Frequency Therapeutics — Hearing Loss Regeneration

#603
So it looks like they are going to try it on people that are already going to get cochlear implants. This confirms what I have been saying all along, which is that they aren't going to risk someone with moderate hearing loss on the first trials to see what happens. This is probably just to test the safety in humans since 80db loss at 500 hz or worst is what they are looking at. It would be great to see if some of these people actually benefited from the procedure as well and that no adverse affects are recorded since it has been mentioned that they will ultimately help someone with moderate hearing loss.

I bet if this is successful, the trials will include people with moderate hearing loss as well, which is what some people were speculating.
 
#604
RB2014 said:
So it looks like they are going to try it on people that are already going to get cochlear implants. This confirms what I have been saying all along, which is that they aren't going to risk someone with moderate hearing loss on the first trials to see what happens. This is probably just to test the safety in humans since 80db loss at 500 hz or worst is what they are looking at. It would be great to see if some of these people actually benefited from the procedure as well and that no adverse affects are recorded since it has been mentioned that they will ultimately help someone with moderate hearing loss.

I bet if this is successful, the trials will include people with moderate hearing loss as well, which is what some people were speculating.
Click to expand...

That's not the point of the trial they are conducting in Australia. Again, please read the last few pages.
 
#605
acufenero said:
That's not the point of the trial they are conducting in Australia. Again, please read the last few pages.
Click to expand...

Thanks, I read the last few pages. It is a safety study to see what happens to humans when this is injected into their middle ear. I guess I missed the part where it happens right before cochlear implant surgery, so there is no way to know if there will be any benefits.

I'm not really sure who will agree to do this. If I'm reading it right there are no benefits to the patient, but the possibility of adverse affects.
 
#606
RB2014 said:
I read the last few pages. It is a safety study to see what happens to humans when this is injected into their middle ear. That's what my post said. If I missed something let me know.
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I think it is to determine the concentration of their compound within the cochlea fluids at different time spans. This, I guess, to determine what dosage they will have to inject come phase 1!
 
#607
RB2014 said:
Thanks, I read the last few pages. It is a safety study to see what happens to humans when this is injected into their middle ear. I guess I missed the part where it happens right before cochlear implant surgery, so there is no way to know if there will be any benefits.

I'm not really sure who will agree to do this. If I'm reading it right there are no benefits to the patient, but the possibility of adverse affects.
Click to expand...
There will of course be a nice financial reward for the participant
 
#609
Amber said:
The financial rewards are usually about $200 to 500... not a lot
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I think it highly depends on the study. Ive seen rewards in the range of 5.000 dollars for studies here in Belgium. It's an easy way to get a high income if you want to risk your health at the same time.
 
#610
Granted this works! When would most people want to try this? My choice is phase III....if it works.
 
#614
Its a pity that they are going through cochlear placement surgery but if the goal is to measure the drug concentration in the cochlea i guess its the only way to do it, still even in this case i would like to know if it has any effect and i still hope that the patients are gonna gain something from the procedure

https://www.hindawi.com/journals/ijoto/2014/468515/
In this case, where patients with severe and profound low frequency loss are recruited we could see some more interesting results beyond concentration of the drug
 
#615
Forgive the ignorance, but how does this help moderate hearing loss/T patients if no cochlear implant is necessary? Won't an implant given to someone with moderate hearing loss make the hearing worse?
 
#616
Spiral said:
how does this help moderate hearing loss/T
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This procedure is an investigative test to determine the amount of the drug that makes it into the ear and blood stream. Frequency is only marrying its drug with a CI procedure because it allows them to more easily sample the fluid in the cochlea.
 
#618
Participants must be adult and audiometric threshold of 80 decibel [dB] hearing loss [HL] or poorer at 500 Hertz [Hz]

This is way beyond moderate hearing loss and participants are already scheduled for CI placement
 
#619
Makes sense to use CI patients. There can be little damage done to the cochlea/hearing cells, and you can test the effectiveness of the drug reaching the desired place. Really curious for the results of Frequency, their current results and prognosis almost sounds to be good to be true. If it works, they deserve a Nobel price, though the guinny pig patients deserve a medal as well. If I were them I would be asking for shares in the company for compensation.
 
