Frequency Therapeutics — Hearing Loss Regeneration

Am I inventing the idea that we were going to get one of these guys on the Tinnitus Talk Podcast, or just one from Hough Ear Institute and Prof. Thanos Tzounopoulos? Either way, should be big time podcasts and I can barely wait for them.
Just Hough Ear Institute and Dr. Thanos.

No word from Frequency Therapeutics. I've heard @Markku and @Hazel have tried to contact them but they do not seem to want to get back to them.
 
It is becoming apparent that some people are seeking to destroy our rationally based optimism about this drug and hearing loss technology in general. Well, most of us are smart enough to think for ourselves and we aren't even being irrationally over-optimistic about this either, so these people can cry all they want.
Its possible some of the negative posters are working for and/or invest in the hearing aid industry and want this to fail.
 
Its possible some of the negative posters are working for and/or invest in the hearing aid industry and want this to fail.
My theory is that the very real idea of a cure, more specifically, the patient community's awareness of it, make these CBT shrinks mad because they don't even think we should even be made aware of such a thing because the best thing they can "offer" is habituation, and thinking about a cure delays the habituation process.
 
My theory is that the very real idea of a cure, more specifically, the patient community's awareness of it, make these CBT shrinks mad because they don't even think we should even be made aware of such a thing because the best thing they can "offer" is habituation, and thinking about a cure delays the habituation process.
Indeed, investing in CBT when it should be done on research and telling people "not to think" about their affliction is akin to claiming that bloodletting will heal tinnitus.

Unfortunately most tinnitus "experts" in the medical field are but crooks who make money off of our suffering.

If they have nothing to offer, they should just say so, instead of charging for visits and offering "relief" in the form of so called (palliative) "therapies". If you get stabbed, nobody sane will tell you to "just ignore the pain" and "learn to live with it", this is utterly ridiculous and the fact that we get advised this "course of treatment" and that this is "standard of care" in the 21st century is appalling at best.
 
Not saying it's not viable. I'm saying we have very little data to be super enthusiastic about. This drug did two things: 1. It increased 10 dB in 4 patients out of 15 that got it at 8000 Hz. 2. It roughly doubled the word scores of those patients. That's it. This has been discussed at length here. Not trying to be an asshole, but this is turning more into a thread where data is misinterpreted or exaggerated for therapeutic effect instead of discussing the research somewhat dispassionately and keeping us updated on the development of this drug.
I have to say that decreasing 10dB at 8000Hz, and likely more at uncharted frequencies, is actually fucking huge. I'm one of the fortunate people with a low frequency tone with which I can compare my high frequency electric hiss. I can tell you that if this drug only targeted the higher frequencies, I would shell out thousands upon thousands for relief from the high frequency. Much harder to mask, physiologically more anxiety inducing.
 
If restoring HF hearing loss treats HF tinnitus, then this very well may be more of a practical treatment for HF tinnitus over hearing loss, right?
 
Is there a thread or sticky with all the important dates, quarters in 2020 when we can expect trial results? Audion, Frequency Therapeutics, Dr. Shore, Otonomy, etc...
 
Is there a thread or sticky with all the important dates, quarters in 2020 when we can expect trial results? Audion, Frequency Therapeutics, Dr. Shore, Otonomy, etc...
This doesn't have a timeline, but I uploaded and attached a table I found with most of the currently known players. Inception is now Pipeline btw. Otologic Pharmaceutics I believe is the biotech partnering with Hough.
 

Attachments

  • 0_Schilder et al 2019 Otology NeurotologySupplementary table.xlsx
    25.8 KB · Views: 115
Not saying it's not viable. I'm saying we have very little data to be super enthusiastic about. This drug did two things: 1. It increased 10 dB in 4 patients out of 15 that got it at 8000 Hz. 2. It roughly doubled the word scores of those patients. That's it. This has been discussed at length here. Not trying to be an asshole, but this is turning more into a thread where data is misinterpreted or exaggerated for therapeutic effect instead of discussing the research somewhat dispassionately and keeping us updated on the development of this drug.
It's actually pretty impressive given the very low dose administered during the trial.
 
Earlier in this thread someone said one of the founders of Audion had expressed caution when it came to both Regain and FX-322, however, I can't find that now (I can find the post if I search for "regain sobering" but I can't find what the founder supposedly said). What was the story behind this? Did they want to keep people from getting too excited?
 
I was just thinking about something that may have been covered, but I can't commit myself to 194 pages of back-checking.

