Frequency Therapeutics — Hearing Loss Regeneration

[JohnAdams]

Are REGAIN and Frequency Therapeutics the two companies leading the way to cure hearing loss or are there others to keep an eye on also?

Otonomy.

 

[JohnAdams]

This, like everything else, is moving too slowly.

 

[JoNo78]

This, like everything else, is moving too slowly.

Better slow than nothing.... And I really hope for a breakthrough! I want to be able to hear!

 

[briano]

Having REGAIN, Frequency Therapeutics and Otonomy all working on cures are a lot more options than we had just a few years ago. I personally did the LLLT for 2 years. Although it calmed down my tinnitus, it never helped me regain my hearing loss. I'm keeping my eye on these 3.

 

[FGG]

Better slow than nothing.... And I really hope for a breakthrough! I want to be able to hear!

Me too. Being able to hear music again would be the most joyful moment in my life.

 

[urgentresearch]

Do you reckon Frequency Therapeutics have started their Phase 2 trials yet?

Phase 2 has not started yet but when it does they will announce it.

 

[urgentresearch]

Having REGAIN, Frequency Therapeutics and Otonomy all working on cures are a lot more options than we had just a few years ago. I personally did the LLLT for 2 years. Although it calmed down my tinnitus, it never helped me regain my hearing loss. I'm keeping my eye on these 3.

Fun fact: there are 43 companies currently working on hearing restoration drugs right now

 

[JohnAdams]

Better slow than nothing.... And I really hope for a breakthrough! I want to be able to hear!

I just would think that considering how many vets there are with tinnitus/hearing loss that the ATA would be working with the government to pour a lot of money into this instead of treating it like any other pharma company making any other drug. Considering that the ATA's head, LaGuinn Sherlock, was a research audiologist with the U.S. Army Public Health Center you'd think something like that would be happening.

 

[Bobbette]

I apologize for going off tangent here for a moment!

Considering that the ATA's head, LaGuinn Sherlock, was a research audiologist with the U.S. Army Public Health Center you'd think something like that would be happening.

You'd think wrong. LaGuinn Sherlock believes everyone will habituate and there's no need for drug treatments. She's a disgrace in my book!

https://www.tinnitustalk.com/thread...-is-this-the-right-message-to-send-out.32191/

 

[JoNo78]

Fun fact: there are 43 companies currently working on hearing restoration drugs right now

43 companies?? Please list them.

 

[Lucifer]

If we do get rid of our tinnitus by having our hair cells regenerated, would our ears still be sensitive to certain sounds e.g., blenders, vacuuming, travelling on planes etc.?

 

[Aleksa Uzunovic]

My opinion is that, in terms of practical treatment we should mostly keep our eyes on Regain. They are moving much faster than Frequency. They will be done with phase 2 by the end of the year, that's a massive progress. So our best bet to having a cure in a year or two is Regain. Forget Frequency, they're a toast if Regain proves to have have a functioning cure in the Phase 2.

 

[Ken219]

If we do get rid of our tinnitus

It would be good to have hearing restored but my prayers go to them finding a tinnitus cure.

 

[Ken219]

LaGuinn Sherlock believes everyone will habituate and there's no need for drug treatments.

I see what you mean. Sounds like a wasted position and money. Our goal is to habituate! We pray for researchers to find a cure!

'Dr. Sherlock works at Walter Reed National Military Medical Center for the US Army Hearing Program as a research audiologist. Her current research interests include the effects of tinnitus on concentration, the efficacy of tinnitus treatment programs, and the evaluation and management of hyperacusis.'

 

[parsky]

My opinion is that, in terms of practical treatment we should mostly keep our eyes on Regain. They are moving much faster than Frequency. They will be done with phase 2 by the end of the year, that's a massive progress. So our best bet to having a cure in a year or two is Regain. Forget Frequency, they're a toast if Regain proves to have have a functioning cure in the Phase 2.

You are assuming both will provide equal results. The literature suggests FX3-22 "cocktail" of small molecules will produce better results than REGAIN's sole use of just a gamma secretase inhibitor.

How this translates in vivo for humans we don't know yet, but I think your conclusion that FX-322 is toast is a bit presumptuous, at this point in time, if they don't reach the finish line first.

 

[urgentresearch]

43 companies?? Please list them.

I don't have them in list format at the moment but when I get a chance I will do some organizing and post them here.

