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Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
- Start date
MemberI don't mean to poo poo on this parade, but I think hair cell regeneration will only get us so far. We are also going to need our synapses and nerves regenerated/repaired. Dr. Robert Jackler from Stanford University stated that nerves regenerate to connect to new hair cells but I really am starting to think that we are going to need combinations of hair cell regeneration, synapse repair and nerve repair to get totally back to silence.
I am now researching substances that could help us achieve this.
I'm starting here:
"Myelination of peripheral nerves by Schwann cells requires coordinate regulation of gene repression as well as gene activation. Several chromatin remodeling pathways critical for peripheral nerve myelination have been identified, but the functions of histone methylation in the peripheral nerve have not been elucidated. To determine the role of histone H3 Lys27 methylation, we have generated mice with a Schwann cell-specific knock-out of Eed, which is an essential subunit of the polycomb repressive complex 2 (PRC2) that catalyzes methylation of histone H3 Lys27. Analysis of this mutant revealed no significant effects on early postnatal development of myelin. However, its loss eventually causes progressive hypermyelination of small-diameter axons and apparent fragmentation of Remak bundles. These data identify the PRC2 complex as an epigenomic modulator of mature myelin thickness, which is associated with changes in Akt phosphorylation. Interestingly, we found that Eed inactivation causes derepression of several genes, e.g., Sonic hedgehog (Shh) and Insulin-like growth factor-binding protein 2 (Igfbp2), that become activated after nerve injury, but without activation of a primary regulator of the injury program, c-Jun. Analysis of the activated genes in cultured Schwann cells showed that Igfbp2 regulates Akt activation. Our results identify an epigenomic pathway required for establishing thickness of mature myelin and repressing genes that respond to nerve injury."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452560/
I am now researching substances that could help us achieve this.
I'm starting here:
"Myelination of peripheral nerves by Schwann cells requires coordinate regulation of gene repression as well as gene activation. Several chromatin remodeling pathways critical for peripheral nerve myelination have been identified, but the functions of histone methylation in the peripheral nerve have not been elucidated. To determine the role of histone H3 Lys27 methylation, we have generated mice with a Schwann cell-specific knock-out of Eed, which is an essential subunit of the polycomb repressive complex 2 (PRC2) that catalyzes methylation of histone H3 Lys27. Analysis of this mutant revealed no significant effects on early postnatal development of myelin. However, its loss eventually causes progressive hypermyelination of small-diameter axons and apparent fragmentation of Remak bundles. These data identify the PRC2 complex as an epigenomic modulator of mature myelin thickness, which is associated with changes in Akt phosphorylation. Interestingly, we found that Eed inactivation causes derepression of several genes, e.g., Sonic hedgehog (Shh) and Insulin-like growth factor-binding protein 2 (Igfbp2), that become activated after nerve injury, but without activation of a primary regulator of the injury program, c-Jun. Analysis of the activated genes in cultured Schwann cells showed that Igfbp2 regulates Akt activation. Our results identify an epigenomic pathway required for establishing thickness of mature myelin and repressing genes that respond to nerve injury."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452560/
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But then what do you make of the recent trial where Frequency Therapeutics stated improved hearing and word/audiometry scores in patients given the treatment?
Coleoptere
Member
Ken219
Member
I am so sorry. I am desperate too. I cry. I pray. I have habituated after several relapses. Have you ever had okay times in 17 years?
There could still be damage to the auditory nerve that is generating a tinnitus sound. Restoring hearing surely will diminish tinnitus but my comment was about curing us all together.
Coleoptere
Member
Ok, if I read this I think you are worse off than me. There are days that I'm desperate due to tinnitus. But generally I keep myself busy and I'm able to put it away.
Ken219
Member
That may be true but it is all subjective. I hope you have more good days. I wish you well and pray for better treatments or a cure.
- Jun 26, 2014
- 2,264
- Tinnitus Since
- 11/2013
- Cause of Tinnitus
- Drugs barotrauma
I guess there has to be enough conviction that this is the right way, most people/investors aren't convinced thus far, otherwise there would be more capital. I know you're sold but yeah, that means nothing, have to convince the smart money, and not just a bunch of yahoos on Tinnitus Talk that think they have found the cure.
You think the smart money skipped this over? Time to get a grip on reality maybe?
FYI:
"Frequency secured $42 million in funding through a series B round this past January to advance FX-322's clinical testing and the company's regenerative medicine work in other applications.
The round was led by Taiwania Capital Management and Axil Capital, a healthcare-focused venture fund spun out of Mizuho Securities. New backers included Yonjin Capital and DF Investments, while previous investors Polaris Founders Capital, Alexandria Venture Investments, CoBro Ventures, Korea Investment Partners and Emigrant Capital also participated, bringing the company's total funding to $87 million."
Source: https://www.fiercebiotech.com/biote...sults-for-small-molecule-hearing-loss-therapy
That's 87 million so far. Their presentation in September will probably also be a sales pitch to investors, so this will be the next step to get more "smart money". Innovational science is doing exactly what you are talking about: turning hearing restoration into reality, and Frequency Therapeutics isn't the only one doing it.
