Decibel Therapeutics Partnership with Regeneron

#31
Manny said:
I don't know, I think it's a smart move. The way I see it, FX Therapeutics is sort of a get-rich-quick scheme compared to Decibel. Their funding is smaller and you can see that they outsourced their current trials to the small Alamo ENT.
This is not to say that FX doesn't have an excellent idea or that it won't work (I hope and pray that it does!)
But Decibel seems to be in it for the long haul. The ear is really, really complicated. If you want to really figure things out, you need to start from the ground up, and a top-notch research space is important. Unfortunately there is still so much about the auditory system that science doesn't know. That's the way I see it.
Personally I'm glad that both types of companies exist. The more the better!!
Click to expand...
Frequency Therapeutics is not a hearing loss company. They are working on progenitor cell activation
PCA, which the cochlea is part of their project to activate dormant progeintor cells throughout the body to repair muscle tissue, skin tissue, eye tissue and hearing tissue with much more.
upload_2018-8-27_10-28-52.png
 
#32
Contrast said:
Frequency Therapeutics is not a hearing loss company. They are working on progenitor cell activation
PCA, which the cochlea is part of their project to activate dormant progeintor cells throughout the body to repair muscle tissue, skin tissue, eye tissue and hearing tissue with much more.
View attachment 21377
Click to expand...
What's your point?
 
#33
Manny said:
What's your point?
Click to expand...
unknown.png

I'm confused what you mean when you said Frequency was in it for a "quick buck"? when they are practicing a different discipline entirely that gave then an advantage to Decibel.
 
#34
Contrast said:
View attachment 21378
I'm confused what you mean when you said Frequency was in it for a "quick buck"? when they are practicing a different discipline entirely that gave then an advantage to Decibel.
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I hear what you're saying. Maybe my view of FX was incorrect.
 
#36
The more I realize about how complicated our hearing is, the more I wonder if frequency tx's fx322 is going to be able to do the trick. It's almost a 50/50 shot. No pun intended. The mice treated with a primary ingredient of fx 322 could hear again but we dont know the quality of their hearing. They could have had major hyperacusis, distorted frequency response etc. On the other hand fx322 may be a perfect fix and give us childlike hearing. I'm obviously hoping for the latter.
 
#37
Regarding culture and office spaces...
https://www.glassdoor.com/Reviews/Decibel-Therapeutics-Reviews-E2025811.htm

"Well run startup, developing medicines for hearing"
"Pros
Great culture, transparent communication, company values that are actually followed, not just written down. Rigorous focus on science. Experienced management team. People have fun together, laugh a lot, respect each other, work hard."


However, looks like they are still recruiting expert rodent cutters rather than somebody who has experience of humans... JobAd
 
#38
Johan_L said:
Regarding culture and office spaces...
https://www.glassdoor.com/Reviews/Decibel-Therapeutics-Reviews-E2025811.htm

"Well run startup, developing medicines for hearing"
"Pros
Great culture, transparent communication, company values that are actually followed, not just written down. Rigorous focus on science. Experienced management team. People have fun together, laugh a lot, respect each other, work hard."


However, looks like they are still recruiting expert rodent cutters rather than somebody who has experience of humans... JobAd
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Damn, I wish they would come off with some more info about what their technology platform is.
 
#40
Johan_L said:
With nice offices they can more easily attract and retain the best talent.

With that said, I hope they come up with a cure ASAP...
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I have to admit, those talents are living a good life. I don't think they are in a hurry to come up with any kind of cure by the so often quoted year "2020". If it happens, it happens. They are in it for the ride, not the end-goal. And there is a lesson in that for all of us.
 
#41
Flamingo1 said:
Interesting concept. So if I sit in the lobby of a super high-end hotel for a week, maybe I can come up with a world-changing idea too!!
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Make that seven weeks, and sit under a Hawaiian rain tree. You might reach cochlear enlightenment. :angelic:
 
#42
As most of you have noted, Decibel is a different kind of company, by many aspects in fact. I won't bore you by listing them all here.

But basically, I don't think it's wrong that they invest a lot of money in floor space. In fact, I think it's a requirement. They are aiming high, and they are in it for the long haul. Space is very important for any kind or endeavor. Having all the staff under one roof has its advantages too. Space is not only about housing big machines and "expensive computers". It's also important for organizing and running the business, for day to day operations and boring things like meetings.