 

[JoNo78]

You are assuming both will provide equal results. The literature suggests FX3-22 "cocktail" of small molecules will produce better results than REGAIN's sole use of just a gamma secretase inhibitor.

How this translates in vivo for humans we don't know yet, but I think your conclusion that FX-322 is toast is a bit presumptuous, at this point in time, if they don't reach the finish line first.

Well, I think that we have to wait and see... I am optimistic about both of them, but especially so about FX-322. Don't ask why, but it sounds bit better... ;-) but hey, the more research we have, the better it is, or? BTW: Cocktails are nice ;-)

 

[Aleksa Uzunovic]

You are assuming both will provide equal results. The literature suggests FX3-22 "cocktail" of small molecules will produce better results than REGAIN's sole use of just a gamma secretase inhibitor.

How this translates in vivo for humans we don't know yet, but I think your conclusion that FX-322 is toast is a bit presumptuous, at this point in time, if they don't reach the finish line first.

I don't care, no matter what kind of improvement, everyone will throw their money at REGAIN if they release their treatment first, even if it doesn't recover hearing fully but only partially. Those lame asses at Frequency Therapeutics will make $0 if they keep with this pace of progress.

 

[Hayls32]

43 companies?? Please list them.

Here is a link to Action on Hearing loss. If you read through it there is a link to a spreadsheet of all the companies doing all sorts... hope it helps

https://www.actiononhearingloss.org...log/treatments-for-hearing-loss-and-tinnitus/

 

[JoNo78]

Here is a link to Action on Hearing loss. If you read through it there is a link to a spreadsheet of all the companies doing all sorts... hope it helps

https://www.actiononhearingloss.org...log/treatments-for-hearing-loss-and-tinnitus/

Thank you That's a good site! Well, so let's hope! I think that in the near future we will have the cure!

 

[briano]

I'm hoping that we get to hear from the people involved in the trials. I'd like for them to explain in their own words what the results were and how the drugs made them feel.

 

[Bobbette]

I'm hoping that we get to hear from the people involved in the trials. I'd like for them to explain in their own words what the results were and how the drugs made them feel.

They have all had to sign NDAs (non-disclosure agreements).

 

[Jab4]

They have all had to sign NDAs (non-disclosure agreements).

You can't keep that a secret, people talk.

 

[spedgas]

You can't keep that a secret, people talk.

They've done a pretty good job so far. As these trials get bigger that has to get harder though.

 

[Lucifer]

They've done a pretty good job so far. As these trials get bigger that has to get harder though.

How does fast tracking work? After they are done with Phase 2 and if it's successful, how fast - after Phase 3 is done - can they release the drug to the market?

 

[JoNo78]

You are assuming both will provide equal results. The literature suggests FX3-22 "cocktail" of small molecules will produce better results than REGAIN's sole use of just a gamma secretase inhibitor.

How this translates in vivo for humans we don't know yet, but I think your conclusion that FX-322 is toast is a bit presumptuous, at this point in time, if they don't reach the finish line first.

Well, as far as I have understood, Frequency Therapeutics had only patients with massive hearing loss in their trial, whereas REGAIN tested their drug in people with mild to moderate hearing loss. That's a difference of the research/treatment... Or do I interpret it wrong?

 

[Lucifer]

Someone posted this on Reddit:

I worked on this clinical trial!! This makes me so happy to see the excitement. I don't really know how much I can say as far as results/patient testimony, but it was the best study I have ever worked on. So rewarding and a great great company!

What is the likelihood that they will mention that this drug actually reduced or cured their tinnitus at the September event?

 

[Lucifer]

Well, as far as I have understood, Frequency Therapeutics had only patients with massive hearing loss in their trial, whereas REGAIN tested their drug in people with mild to moderate hearing loss. That's a difference of the research/treatment... Or do I interpret it wrong?

Just did some research and you're right. I really hope these companies actually do really well in Phase 2 and 3 and they actually do work in curing tinnitus or reducing it a lot. I don't want this to be another AM-101.

 

[JoNo78]

 

[briano]

Someone posted this on Reddit:

I worked on this clinical trial!! This makes me so happy to see the excitement. I don't really know how much I can say as far as results/patient testimony, but it was the best study I have ever worked on. So rewarding and a great great company!

What is the likelihood that they will mention that this drug actually reduced or cured their tinnitus at the September event?

I love hearing this!