Frequency Therapeutics — Hearing Loss Regeneration

#3,361
Knowing that you monkeys thrive on talking about nothing, chew on this:

Frequency Therapeutics are looking for a Director of Biometrics:

https://careers.massbio.org/job/director-biometrics/46879620/

Biometrics in this context seems to mean biological statistics. If you read through the page, you could infer that Frequency Therapeutics are gearing up towards their next phase. A larger, more complex study maybe?
 
#3,363
When fluid/mucus collects in the middle ear, does that penetrate through the round window membrane? Or does it take a special liquid like what FX-322 is made from?

Just wondering with things like infection leading to tinnitus and general fluid collection in middle ear like what I get.
 
#3,364
andreimatei said:
That also might point to things going well as we head into Phase II...
Click to expand...
I sometimes wonder if they are in the process of applying for fast-track status from the FDA and if that's why they have been silent on the last clinical trial. They do seem to be preparing for large scale trials, but what time frame?
 
#3,365
Rafaa said:
When fluid/mucus collects in the middle ear, does that penetrate through the round window membrane? Or does it take a special liquid like what FX-322 is made from?

Just wondering with things like infection leading to tinnitus and general fluid collection in middle ear like what I get.
Click to expand...
Did you go through with the injection at REGAIN?
 
#3,367
d'Wooluf said:
I sometimes wonder if they are in the process of applying for fast-track status from the FDA and if that's why they have been silent on the last clinical trial. They do seem to be preparing for large scale trials, but what time frame?
Click to expand...
The thing is though, assuming the treatment works how do they keep this a secret for much longer?

How do you keep 12-20? People from letting it slip that a cure for hearing loss has been found for several months?

Let's say it was me in the trial, even if I myself did not tell anyone or let it leak on a forum, my family, friends, and coworkers would realize pretty quickly, probably within a couple weeks that my hearing had improved.
 
#3,368
Gorbeh3 said:
The thing is though, assuming the treatment works how do they keep this a secret for much longer?

How do you keep 12-20? People from letting it slip that a cure for hearing loss has been found for several months?

Let's say it was me in the trial, even if I myself did not tell anyone or let it leak on a forum, my family, friends, and coworkers would realize pretty quickly, probably within a couple weeks that my hearing had improved.
Click to expand...
Because people are dumb and don't realize how profound this is. Plus they expect other people to sound the alarm.
 
#3,369
Gorbeh3 said:
The thing is though, assuming the treatment works how do they keep this a secret for much longer?

How do you keep 12-20? People from letting it slip that a cure for hearing loss has been found for several months?

Let's say it was me in the trial, even if I myself did not tell anyone or let it leak on a forum, my family, friends, and coworkers would realize pretty quickly, probably within a couple weeks that my hearing had improved.
Click to expand...
People who don't have hearing loss yet couldn't care less about it, most of them see it as a natural thing which happens with age and something you HABITUATE to like grandma did or they think you can basically cure it with hearing aids so "whatever, stop complaining and be happy you aren't blind"

Also AFAIK this is for sudden hearing loss and acoustic trauma. Deafness isn't cured until everyone gets a cure.
 
#3,370
Gorbeh3 said:
The thing is though, assuming the treatment works how do they keep this a secret for much longer?

How do you keep 12-20? People from letting it slip that a cure for hearing loss has been found for several months?

Let's say it was me in the trial, even if I myself did not tell anyone or let it leak on a forum, my family, friends, and coworkers would realize pretty quickly, probably within a couple weeks that my hearing had improved.
Click to expand...
It because no one cares and no one sees it as a big deal until they get it. Most people are probably older too and not on the internet. With the Novartis trial we did see updates from one of the participants from a younger relative that also had the same condition. Plus they have probably had to sign a non-disclosure agreement. I don't think we will hear anything on this one until an official announcement is made.
 
#3,373
Street Novelist said:
When? When is something going to happen? We keep waiting and waiting and waiting. The trial ended 2 months ago. For how much longer are we supposed to suffer?
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I'm pretty sure this type of technology is going to teach people more about the human body than they ever knew before as they now have a way to manipulate cells and make them do stuff. If they can tell a cell to act on command then they will figure out how to tell cancer to die and this is all starting with the cochlea (I think) All of the groups working in this are doing it for people like us and the more of us there are, the demand there will be. Basically I think eventually, maybe soon, a lot of good will come out of our suffering.
 