Science is all about organizing information and turning that information into knowledge through a very slow process with insane attention to detail, using both brain power and computer power at times. It's a very hard work in fact.

Having all this space to themselves is ultimately going to benefit the company. It's one of the three basic things every business needs - space, inventory, and staff. The importance of space should not be underestimated. Decibel understands this well I think. They are aiming for best and largest space possible, most talented staff, and presumably top-of-the-line equipment.

Like any company just starting out, it's going to have its share of ups and downs. But honestly... I think Decibel is all set for a safe and fruitful journey.

Just my 7 cents...
 
#43
Decibel Therapeutics is devoted to tackle all otological issues. They want to be a world authority on regenerative biology of the ear. Let's hope 10 years from now the word "Decibel" is a household name whenever someone damages their hearing or gets tinnitus instead of visiting the local ENT that says learn to live with it.

https://decibeltx.com/our-platform/
 
#44
Johan_L said:
They have seven job ads open on glassdoor, and its not just rodent cutters :). Have you read them? Might give you a
Click to expand...
Contrast said:
Decibel Therapeutics is devoted to tackle all otological issues. They want to be a world authority on regenerative biology of the ear. Let's hope 10 years from now the word "Decibel" is a household name whenever someone damages their hearing or gets tinnitus instead of visiting the local ENT that says learn to live with it.

https://decibeltx.com/our-platform/
Click to expand...

If they figure out how to cure all ear problems that will also mean they will cure many many many other problems including spinal cord damage, maybe even regenerating amputated limbs.
 
#45
JohnAdams said:
If they figure out how to cure all ear problems that will also mean they will cure many many many other problems including spinal cord damage, maybe even regenerating amputated limbs.
Click to expand...
tbh if you can regenerate an entire audiotory nerve, you would be able to regenerate a ton of other nerves and cure a ton of shit. I dont think they are working on something that extreme.That probably won't happen until 50 years from now and I don't think Decibel will be the ones to do it, do not get your hopes up for that. If nerve regeneration was perfected paralysis would be first on the list not hearing loss.
 
#46
Contrast said:
tbh if you can regenerate an entire audiotory nerve, you would be able to regenerate a ton of other nerves and cure a ton of shit. I dont think they are working on something that extreme.That probably won't happen until 50 years from now and I don't think Decibel will be the ones to do it, do not get your hopes up for that. If nerve regeneration was perfected paralysis would be first on the list not hearing loss.
Click to expand...
true dat.
 
#49
Contrast said:
That probably won't happen until 50 years from now and I don't think Decibel will be the ones to do it, do not get your hopes up for that.
Click to expand...
Make that 5 years!

6 August, 2018
UC San Diego researchers successfully created stem cells that could have clinical applications in spinal cord injury and disorder treatments, the university announced Monday.
...
Spinal cord neural stem cells created from human pluripotent stem cells could advance to human clinical trials in three to five years after their efficacy is proven in rodent and primate studies, according to UCSD.
...
In recent years, much work has been done exploring the potential of using hPSC-derived stem cells to create new spinal cord cells needed to repair damaged or diseased spinal cords. Progress has been steady but slow and limited.

In their new paper, first author and postdoctoral scholar Kumamar and senior author Mark Tuszynski, professor of neuroscience and director of the UC San Diego Translational Neuroscience Institute, and colleagues describe creating a cell line that appears to significantly advance the cause.
Click to expand...

Source: https://timesofsandiego.com/tech/20...-victims-ucsd-creates-spinal-cord-stem-cells/

Of course, clinical trials would take time too. But still... I don't believe it will take 50 years.

29 August, 2018
Neuroscientists at UCLA, Harvard University and the Swiss Federal Institute of Technology have identified a three-pronged treatment that triggers axons - the tiny fibers that link our nerve cells and enable them to communicate - to regrow after complete spinal cord injury in rodents. Not only did the axons grow through scars, they could also transmit signals across the damaged tissue.

If researchers can produce similar results in human studies, the findings could lead to a therapy to restore axon connections in people living with spinal cord injury.
...
According to Sofroniew, many decades of research have shown that our nerve fibers need three things to grow: first, genetic programming to switch on axon growth; second, a molecular pathway for the fibers to grab and grow along; and third, a trail of protein 'bread crumbs' that entice the axons to grow in a particular direction.

