Rinri Therapeutics

[Subjarna]

Having objective measurements is a great promise. Otonomy and Frequency Therapeutics previously relied solely on audiograms and patient subjective reports.

 

[Nick47]

Even if their treatment doesn't work out, the delivery method they found should be useful to future trials.

I know they are genuinely confident. The preclinical work spans at least a decade. They expect significant increases in audiogram readings, from severe profound to moderate. The small cohort is elderly patients with age-related hearing loss.

 

[Muggumbo]

I know they are genuinely confident. The preclinical work spans at least a decade. They expect significant increases in audiogram readings, from severe profound to moderate. The small cohort is elderly patients with age-related hearing loss.

That's absolutely great to hear. I can't wait to see its effect on tinnitus in the future.

 

[Note]

I know they are genuinely confident.

Big news!

They expect significant increases in audiogram readings, from severe profound to moderate.

Isn't auditory neuropathy hidden hearing loss that isn't detected in audiograms?

 

[Muggumbo]

Isn't auditory neuropathy hidden hearing loss that isn't detected in audiograms?

If it heals hearing loss in general, I assume that it would heal the hidden hearing loss. The audiogram is just one way to measure it, I suppose.

 

[Nick47]

→ Beyond Biotech - Can Cell Therapy Tackle Hearing Loss?

Using its OSPREY platform, UK-based Rinri Therapeutics is developing a portfolio of off-the-shelf regenerative cell therapy products to address sensorineural hearing loss, a significant global medical challenge.

The company's lead asset, Rincell-1, is designed to regenerate auditory neurons and provide a novel treatment for patients with severe-to-profound age-related hearing loss or auditory neuropathy. The company is looking to start first-in-human trials in 2025.

Today, on the podcast we have a conversation with Rinri CEO Simon Chandler about the different kinds of hearing loss, what's being done to tackle them, and Rinri's novel approach to treatments.

 

[Aussie Lea]

The company is looking to start first-in-human trials in 2025.

We can come back in 2030 for an update on the (potential) Phase 2 results Is it like 10-15 years on average between pre-clinical and market availability...

 

[Utdmad89]

We can come back in 2030 for an update on the (potential) Phase 2 results Is it like 10-15 years on average between pre-clinical and market availability...

Great! So there really is nout! Why even bother posting about Phase 1 stuff? It gets hopes up for literally nothing.

 

[Nick47]

Is it like 10-15 years on average between pre-clinical and market availability...

Yes, unless you get in a clinical trial. That's why I always encourage people to be proactive and GET IN CLINICAL TRIALS.

All too often, I hear things like 'I don't want to be a Guinea pig,' 'There is an MRI', 'It involves surgery, etc.'

Okay, then wait 10 to 15 years.

 

[Joey72]

We can come back in 2030 for an update on the (potential) Phase 2 results Is it like 10-15 years on average between pre-clinical and market availability...

Looking on the bright side, I'll be dead by then.

 

[IYIiKe]

Yes, unless you get in a clinical trial. That's why I always encourage people to be proactive and GET IN CLINICAL TRIALS.

All too often, I hear things like 'I don't want to be a Guinea pig,' 'There is an MRI', 'It involves surgery, etc.'

Okay, then wait 10 to 15 years.

I understand the spirit and intention behind this advice, and it is indeed valuable for people who are seriously contemplating ending their lives. However, for most others, it seems dangerous.

For those of us with families, especially young ones, this mindset isn't viable. Even if life is a living hell most of the time, if I can survive and provide for my family, that's just how the cookie crumbles. There is no way I can risk worsening to the point where survival is no longer possible or where I can't give my family the quality of life they deserve. I suspect many here, even in the worst of spirits, are hanging on for their loved ones.

I can't afford to spend tens to hundreds of thousands of dollars on flights and missed time from work.

For every study with even moderate efficacy, you'll find tens to hundreds of others that are akin to a slightly polished Unit 731. Some leading figures in tinnitus research, according to this forum, regularly prescribe narcotic "cocktails" that have about as much scientific backing as trying to pray tinnitus away.

It's probably best to wait for results, even if they don't come until after we're gone. Hopefully, with advances in AI and other research, these answers can come in years rather than decades.

 

[Nick47]

I understand the spirit and intention behind this advice, and it is indeed valuable for people who are seriously contemplating ending their lives. However, for most others, it seems dangerous.

For those of us with families, especially young ones, this mindset isn't viable. Even if life is a living hell most of the time, if I can survive and provide for my family, that's just how the cookie crumbles. There is no way I can risk worsening to the point where survival is no longer possible or where I can't give my family the quality of life they deserve. I suspect many here, even in the worst of spirits, are hanging on for their loved ones.

I can't afford to spend tens to hundreds of thousands of dollars on flights and missed time from work.