#3,374
Gorbeh3 said:
Let's say it was me in the trial, even if I myself did not tell anyone or let it leak on a forum, my family, friends, and coworkers would realize pretty quickly, probably within a couple weeks that my hearing had improved.
Click to expand...
Yeah, probably. But the information is going to stay local unless the family/friend/coworker is co-incidentally contributing to a hearing loss/tinnitus forum. Established media isn't going to be interested in 'my cousin Alf's hearing has really improved' especially since Alf can't confirm because of an NDA. Also, most of the people on the trial probably function OK as far as the rest of the world is concerned. The effect to an outside observer wouldn't be that dramatic.
 
#3,375
This might have been touched in one of the 113 thread pages already - sorry for potentially asking again but;

I understand that FX-322 is supposed to regenerate hair cells. But what about nerve synapses? Are they also supposed to be restored?
 
#3,376
Philip83 said:
This might have been touched in one of the 113 thread pages already - sorry for potentially asking again but;

I understand that FX-322 is supposed to regenerate hair cells. But what about nerve synapses? Are they also supposed to be restored?
Click to expand...
There is a video presentation from Frequency Therapeutics's Will McLean that says that the regenerated cells also have new ribbon synapses. Sorry I forgot where he states it, the whole video is worth a watch.



There's another video presentation from Dr. Robert Jackler, who I think is in charge of Stanford's Heller Lab, and he states that the auditory nerve fibers regrow and connect to the newly regenerated hair cell/supporting cells and calls it a "God-darned miracle". Watch from 28:50.

 
#3,377
JohnAdams said:
I believe McLean stated that they had better results in vitro growing vestibular hair cells but I don't think there's a way to get the substance into that part of the ear. I could be wrong. Dana White said PRP cured his Meniere's disease but we don't know if he had damage to his vestibular hair cells or a nerve(s) and exactly what the PRP acted on.
Click to expand...
Orthokine is NOT standard PRP.
 
#3,382
JohnAdams said:
There is a video presentation from Frequency Therapeutics's Will McLean that says that the regenerated cells also have new ribbon synapses. Sorry I forgot where he states it, the whole video is worth a watch.

Click to expand...

Cheers for this, hadn't seen it before. I guess he's also mentioning the synapses at 17:00. Looks promising!
 
#3,385
What's interesting is how we know when these people switch from company to company for the next pay check, but we never hear any concrete news or info on results or accurate dates.

The conference data and investor data seems to be rock solid though.
 
#3,386
Piney said:
What's interesting is how we know when these people switch from company to company for the next pay check, but we never hear any concrete news or info on results or accurate dates.
Click to expand...
Hopefully the secrecy is to maintain a competitive advantage and not because there is trouble in la la Land.
 
#3,388
JohnAdams said:
That's not how it works.
The drug is injected via the eardrum into the middle ear and then diffuses through the round window membrane.
Go look at a 3D anatomical model of the ear, you will see that getting a needle into the eardrum and then the round window membrane would be extremely difficult.
Click to expand...
Thank you for the correction. In regards to Otomagnetics, they can get particles more effectively into the cochlea than with injection.
 
#3,389
JohnAdams said:
I believe McLean stated that they had better results in vitro growing vestibular hair cells but I don't think there's a way to get the substance into that part of the ear. I could be wrong. Dana White said PRP cured his Meniere's disease but we don't know if he had damage to his vestibular hair cells or a nerve(s) and exactly what the PRP acted on.
Click to expand...
Check out the video on how Otomagnetics proposes to get the particles into the inner ear more effectively than with injection:



http://otomagnetics.net/
 
#3,390
Flamingo1 said:
Interesting...
http://xconomy.com/boston/2019/02/06/frequency-chief-medical-officer-weber-jumps-to-decibel-therapeutics/
Click to expand...
Jim51042 said:
Any speculation on the cause of the move??
Click to expand...
Piney said:
What's interesting is how we know when these people switch from company to company for the next pay check, but we never hear any concrete news or info on results or accurate dates.

The conference data and investor data seems to be rock solid though.
Click to expand...
This was discussed a couple of weeks ago. Frequency Therapeutics has had their current CMO since Spring 2018, so Weber did not leave them recently.

http://www.frequencytx.com/news-events/news-events-press-release-04-13-2018.php
 

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