Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
- Start date
I think it's for the same reason nerve pain fluctuates and that is... we don't know.
MemberStreet Novelist
Member
- Apr 2, 2018
- 293
- Tinnitus Since
- February 2018
- Cause of Tinnitus
- Listening to loud music through headphones
"Yes your WRS (Word Recognition Score) was not within the limit of what we are looking for, that is as specific as I can get with the disqualifying factor."
That's the e-mail I received in response as to why I was not accepted in the trial. I wish I knew what "within the limit" meant.
That's the e-mail I received in response as to why I was not accepted in the trial. I wish I knew what "within the limit" meant.
I bet that happens because micro blood vessels in the capillaries break down with age. With noise there is something called the glutamate storm.
No mystery. Your cochlea has a circadian clock. It is doing different things at different times of the day. This probably explains why so people get different types of damage, because of the time(s) of day it occurs.
I was thinking mitochondrial aging may have more to do with this but it's probably multi factorial.
I've said it before but it's pretty much proven it's in the brain. fMRIs have been done to show this. All the main researchers, the ones specifically targeting tinnitus, working on treatments are targeting the brain and have shown this reduces tinnitus (like Dr. Shore).
The brain makes it in response to damage in the cochlea. The hope is fixing that damage would also stop the brain's response of said damage (tinnitus).
The brain makes it in response to damage in the cochlea. The hope is fixing that damage would also stop the brain's response of said damage (tinnitus).
fMRI's are loud. If you're looking at the auditory cortex while undergoing fMRI, of course it's going to show activity, that doesn't mean that's where the sound is originating. The only way to see that would be to have a perfectly silent MRI machine and show that the auditory cortex is active and the auditory nerve is not.
Also, the tinnitus is in the brain hypothesis falls apart knowing that it goes away sometimes for some people and that OTO-313 showed reduction of tinnitus and that stuff gets nowhere near the brain, it goes into the cochlea, and stops the cochlea itself from being hyperactive. The cochlear fluids are separated from the brain by the BBB, the systemic blood flow, and the BLB. OTO-313 isn't restoring hair cells, or hearing function, it is an NMDA antagonist, acting on the NMDA receptors on the nerves in the cochlea, which means that the tinnitus signal, at least in many cases, originates in the cochlea.
But can't they compare it to a normal person's MRI? Yes, and they do.
And yet the doctor in charge of my OTO-313 trial knows that tinnitus is in the brain.
If any of you were to be accepted to phase 2 what reasons would you not do it??
If I do somehow get accepted I'm not sure I'd go forward with it with having a chance of making it worse or any long term side effects.
If I do somehow get accepted I'm not sure I'd go forward with it with having a chance of making it worse or any long term side effects.
A likely scenario is where we end up with a classification of subtypes of tinnitus. I do agree a large amount of patients will probably be helped with some sort of hearing restoration. That doesn't mean those patients will be cured with hearing restoration, but at least their tinnitus will be quietened.
That may or may not be true but fMRIs on the whole are much more problematic than most people realize:
http://blogs.discovermagazine.com/n.../fmri-gets-slap-in-the-face-with-a-dead-fish/
In a sense every bit of sensory information is "in the brain" in that it is perceived there. I think tinnitus is "in the brain" the same way a phantom limb. Whether or not you think hearing regeneration will work for this depends on whether you think hypothetically regrowing a limb would eliminate the phantom sensation. I personally think it would.
Calming down the neuro excitation seems another way to address this and that's certainly OTO-313's approach and I think Hough's (partially) too.
So then why is my tinnitus basically gone, right this instant? Because my cochlea is on the border between normal and malfunctioning and depending on my current status I can hear and then not hear and then my tinnitus comes back?
The tinnitus is in muh brain theory is based on something called the gating mechanism. They use that to say that the gating is broken and that's why some people have tinnitus and others don't that even have more hearing loss.
But if the gating mechanism thing is true, then how come some people get tinnitus immediately following acoustic shock? Because their gate is disrupted? Well then how come these some people don't get tinnitus every single time they are in silence? That doesn't make sense. Rauschecker is a goofball with tunnel vision. A better theory is that tinnitus is actually originating in the part of the auditory system before it reaches the brain.