What happens to the dead hair cells? Are they not subject to macrophages or other cellular waste removal systems? Would this be an important pre-treatment therapy, as to erase the brains familiarity with its old pathways?
 
Earlier in this thread someone said one of the founders of Audion had expressed caution when it came to both Regain and FX-322, however, I can't find that now (I can find the post if I search for "regain sobering" but I can't find what the founder supposedly said). What was the story behind this? Did they want to keep people from getting too excited?
Audion/Regain is the same company.
 
If restoring HF hearing loss treats HF tinnitus, then this very well may be more of a practical treatment for HF tinnitus over hearing loss, right?
Just from guessing I'd say most of the high frequencies are the first to go as well as the easiest to lose. The fact that tinnitus is usually a high pitched tone is suggestive of this also. Brain is lacking input from these frequencies and making it up. People with multi tonal tinnitus suggests damage on a larger range of frequencies both low and high. The fact that it's permanent non-stop also suggests brain senses input at all times even though we don't realise it. So as much as 12 kHz+ is pretty much irrelevant for hearing.

Telling someone who goes for a standard hearing test that their hearing is perfect is laughable at best. It's literally half a frigging test.
 
Just from guessing I'd say most of the high frequencies are the first to go as well as the easiest to lose
It makes great sense because HF waves carry the most energy at the same amplitudes as other waves and the HF part of the cochlea is the nearest to the oval window where the stirrup bone that transfers the sound from the anvil and hammer connects.
 
Earlier in this thread someone said one of the founders of Audion had expressed caution when it came to both Regain and FX-322, however, I can't find that now (I can find the post if I search for "regain sobering" but I can't find what the founder supposedly said). What was the story behind this? Did they want to keep people from getting too excited?
Sounds like something I posted. The guy didn't mention any company by name. He was sounding a general note of caution I guess. Wait for the science to be proven before you get people's hopes up is what he was saying.
 
Sounds like something I posted. The guy didn't mention any company by name. He was sounding a general note of caution I guess. Wait for the science to be proven before you get people's hopes up is what he was saying.
Wasn't he asked about Regain when he answered that though?
 
Sounds like something I posted. The guy didn't mention any company by name. He was sounding a general note of caution I guess. Wait for the science to be proven before you get people's hopes up is what he was saying.
I think the pessimistic tone of that comment was derived from this not being a 100% cure for hearing loss. Tinnitus patients are going to be like puppies getting scraps off the table, which is fine with me.
 
Wasn't he asked about Regain when he answered that though?
He was talking about Regain but I think the line about not getting people's hope up was meant as a good guideline for scientists to follow. My memory's not clear on this. No idea how to find the article.
 
Another day, another signalling pathway. This may be worth a topic on its own. I wish someone with knowledge could compare and contrast with Frequency Therapeutics. Chen and the Frequency Therapeutics honchos all work for the same institutions. Different labs, same university affiliations. Chen seems to be claiming that his study is the first to achieve hair cell regeneration. Really? Anyway, for what it's worth...

https://www.news-medical.net/news/2...er-to-developing-hearing-loss-treatments.aspx
 
Another day, another signalling pathway. This may be worth a topic on its own. I wish someone with knowledge could compare and contrast with Frequency Therapeutics. Chen and the Frequency Therapeutics honchos all work for the same institutions. Different labs, same university affiliations. Chen seems to be claiming that his study is the first to achieve hair cell regeneration. Really? Anyway, for what it's worth...

https://www.news-medical.net/news/2...er-to-developing-hearing-loss-treatments.aspx
My guess is "reprogram using transcription factors" is different enough to the progenitor cell activation that Frequency Therapeutics does to claim to be the first.
 
Another day, another signalling pathway. This may be worth a topic on its own. I wish someone with knowledge could compare and contrast with Frequency Therapeutics. Chen and the Frequency Therapeutics honchos all work for the same institutions. Different labs, same university affiliations. Chen seems to be claiming that his study is the first to achieve hair cell regeneration. Really? Anyway, for what it's worth...

https://www.news-medical.net/news/2...er-to-developing-hearing-loss-treatments.aspx
Wth they don't even tell you what the title of the paper is.

Renewed proliferation in adult mouse cochlea and regeneration of hair cells
 
Another interesting aspect of this paper is he seems to be using a new model where they grow cochlear cells in a "bony incasing" to mimic in vivo testing. Seems like this could accelerate pre-clinical studies if widely used.
 

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