Please see this website:
www.hearinglosstreatmentreport.com
Looking forward to you being proven wrong... as well as getting my FX-322 SHOT. I don't share your cynicism my friend.
Problem is we are still stuck in the same old paradigm. Many still believe hearing aids, TRT, and CBT are the only possible treatments for hearing loss and tinnitus. All three of these are multimillion dollar industries that would lose a lot of revenue if this becomes reality. The general public isn't even aware of the possibilities of hearing regeneration.
Unless you have hearing loss a treatment or cure is not exactly at the forefront of your mind.
Many older people care just looking for the quick fix hearing aids offer so they can just get on with their lives.
Not to mention the stigma that still surrounds hearing loss. Unlike vision issues there is still shame and embarrassment that many with hearing loss harbor. Often there is a questioning of someone's intellectual capabilities if they have hearing loss.
If a treatment or cure does come available it will truly be nothing short of miraculous.
Unless you have hearing loss a treatment or cure is not exactly at the forefront of your mind.
Many older people care just looking for the quick fix hearing aids offer so they can just get on with their lives.
Not to mention the stigma that still surrounds hearing loss. Unlike vision issues there is still shame and embarrassment that many with hearing loss harbor. Often there is a questioning of someone's intellectual capabilities if they have hearing loss.
If a treatment or cure does come available it will truly be nothing short of miraculous.
You're off by a few orders of magnitude. It's a multi-billion dollar industry.
That's not unusual: the public doesn't know of treatments that haven't reached their MDs, unless they are particularly interested in scientific research and look for stuff on their own (like a few people in here do). And so far, since no treatment has passed all of the requirements to reach an MD, it's not surprising that nobody knows about it.
SergioN
Member
- Feb 8, 2019
- 31
- Tinnitus Since
- 25/07/2005
- Cause of Tinnitus
- Acoustic trauma + ototoxicity
But billions of dollars will be spent in regenerative drugs instead of nanotechnology. If drugs work, new companies will fight for those billions of dollars now in hands of current actors. Tell me if I am wrong.
Or current industry will pay Frequency Therapeutics to voluntarily fail? It will be a drama.
Or current industry will pay Frequency Therapeutics to voluntarily fail? It will be a drama.
Street Novelist
Member
- Apr 2, 2018
- 290
- Tinnitus Since
- February 2018
- Cause of Tinnitus
- Listening to loud music through headphones
God, when will they say something! September is such a wait, especially if the next trial isn't this year.
Ken219
Member
3M should be contributing $100,000,000.00 a year to tinnitus research after they knowingly sold the world defective earplugs!
It could be possible that they already have started Phase 2a trials. But what would worry me is that instead of Phase 3 it will be Phase 2b next.
If it does work and people are desperate they should release it asap
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Fabrikat
Member
- May 1, 2017
- 416
- Tinnitus Since
- 1973
- Cause of Tinnitus
- Otosclerosis then volume then viral infection
Next to FX-322 actually failing, this is the most frightening scenario of all.
Buying out a new innovation to protect an old existing industry, especially in the realm of human health, is one of the most sinister and evil aspects of capitalism.
It's really a human rights issue, but sadly, I doubt anyone would legislate or control to prevent it.
Well, we as a community aren't making enough noise about this to capitalize on the situation. You certainly don't see the American Tinnitus Association making a peep about it.
- Jun 13, 2019
- 1,108
- Tinnitus Since
- 10/2018
- Cause of Tinnitus
- Started with a cold, possibly worsened by medication/noise
Even if they pay them to fail the research is still there, someone will sneak it out and re-start somewhere else, so it could be a big delay but not the end of it. And it's not necessarily going to work for everyone, so nanotechnology would be still useful to develop. Also, let's not forget that we don't have just FX-322, we can put some hope also on REGAIN, and that is sponsored by the European commission, so it's harder to derail probably.
https://www.regainyourhearing.eu/
Ken219
Member
Here is what makes it worse. 3M would still be selling the defective earplugs if it wasn't for 'whistleblower brought forward allegations that the company knowingly sold the U.S. military defective earplugs'
Exactly, too many players and many potential billions for the first successful company.
Even Hough Ear Institute has their own hearing regeneration study going and I believe are not for profit/potential bribery.
Ken219
Member
It's a problem. Doctors are comfortable offering these treatments and it will take time to adapt to something new. When you talk about ear regeneration or bimodal neuromodulation, they underestimate them as pilot tests or things without scientific backing. Then they offer to do TRT or Sound Therapy (ha-ha!).
Sure, but the generic company wouldn't go for it if it was that much more profitable to not accept the bribe as it would be here.
Also, unlike the generic drug example the reputations of some big name researchers are at stake here.
The problem is that tinnitus isn't sexy enough. People are addicted to the chemical rush they experience when they get to pretend they're a good person by supporting a highly sympathetic figure such as an innocent child or a cute animal. The image of some cranky adults complaining about an 'imaginary' noise in their heads just doesn't get the juices flowing.
But the slogan "Support our troops" is well ingrained into the entire nation's heads after 17 years of the war on terror and tinnitus is the #1 service related disability. The image of a 22 year old that risked his life to fight for freedom getting disabled and tortured from this is something that needs to be promoted. Notice how you really NEVER see anything like what I just described.
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