All three of these conditions are active when humans develop in the womb. After birth, these processes shut down, but the genes that control the growth programs are still sleeping in our bodies. Sofroniew's goal was to reawaken these genes and then launch the entire process anew with the three-pronged approach.
Click to expand...

Source: https://www.eurekalert.org/pub_releases/2018-08/uoc--nfr082918.php

Interesting stuff... just like Frequency Tx, they also seem to be going after progenitor cells ("the growth programs are still sleeping in our bodies").
 
#50
Samir said:
Make that 5 years!

Source: https://timesofsandiego.com/tech/20...-victims-ucsd-creates-spinal-cord-stem-cells/

Of course, clinical trials would take time too. But still... I don't believe it will take 50 years.

Source: https://www.eurekalert.org/pub_releases/2018-08/uoc--nfr082918.php

Interesting stuff... just like Frequency Tx, they also seem to be going after progenitor cells ("the growth programs are still sleeping in our bodies").
Click to expand...
I hope you're right. I'm so bewildered by this horrible ugly sound in my head. I even had a remarkably low tinnitus day today and after 9 hours at work I am actually crying right now, wishing this shit would just go the fuck away. I cant believe this has happened, not just to me, but any of us. I have prayed to God to heal me, I've been researching this as much as humanly possible. I've been guinea pigging medicines on myself. I feel like there is an answer out there somewhere right now and the answer is just locked away in the shadows.

I just want my life back. I want to enjoy music again. I want to be able to sleep without some noise playing. I'm sick of waking up and the first thought that pops in my head is "oh well there's that ugly sound." My damn brain is rewiring itself and now I have dark eye floaters and I am starting to see things moving in the corner of my vision, sometimes it's a bug sometimes it's an eye floater. That thankfully can be fixed at the doctor.

The only good thing about this is that I've met plenty of good people on this website and I've now developed an incredibly enhanced empathy for other people suffering any disease. It's like the black hand of death is reaching up out of the grave and attached to me and wont let go. And it sounds like a damn dog whistle.
 
#51
God be good to us, please. I repentance of any sin. I want to be cured as well I want you all the same. I have ear pain my ear feels cool and burning and stabbbing and also tinnitus all over my head from a loud concert. Stupid me.....
Hope we can have treatment soon soon but I dont know when this going to happen...

Love yall and let's get God involved.
 
#52
1000 said:
God be good to us, please. I repentance of any sin. I want to be cured as well I want you all the same. I have ear pain my ear feels cool and burning and stabbbing and also tinnitus all over my head from a loud concert. Stupid me.....
Hope we can have treatment soon soon but I dont know when this going to happen...

Love yall and let's get God involved.
Click to expand...
Yes. Repentance. That is the main ingredient. I pray everyday for Jesus to heal us or show me the cure. This is all part of the curse of death. I am 100% sure of it.
 
#53
1000 said:
I have ear pain my ear feels cool and burning and stabbbing and also tinnitus all over my head from a loud concert. Stupid me.....
Click to expand...
I now look at people who go to clubs and concerts without hearing protection as fv¢k1ng CRAZY to subject their ears to all that loud, unnecessary noise!! And sadly, yes, that was me at one time. :( Little did I know how sensitive our ears are.
 
#54
Flamingo1 said:
I now look at people who go to clubs and concerts without hearing protection as fv¢k1ng CRAZY to subject their ears to all that loud, unnecessary noise!! And sadly, yes, that was me at one time. :( Little did I know how sensitive our ears are.
Click to expand...

I see it the same way. If people only knew there would be nobody going to concerts or clubs. I would have given everything to be able to go back 15 years and slap the crap out of the younger version of me! This is one of the more difficult things about this affliction. I have no one to blame but my self. I most likely brought this upon myself by being young, careless and very, very stupid.

I have a hard time thinking about having children. I would be in constant fear of them ending up like me and my dad who also has tinnitus. Sometimes I think of not having any. Studies have found a genetic component in tinnitus especially between father and sons so the best might be not to have any kids and just let any crappy tinnitus genes die with me.
 
#55
Silvio Sabo said:
I have a hard time thinking about having children. I would be in constant fear of them ending up like me and my dad who also has tinnitus. Sometimes I think of not having any. Studies have found a genetic component in tinnitus especially between father and sons so the best might be not to have any kids and just let any crappy tinnitus genes die with me.
Click to expand...
By the time your kids grow up, medical science will be a lot farther along and they'll probably have a cure (or something close to it!)
 
#59

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