Clonazepam (Klonopin, Rivotril)

[Nick47]

Hi @ErikaS, I take it the minute I get up. I instinctively know how bad the day will be, so I decide between 0.025, 0.5, or 0.75 mg in one go. If I take it the night before, I don't get as good of an effect.

FYI: if you're really struggling, 0.5 mg just before bed, followed by the same dose upon waking, works well. Clonazepam also bioaccumulates, as I understand.

@Cmspgran, I'm thinking of following suit. My concern is that if I take it at night, I might start to feel agitated by the afternoon. Since I tend to suffer more during the day, it seems like a better option to take it then. Could @linearb chime in and explain why they decided to take it during the day?

 

[IYIiKe]

It's possible they're experiencing benefits from it in treating their anxiety or depression. At 45 mg, with a half-life of 30 hours, it builds up substantially, and its mechanism of action changes above 30 mg.

Relationship between mirtazapine dose and incidence of adrenergic side effects: An exploratory analysis - PMC

Mirtazapine is an antidepressant with US Food and Drug Administration approval for management of major depressive disorder. Low doses of mirtazapine are often used for management of insomnia, with higher doses expected to provide more noradrenergic ...

pmc.ncbi.nlm.nih.gov