Not too sure.
That's exactly what they are trying to find out in their current trial.
You are correct, but I wouldn´t disregard that Audion also could be repeatable as treatment. Time will tell.
Euthanise, dissect, count. Too time-consuming, so they'll probably just re-test your hearing.
I would say that after the treatment they test the hearing with an audiogram and word scoring. That's what they did in the first trial and found out improvements in hearing.
I know that they will be doing Phase 2a later this year. So if this ends up being successful how many phases are there before it comes into the market?
This depends on what they find in Phase 2a. The dose may need further tweaking before Phase 3. Hopefully, information in September will give us a better idea.
Hopefully in September they will mention whether the participants whose hearing improved also experienced a reduction in their tinnitus volume, or better yet their tinnitus went completely away.
I agree with that. But it is impressing that the initial test with the drug seemed to be so successful that even with a low (safety) dosage they experienced improvements in hearing!
Well, the chances are that most of those who are said to not have hearing loss indeed do have some hearing loss. The problem is that hearing usually isn't measured over 8000 Hz and so someone could have hearing loss in the higher frequencies. Also there is hidden hearing loss where single tones can be heard but speech processing and hearing in background noise becomes a struggle.
Don't forget the number of people who potentially need this cure (young people who are heavy headphone users, who attend loud parties, go to loud concerts, etc. and also people who have had a sudden hearing loss).
I think synapses do form with the new hair cells.
If they say "improvements in hearing", I'd say yes. But maybe I am wrong about that?
Not all your hair cells are intact. Humans start to lose hair cells starting from a young age. IMO, if this works whatever amount you have lost will regenerate with new synapses adding to improved hearing in *those* regenerated hair cells. Overall, net increase either way.
For the record, nobody here truly knows the timeline here, this is uncharted territory for the FDA and medical world.
In this case I hope that for minor hearing loss with heavy synapses damages, additional growth factor therapy provided by hidden hearing loss researchers could be available, so that sound clarity and dynamics become optimum, as long as mixed therapies (Frequency + NT3 neurotrophin for instance) could work together without risks.
If it came out in 2021 it would be so good. The only concern I have is how long would it take to release it to other countries .
Same lol. I think REGAIN should finish Phase 2 by the end of the year and release their results next year. So they are definitely more ahead than Frequency Therapeutics. There is now a lot of competition which is a good thing because the first company that releases it will gain a lot of revenue if it actually works, especially if it makes tinnitus and hyperacusis go away.
There are also some others as well such as Decibel Therapeutics and Otonomy but I think REGAIN and Frequency Therapeutics are further ahead in terms of their phases.
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