Well, maybe. More than one person had some improvement in hearing. But we don't know if that is due to new cells, new cells connecting to existing nerve, new cells AND a new nerve growth or just a restoration of the ribbon synapse between existing cells and existing nerves. And we won't know until those people are dead and they also testament their bodies to science so that we get to carve into their inner ears.
Just curious. Where did you see that 2 people had positive results. I must have missed that somewhere along the line.
You can read it in a press release note on Frequancy Therapeutics home page.
Not JUST 2. At least 2. Multiple implies more than 1, which is AT LEAST 2. But there could be more.
I stand corrected. I was being emotional as opposed to being scientific. I agree with you. Ooops.
That's at least 2 out of quite a small number of participants who got the FX-322.
I was thinking on this last night. I believe it is possibly for business purposes - e.g. the less competitors know the less well informed they are to invest in similar or alternative medicinal strategies for the same (e.g. hearing loss related), or other purposes. Having potential competitors less informed is always an effective business strategy, particularly at the investment level that the kind business invested in; an extended development-phase product. So I imagine this is likely just part of managed information release.
There's going to be an event on September 18th, 2019 and that's where they will talk about the trials and hopefully mention tinnitus and hyperacusis being resolved.
You're right, I'm not that old! I think I was trying to use hyperbole to make a point.
I had to google hyperbole (my vocabulary isn't that great) I hope you are doing reasonably well and if not some technology in the near future helps. I seemed to be helped short term with steroids but mine might be partially neck/TMJ related. Loud hissing atm. I have HF hearing loss. Will receive Audicus Clara HA soon. I lost my right HA and traded up. I can hear okay, it's mainly the tinnitus bothering me.
My latest audiogram. I almost fell asleep during it. I don't know how to interpret them that well. They wanted to sell me Starkey hearing aids which were very high priced, so I went with Audicus Clara instead. Tinnitus didn't seem to bother me that day. ENT sucked quite a bit of wax out of my ears.
Your audiogram, whilst not great, is not that bad either. Do you really need hearing aids or do you like wearing them to enhance perception of upper frequencies? Or do they actually help with tinnitus masking?
I'm only really using them because I sometimes have severe static noise when I wake up, like right now. It could be related to my neck/tmj, I'm not sure. Just looking for relief of some kind for my typical static.
Audicus told me today that they were able to reverse ship my other hearing aid so now I will have my old pair as backups. They just have to reprogram it again as they wiped out the programming to my audiogram.
They have a golden period between the first annoucement and the end of phase 3 when they can make claims to increase their stock prices, regardless if the drug works or not.
They all do it. It is called puffing in legal terms and is not illegal. They are looking for a cure, and are chasing down what they deduce will be a chance at some type of treatment, but they cannot be sure until it is tested. So they make extremely positive and reaching announcements. Sales and marketing is alive in the drug development world.
The money Frequency Therapeutics got in their startup round was from private investors. They have never been publicly traded. Generally, private investors want a little more than puffed up optimism to invest millions in a biotech.
Public or private they are still raising many many millions from the press releases stating that they can cure hearing loss. I am not convinced that they have the magical miracle cure they are saying they have. I really hope they do... As a professional musician I hope they do. I really do. But after the ALS press releases and then watching my family member wither away to nothing I am cautious with my hopes.
I can't comment much on Brainstorm but I followed a different biotech Sarepta Therapeutics, for years, and their gene altering drug Eteplirsen quite closely as the trials were unfolding. If you read their statements, they said the drug increases dystropin and therefore improves Ducchene Muscular Dystrophy to the point where it is more like Becker's (huge improvement for these kids). All claims were "this drug improves dystropin production" and "walk test results improved on this drug." And it does work. The drug is a breakthrough. By the way, Eteplirsen works at the genetic level as well.
).I will believe it when I can hear it.I can't comment much on Brainstorm but I followed a different biotech Sarepta Therapeutics, for years, and their gene altering drug Eteplirsen quite closely as the trials were unfolding. If you read their statements, they said the drug increases dystropin and therefore improves Ducchene Muscular Dystrophy to the point where it is more like Becker's (huge improvement for these kids). All claims were "this drug improves dystropin production" and "walk test results improved on this drug." And it does work. The drug is a breakthrough. By the way, Eteplirsen works at the genetic level as well.
Perhaps with Brainstorm, the CSF markers they evaluated (what I saw them reporting in the search I did on them) were not a good marker for the effectiveness of treating ALS or it is too heterogeneous of a disease. It wasn't false to report the CSF changes but perhaps not all that relevant (unfortunately for your family member
We are way behind on hearing loss research but we *do* know functional hair cells are directly related to hearing ability. I see this as a huge difference between Frequency Therapeutics and Brainstorm. Frequency Therapeutics has shown in vitro it can regrow human cochlear hair cells. If they can show changes in audiogram after treatment, their claims are credible and they have accomplished hearing regeneration. There isn't as much wiggle room in their findings here. Either people could hear better or they couldn't.
I just have a good feeling about this company and what they are saying is true and this drug does actually work. We just don't know how much of an improvement to our hearing we will get using this drug. You're right if they mislead people they lose investors and their reputation is on the line no doubt.
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