Frequency Therapeutics — Hearing Loss Regeneration

[d'Wooluf]

Knowing that you monkeys thrive on talking about nothing, chew on this:

Frequency Therapeutics are looking for a Director of Biometrics:

https://careers.massbio.org/job/director-biometrics/46879620/

Biometrics in this context seems to mean biological statistics. If you read through the page, you could infer that Frequency Therapeutics are gearing up towards their next phase. A larger, more complex study maybe?

 

[andreimatei]

Nice find! They literally posted that today. Also, they posted this request for a Manager of Clinical Operations 2 days ago. That also might point to things going well as we head into Phase II...

https://careers.massbio.org/job/manager-clinical-operations/46864035/

 

[Rafaa]

When fluid/mucus collects in the middle ear, does that penetrate through the round window membrane? Or does it take a special liquid like what FX-322 is made from?

Just wondering with things like infection leading to tinnitus and general fluid collection in middle ear like what I get.

 

[d'Wooluf]

That also might point to things going well as we head into Phase II...

I sometimes wonder if they are in the process of applying for fast-track status from the FDA and if that's why they have been silent on the last clinical trial. They do seem to be preparing for large scale trials, but what time frame?

 

[Contrast]

When fluid/mucus collects in the middle ear, does that penetrate through the round window membrane? Or does it take a special liquid like what FX-322 is made from?

Just wondering with things like infection leading to tinnitus and general fluid collection in middle ear like what I get.

Did you go through with the injection at REGAIN?

 

[Rafaa]

Did you go through with the injection at REGAIN?

I don't qualify.

 

[Gorbeh3]

I sometimes wonder if they are in the process of applying for fast-track status from the FDA and if that's why they have been silent on the last clinical trial. They do seem to be preparing for large scale trials, but what time frame?

The thing is though, assuming the treatment works how do they keep this a secret for much longer?

How do you keep 12-20? People from letting it slip that a cure for hearing loss has been found for several months?

Let's say it was me in the trial, even if I myself did not tell anyone or let it leak on a forum, my family, friends, and coworkers would realize pretty quickly, probably within a couple weeks that my hearing had improved.

 

[JohnAdams]

The thing is though, assuming the treatment works how do they keep this a secret for much longer?

How do you keep 12-20? People from letting it slip that a cure for hearing loss has been found for several months?

Let's say it was me in the trial, even if I myself did not tell anyone or let it leak on a forum, my family, friends, and coworkers would realize pretty quickly, probably within a couple weeks that my hearing had improved.

Because people are dumb and don't realize how profound this is. Plus they expect other people to sound the alarm.

 

[incelitus]

The thing is though, assuming the treatment works how do they keep this a secret for much longer?

How do you keep 12-20? People from letting it slip that a cure for hearing loss has been found for several months?

Let's say it was me in the trial, even if I myself did not tell anyone or let it leak on a forum, my family, friends, and coworkers would realize pretty quickly, probably within a couple weeks that my hearing had improved.

People who don't have hearing loss yet couldn't care less about it, most of them see it as a natural thing which happens with age and something you HABITUATE to like grandma did or they think you can basically cure it with hearing aids so "whatever, stop complaining and be happy you aren't blind"

Also AFAIK this is for sudden hearing loss and acoustic trauma. Deafness isn't cured until everyone gets a cure.

 

[RB2014]

The thing is though, assuming the treatment works how do they keep this a secret for much longer?

How do you keep 12-20? People from letting it slip that a cure for hearing loss has been found for several months?

Let's say it was me in the trial, even if I myself did not tell anyone or let it leak on a forum, my family, friends, and coworkers would realize pretty quickly, probably within a couple weeks that my hearing had improved.

It because no one cares and no one sees it as a big deal until they get it. Most people are probably older too and not on the internet. With the Novartis trial we did see updates from one of the participants from a younger relative that also had the same condition. Plus they have probably had to sign a non-disclosure agreement. I don't think we will hear anything on this one until an official announcement is made.

 

[Street Novelist]

When? When is something going to happen? We keep waiting and waiting and waiting. The trial ended 2 months ago. For how much longer are we supposed to suffer?

 

[Contrast]

@davidlucchino

 

[JohnAdams]

When? When is something going to happen? We keep waiting and waiting and waiting. The trial ended 2 months ago. For how much longer are we supposed to suffer?

I'm pretty sure this type of technology is going to teach people more about the human body than they ever knew before as they now have a way to manipulate cells and make them do stuff. If they can tell a cell to act on command then they will figure out how to tell cancer to die and this is all starting with the cochlea (I think) All of the groups working in this are doing it for people like us and the more of us there are, the demand there will be. Basically I think eventually, maybe soon, a lot of good will come out of our suffering.

 

[d'Wooluf]

Let's say it was me in the trial, even if I myself did not tell anyone or let it leak on a forum, my family, friends, and coworkers would realize pretty quickly, probably within a couple weeks that my hearing had improved.