Also, several of us get relief from curcumin. So is the curcumin adjusting the gating mechanism? Or is it reducing inflammation and possibly acting on BDNF levels in the auditory nerve? That makes more sense.
@Lucifer I'm gonna get the shot in less than two weeks.
Tinnitus being in the brain is not the gating theory. Rauschecker is a goofball, agreed there, his gating theory is massively flawed.
The research that looks very much undoubtedly true is the hyperactivity of fusiform cells in the dorsal cochlea nucleus, part of the brainstem. That's what Dr. Shore of the University of Michigan is targeting. That's how she has been able to quiet tinnitus in her ongoing trials built on over 15 years of research.
University of Arizona has actually recently found that tinnitus' root cause is that the cells in the auditory cortex are firing spontaneously (in line with Dr. Shore's research) because of inflammation in that region of the brain in response to acoustic trauma. They have found specifically, it is an abundance of the protein TNF-ALPHA and cytokines.
When people say brain, I automatically think of the auditory cortex. The brainstem makes more sense bexause it can be modulated by jaw movements. Im calling bullshit on the origins being in the auditory cortex.
If OTO-313 can quiet tinnitus then there's no chance that the patients it works in could have tinnitus originating in the auditory cortex or even the DCN because NONE of it would reach those areas via IT injection.
The auditory cortex research is newer, it could be that what is happening there is what causing it to happen in the brainstem. They were able to cure it mice by eliminating the inflammation, then verified it by inducing tinnitus in the mice by introducing the inflammation. It is still newer, but it's the cure if it works in humans. They are going to keep researching the pill's safety before trying it in humans.
It's awesome that you make that connection, that's actually a criteria Dr. Shore looks for in her trial. She calls it somatic tinnitus as not all people can do it. It's being able to change the tinnitus with body movements (like clenching your teeth or opening your jaw), she says this modulates the activity of the fusiform cells.
Not to be a Debby downer but I don't believe anybody "knows" anything about tinnitus's exact mechanism. If they did we could just target that specifically and be done with it.
I'm not a fan of the calming down neuro excitation method as it seems like a band-aid that will have to be re-administered continuously. I mean if it works "yay". BUT I'd much rather cure damage.
Again. All speculations. Nobody "knows" until we really truly know.
You're not downing me. I'll take Dr. Susan Shore's word over yours any day.
Have you even really looked into her research yet? You realize she's gotten people to silence right? Over 15 years of research to the point where she does have a mechanism to "target specifically"?
How exactly would inflammation in the auditory cortex cause the DCN to be inflammed?
Hey, if people are really getting silence now due to Lenire's bimodal stimulation treatment then that's news to me - and that's awesome. But I haven't seen too many glowing reviews of it here.
I believe that there are people out there that get it. There's really only a handful of prevailing theories. There is a Galileo out there somewhere.
Her device is the original, Lenire is basically a knock off by a private Irish start up company.
In fact when I emailed her about it, she seemed pretty skeptical of it. She warned of clinical trials lacking placebo control.
So you haven't seen the interview Tinnitus Talk has with her or her ATA podcast interview? She's one of the world's leading tinnitus researchers. Possibly the lead one, actually.
That's more of my theory, but I think it's the same principle in that the brain is very interconnected. I'm thinking these same inflammatory proteins are ending up in the DCN causing all the misfires, or if not it could be that the electrical misfires in the auditory cortex are also causing the misfires in the DCN. Ultimately, I think it is likely that it's all connected. Our biology always relies on its different parts working in unity, and problems in one area often cause problems in another.
For example, the newest Alzheimer's research shows that acting on one molecule specifically wasn't working, because there were still other molecules acting on the brain that were causing damage. This was done through a fMRI of people sleeping, where they found that Alzheimer's patients didn't have enough cerebral fluid coming in to "clean out" the harmful molecules in the brain that build up when awake. This explains how medicines targeting certain molecules wouldn't work, because the problem was bigger than just one molecule, there were other molecules still around doing damage. Ultimately, all of those molecules need to be washed out by cerebral fluid to treat the disease.
Here's the interesting read about cerebral fluid and sleep:
https://www.google.com/amp/s/www.wi...ow-how-sleep-cleans-toxins-from-the-brain/amp
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