anything miraculous from it. I only got a short course just to test it out. Trying Semax too along with Epithalon and Pinealon.
- Apr 30, 2018
- 2,507
- Tinnitus Since
- 02/2018
- Cause of Tinnitus
- Single 25 mg dose of (anticholinergic) drug Promethazine
I took Clonazepam daily for about 3 years around 2000-2002. I didn't get tinnitus until Feb. 4, 2018 (a day that will live in infamy for me).
Sorry, but I since I have virtually no knowledge about BDNF medicines, I can't give an informed opinion. As far as other supplements, I don't see why they wouldn't have a positive effect on tinnitus if they seem to be having a positive effect for the whole body. Like just about all supplements, it's a process of trial and error. See what works, and see what doesn't. I really like the Tone Pacer PRO I linked to in an above post.
All the Best!
In the process of getting off Clonazepam (or after), did you take some supplements to recover? As I understand it, BNDF medications are also important when recovering from benzos.
Or are there people who say you don't have to take anything, not to intervene, because you would make the process of recovering from benzos worse?
I have it in powder form so I'm going to mix it with BAC water and take it subcutaneously into my thigh.
Since you were asking about route of administration, don't ever take Cerebrolysin or P21 intranasally. People have had extremely bad side effects from doing so.
It sounds scary but it's actually very easy to do. People with diabetes do it all the time. It only hurts a little and sometimes not at all. There's videos on YouTube that show you how to do it.
- Dec 18, 2015
- 618
- 45
- Tinnitus Since
- 03/2015
- Cause of Tinnitus
- Noise induced, loud rock concert
Bumping up the thread.
I plan to do intravenous Cerebrolysin injections next month.
Did anyone have positive results with it?
I plan to do intravenous Cerebrolysin injections next month.
Did anyone have positive results with it?
I've had P21 in my fridge now for a few months but haven't tried it. It's very similar to Cerebrolysin. Not sure if I will try it. Kind of doubt it will do anything to be honest.
- Dec 18, 2015
- 618
- 45
- Tinnitus Since
- 03/2015
- Cause of Tinnitus
- Noise induced, loud rock concert
When I came up with an idea to try Cerebrolysin with my neurologist, who started her early days career in Kazakhstan, she was very optimistic. She had lots of experience with patients with neurological disorders being helped by it, especially after stroke. She will not be the one to administer it to me, hence she has no direct benefit from me trying it.
awake 44
Member
- Nov 22, 2022
- 46
- Tinnitus Since
- 02/2022
- Cause of Tinnitus
- Years of playing in heavy metal band.
If @Mentos will get even 1% improvement after this, I'm taking the shot as well. A doctor from Kazakhstan finds it legit. So I must consult it with him:
In this case, I have high expectations.
- Apr 30, 2018
- 2,507
- Tinnitus Since
- 02/2018
- Cause of Tinnitus
- Single 25 mg dose of (anticholinergic) drug Promethazine
Hi @Mentos -- I haven't been following this thread closely, but if you're looking for compounds that help with neuroprotection and treating neurological disorders, you may want to look into Methylene Blue. I've been experimenting with it recently, and so far it's feeling like a game changer for me. I'm noticing significantly improved energy, and much better brain function.
I was just watching a video about using Methylene Blue after somebody has a stroke. If you click on this link, it will take you to a listing of several scientific papers on using Methylene Blue for various brain issues, including stroke. If you only watch it for a minute, you'll be able to at least familiarize yourself somewhat with the potential Methylene Blue may have for you. I'll probably start a separate thread on it sometime.
I do know someone with tinnitus who tried Cerebrolysin and it didn't change his tinnitus but he felt like it did have some beneficial effects.
I have Semax that I'll probably try some time.
Best place to order from, in my opinion, is Peptide Sciences from the US. There's a place called UK Peptides too which are kinda ok but the first one I mentioned is the most reliable.
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