Yeah, probably. But the information is going to stay local unless the family/friend/coworker is co-incidentally contributing to a hearing loss/tinnitus forum. Established media isn't going to be interested in 'my cousin Alf's hearing has really improved' especially since Alf can't confirm because of an NDA. Also, most of the people on the trial probably function OK as far as the rest of the world is concerned. The effect to an outside observer wouldn't be that dramatic.

 

[Philip83]

This might have been touched in one of the 113 thread pages already - sorry for potentially asking again but;

I understand that FX-322 is supposed to regenerate hair cells. But what about nerve synapses? Are they also supposed to be restored?

 

[JohnAdams]

This might have been touched in one of the 113 thread pages already - sorry for potentially asking again but;

I understand that FX-322 is supposed to regenerate hair cells. But what about nerve synapses? Are they also supposed to be restored?

There is a video presentation from Frequency Therapeutics's Will McLean that says that the regenerated cells also have new ribbon synapses. Sorry I forgot where he states it, the whole video is worth a watch.



There's another video presentation from Dr. Robert Jackler, who I think is in charge of Stanford's Heller Lab, and he states that the auditory nerve fibers regrow and connect to the newly regenerated hair cell/supporting cells and calls it a "God-darned miracle". Watch from 28:50.

 

[jeff W]

I believe McLean stated that they had better results in vitro growing vestibular hair cells but I don't think there's a way to get the substance into that part of the ear. I could be wrong. Dana White said PRP cured his Meniere's disease but we don't know if he had damage to his vestibular hair cells or a nerve(s) and exactly what the PRP acted on.

Orthokine is NOT standard PRP.

 

[JohnAdams]

Orthokine is NOT standard PRP.

Yes, I have since learned that. Thanks.

 

[jeff W]

Yes, I have since learned that. Thanks.

I have been absent for a while, have you contacted anyone from the Frequency Therapeutics trial?

 

[JohnAdams]

I have been absent for a while, have you contacted anyone from the Frequency Therapeutics trial?

Tell me how and I will. They haven't really revealed anything new in a long time.

 

[Phendran]

Basically I think eventually, maybe soon, a lot of good will come out of our suffering.

These words felt really good. Thank you.

There is much to be said for the understanding of others in suffering, and suffering with others.

I have hope as well.

 

[Philip83]

There is a video presentation from Frequency Therapeutics's Will McLean that says that the regenerated cells also have new ribbon synapses. Sorry I forgot where he states it, the whole video is worth a watch.

Cheers for this, hadn't seen it before. I guess he's also mentioning the synapses at 17:00. Looks promising!

 

[Flamingo1]

Interesting...
http://xconomy.com/boston/2019/02/06/frequency-chief-medical-officer-weber-jumps-to-decibel-therapeutics/

 

[Jim51042]

Interesting...

Any speculation on the cause of the move??

 

[Piney]

What's interesting is how we know when these people switch from company to company for the next pay check, but we never hear any concrete news or info on results or accurate dates.

The conference data and investor data seems to be rock solid though.

 

[Flamingo1]

What's interesting is how we know when these people switch from company to company for the next pay check, but we never hear any concrete news or info on results or accurate dates.

Hopefully the secrecy is to maintain a competitive advantage and not because there is trouble in la la Land.

 

[Philip83]

Americans only I think... website tells me I'm region blocked.

 

[WickedCarnival]

That's not how it works.
The drug is injected via the eardrum into the middle ear and then diffuses through the round window membrane.
Go look at a 3D anatomical model of the ear, you will see that getting a needle into the eardrum and then the round window membrane would be extremely difficult.

Thank you for the correction. In regards to Otomagnetics, they can get particles more effectively into the cochlea than with injection.

 

[WickedCarnival]

I believe McLean stated that they had better results in vitro growing vestibular hair cells but I don't think there's a way to get the substance into that part of the ear. I could be wrong. Dana White said PRP cured his Meniere's disease but we don't know if he had damage to his vestibular hair cells or a nerve(s) and exactly what the PRP acted on.

Check out the video on how Otomagnetics proposes to get the particles into the inner ear more effectively than with injection:



http://otomagnetics.net/

 

[Johan_L]

Interesting...
http://xconomy.com/boston/2019/02/06/frequency-chief-medical-officer-weber-jumps-to-decibel-therapeutics/

Any speculation on the cause of the move??

What's interesting is how we know when these people switch from company to company for the next pay check, but we never hear any concrete news or info on results or accurate dates.

The conference data and investor data seems to be rock solid though.

This was discussed a couple of weeks ago. Frequency Therapeutics has had their current CMO since Spring 2018, so Weber did not leave them recently.

http://www.frequencytx.com/news-events/news-events-press-release-04-13-2018.php