For every study with even moderate efficacy, you'll find tens to hundreds of others that are akin to a slightly polished Unit 731. Some leading figures in tinnitus research, according to this forum, regularly prescribe narcotic "cocktails" that have about as much scientific backing as trying to pray tinnitus away.

It's probably best to wait for results, even if they don't come until after we're gone. Hopefully, with advances in AI and other research, these answers can come in years rather than decades.

Valid points.

My main point is that @linearb has found Auricle to be effective for him, and it's just a matter of time since he was in the Phase 1 trial 7-8 years ago.

Stem cells, gene therapies, and implants are still far off. A reputable company like Rinri Therapeutics prioritizes safety and regularly monitors patients in trials.

This is slightly off-topic, but for patients considering trials, the two Extracochlear ones and Neurosoft are definitely worth looking into.

 

[tomytl]

Here's a new article about the planned clinical trial in 2025:

On the verge of reversing deafness

A revolutionary approach to treating hearing loss is emerging. Sheffield researchers are developing novel cell therapies that could repair the damaged inner ear, potentially reversing deafness for many.

www.sheffield.ac.uk

 

[Nick47]

A new article, with some information on the delivery:

Pioneering surgical approach set to pave the way for hearing loss treatment

 

[IYIiKe]

This is pretty cool, but it's probably not something that will be commercially available this decade. I'm curious whether success in this area could help determine if CNS hyperactivity or dysfunction—when tinnitus is the only symptom—might improve with enhanced neural function. Alternatively, it's possible that the plastic changes leading to tinnitus generation won't simply reverse with neural healing.

I'm not familiar with the political climate in the U.K., but in the U.S., I anticipate that stem cell therapies will face significant hurdles in marketing and trials, especially with opposition targeting the NIH. I really hope politics don't interfere with the development of this promising therapy.

 

[Nick47]

Alternatively, it's possible that the plastic changes leading to tinnitus generation won't simply reverse with neural healing.

Cochlear implants often reduce tinnitus so hearing restoration likely will as well.

I'm not familiar with the political climate in the U.K., but in the U.S., I anticipate that stem cell therapies will face significant hurdles in marketing and trials, especially with opposition targeting the NIH. I really hope politics don't interfere with the development of this promising therapy.

The political climate has always been similar, but nowadays, people tend to largely ignore politics. In the past, there was much more division.

Many people now recognize that the main political parties are heavily influenced by international organizations like the WEF, the Gates Foundation, and the United Nations. As a result, it often feels like an illusion of choice, making it seem less worthwhile to argue or fall out over political differences.

 

[Joeseph Stope]

Cochlear implants often reduce tinnitus so hearing restoration likely will as well.

The political climate has always been similar, but nowadays, people tend to largely ignore politics. In the past, there was much more division.

Many people now recognize that the main political parties are heavily influenced by international organizations like the WEF, the Gates Foundation, and the United Nations. As a result, it often feels like an illusion of choice, making it seem less worthwhile to argue or fall out over political differences.

Government restrictions on research can certainly be a barrier in Europe. However, in the States, they often circumvent such restrictions by conducting experiments in third-world countries. While this approach might not be entirely ethical, it's not necessarily illegal.

Companies could justify their actions by pointing out that in many U.S. (and European) cities, people are already filling themselves with cocaine, crystal meth, and whatever else the pushers are selling. So, they might argue, What's the big deal?

 

[lello]

A new article, with some information on the delivery:

Pioneering surgical approach set to pave the way for hearing loss treatment

Forgive my ignorance, but from what I have read, the drug will be injected directly into the auditory nerve. Should I assume that it will target only the auditory nerve and not the hair cells?

I suffer from severe to profound sensorineural deafness caused by ototoxic drugs. Could this treatment be a suitable option for me?

 

[Nick47]

Should I assume that it will target only the auditory nerve and not the hair cells?

Yes, this is a stem cell treatment in which the cells are programmed to develop into auditory neurons, rather than hair cells or synapses. The condition often worsens with age.

 

[lello]

So, this is not suitable for sensorineural deafness like mine?

 

[Nick47]

So, this is not suitable for sensorineural deafness like mine?

@lello, it might help, as there could be nerve damage involved as well. What medication caused your hearing loss? Do you experience severe tinnitus? I reviewed your posts, but there isn't much information about your situation. Since this is the Rinri thread, please keep it brief here. You can continue the discussion on my profile page for general chat.

 

[lello]

I have been severely to profoundly deaf for over half a century. I discovered my hearing loss as a boy, and doctors have always told me that the cause was likely the streptomycin I was given as a child to treat another serious illness. They also believe the measles I had as a child may have contributed.

In a few years, I will probably have to stop using hearing aids and switch to a cochlear implant. However, if a cure were to become available in the meantime, I would be absolutely thrilled. I thought Rinri Therapeutics might be the right solution for me, but unfortunately, it is not.