#621
Jim51042 said:
I really think people should not expect frequency to eliminate ear pain in the presence of sounds (for those who have it). If the theory of hyperacusis is true that sound interacting with damaged nerve fibers create a pain signal then Frequency's add on a strategy likely won't reduce the pain. If your pain is not due to external sound but from the vibrating of your head then Frequency might work. A hyperacusis fix maybe more likely to come from a company targeting existing nerve fibers... say Spiral or Affichem
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I am just speculating on the mechanism here, but for people with H that comes on after T (or simultaneously with T), my best guess is that the "gain" knob in your auditory cortex is turned WAY up, and T is our "noise floor". H comes along because of the high gain setting. If you give the auditory cortex proper input again (fixing damaged cilia), the gain "should" be lowered, lowering the noise floor and mitigating H. That is my best guess anyway.
 
#622
MidnightOilAudio said:
I am just speculating on the mechanism here, but for people with H that comes on after T (or simultaneously with T), my best guess is that the "gain" knob in your auditory cortex is turned WAY up, and T is our "noise floor". H comes along because of the high gain setting. If you give the auditory cortex proper input again (fixing damaged cilia), the gain "should" be lowered, lowering the noise floor and mitigating H. That is my best guess anyway.
Click to expand...
I agree. Took me about a year, after getting T, until H developed as a consequence. When I rattle a box of pills near my left and right ear, the volume perceived is totally different in my damaged ear. So I really "buy" into that gain knob thing. Fix the input recipients, brain lowers the gain, T and H solved:cat:
I beg this to be true!
My biggest fear is not wether their compound will work or not, activating dormant cells, but a depletion of my progenitor cells.
 
#623
grate_biff said:
I agree. Took me about a year, after getting T, until H developed as a consequence. When I rattle a box of pills near my left and right ear, the volume perceived is totally different in my damaged ear. So I really "buy" into that gain knob thing. Fix the input recipients, brain lowers the gain, T and H solved:cat:
I beg this to be true!
My biggest fear is not wether their compound will work or not, activating dormant cells, but a depletion of my progenitor cells.
Click to expand...

I don't have H in the way people here describe it (no actual pain), but about 4 or 5 months after the onset of my T, I got TTTS. So loud "startle" noises cause a physical thump in my ears that I can hear and feel. Again, no pain, the thump is akin to a muscle twitch feeling.

I really feel for people with terrible H, that is something I wouldn't wish on anyone. T is bad enough.
 
#624
MidnightOilAudio said:
I don't have H in the way people here describe it (no actual pain), but about 4 or 5 months after the onset of my T, I got TTTS. So loud "startle" noises cause a physical thump in my ears that I can hear and feel. Again, no pain, the thump is akin to a muscle twitch feeling.

I really feel for people with terrible H, that is something I wouldn't wish on anyone. T is bad enough.
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It is so weird met a guy was drummer has hearing loss NIHL says can't hear tinnitus and NO H!!! WTF he has more damage then me and my T sucks!!! Thank god for no H!!! Truely sucks but as they say "help is on the way!"
 
#625
grate_biff said:
Personally, I believe that our HC, to some degree, actually has the ability to regenerate by themselves(contrary to science, I know). I have had some traumas over the years, where T would generate, staying for a few months, and then slowly vanish again. To me that is not good news according to the treatment FTX has to offer as I may be depleted of my dormant/progenitor cells already.
Click to expand...
Was reading back in the topic, and came across below message of grate_biff. This is also partly my concern but reading below:
src: http://www.frequencytx.com/news-events/pr-02-21-2017.php
With the combination of a GSK3 inhibitor to activate the Wnt signaling pathway and a histone deacetylase (HDAC) inhibitor to activate gene transcription, the research team achieved >2000-fold expansion of cochlear supporting cells compared to previous approaches.
Click to expand...

I would almost assume, even if you would have one left, they would be able to generate 2000 new one right? Perhaps you need a second round of injection, and based on the multiplier above, you should then still be safe, given it works that way. Anyways, I found it to be reassuring the were able to generate such an expansion. Only thing I can't find if their targeting OHC, IHC or both?

Wish I had a crystal ball.
 
#626
Berik said:
Was reading back in the topic, and came across below message of grate_biff. This is also partly my concern but reading below:
src: http://www.frequencytx.com/news-events/pr-02-21-2017.php


I would almost assume, even if you would have one left, they would be able to generate 2000 new one right? Perhaps you need a second round of injection, and based on the multiplier above, you should then still be safe, given it works that way. Anyways, I found it to be reassuring the were able to generate such an expansion. Only thing I can't find if their targeting OHC, IHC or both?

Wish I had a crystal ball.
Click to expand...


In an article they said in young animals they got great data! In mature animals not so much I hope the figure out why that is and fix it! Please help us!!!
 

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