Member- Apr 15, 2017
- 1,419
- Tinnitus Since
- 2008
- Cause of Tinnitus
- Noise
Once the hair cells are damaged they tend to die, frequencies approach won't repair those damaged cells but create new ones
Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
- Start date
Once the hair cells are damaged they tend to die, frequencies approach won't repair those damaged cells but create new ones
They die? Well even after a year they seem alive and well because they're fucking ringing like crazy still to this day haha. I just understand how this works.... like the hair cells will repsond to sound regardless of if you want them to or not, like the sound waves will still hit those defective/damaged hair stereocilia regardless if there are new ones next to them? I want to see something that actually REPAIRS the damaged ones we have...not make new ones.
Are we/frequency just assuming that that the new cells will take over the dead ones which will cause them not to respond to sound stimulus ?
I think this may be a misconception about how hair cell damage causes tinnitus. It's likely that the brain amplifies frequency bands where there is reduced signal, i.e dead hair cells/synapses/neurons. So your perception of ringing is not necessarily evidence that hair cells are "alive and well"
sorry i was a little unclear, I am meaning that those dead hair cells are still making noise/brain stimulus is filling the gaps of missing frequencies. Their approach is creating new hair cells, but the old ones are still going to be there. Won't the dead ones still be firing away regardless of the new hair cells that have been made? Or do you think the dead hair cells will think "ah! there are new hair cells next to me now, i guess I can turn off now" and you'll see the new hair cells become fully functioning without the dead ones doing anything?
As far as I understand it, the dead cells are cleared away/reabsorbed by the body and are no longer present at all, so regenerated hair cells will be in their place not "next to" dead cells.
https://www.google.co.uk/imgres?img...KDYAhUsCMAKHZYpCF0QMwhBKAIwAg&iact=mrc&uact=8
I contacted Frequency terapeutics with the question of whether their methods in the future would be effective for other types of damage to the inner ear - ototoxicity, etc. But he did not receive a reply. I wrote them to the email addresses listed on their official website, as well as to Twitter. I do not understand why all the articles speak only of noise-induced hearing loss? That their focus is just this. After all, the mechanism of damage is similar and with ototoxicity - damage to hair cells. Do you have any other addresses that you can contact representatives of frequency terapeutics?
https://www.businesswire.com/news/h...s’-First-in-Human-Safety-Study-FX-322-Hearing
https://www.businesswire.com/news/h...s’-First-in-Human-Safety-Study-FX-322-Hearing
Rubenslash
Member
Lol, do you really think is already known while they are only in early stage clinical trials?
I guess that there is not a straightforward answer because it depends on the toxin. Some drugs may destroy just the hair cells, in which case FX-322 will (theoretically) work, some may destroy supporting cells as well, in which case FX-322 will have no effect.
I assumed something
When I do that and I got it wrong I always remember this quote from Steven Seagal in one of his movies.
"Assumption is the mother of all %$#$-ups".
I am sure this is a general quote and he did not invent it.
I am surprised though that this brain plasticity can act so quick.
Or: to assume makes an "ass" out of "u" and "me"I assumed something
When I do that and I got it wrong I always remember this quote from Steven Seagal in one of his movies.
"Assumption is the mother of all %$#$-ups".
I am sure this is a general quote and he did not invent it.
- Apr 15, 2017
- 1,419
- Tinnitus Since
- 2008
- Cause of Tinnitus
- Noise
When laser eye surgery came out, it was thousands (I imagine around £20,000), now it can be done from a few hundred pound.
The usual business sense is that it will start of at a high price, to sell those who are prepared to spend too whack for it and when that market is closing they reduce the price to get the next bunch of people in - just like for example the PlayStation. They sell it for £350, then £300 then £200 then £150 and so on.
If they fix my hair cell I would start treating my ears like it's the most precious thing in the world
Hopefully you could just do the treatment again... Although knowing what we know now I doubt any of us would put ourselves in positions to damage ourselves again. I've done some really stupid things to my hearing, would never dream of doing them again.
My first bet would be that it can be done again, it doesn't get rid of your supporting cells.
I already did before my hearing damage.
Unfortunately someone else could be "doing" it for you.
This is how I ended up in this situation.
I suppose (I don't want to use assume any-more
) it all depends on what happens after activating the progenitor cells. FT mentions that they want to activate the progenitor cells and let (hopes) nature take(s) over. I am sure this is a very simplistic depiction of the whole process. Will this process than be similar to what happens in (for example) birds?
If so, I could understand you can repeat this treatment.
- Apr 15, 2017
- 1,419
- Tinnitus Since
- 2008
- Cause of Tinnitus
- Noise
I don't know about anyone else but the main problem if this out for me would be that there is no diagnositic test to see even if I have cochlear damage/lost cells as my hearing test showed normal even though I have tinnitus. Well at least 250-8khz test shows normal.
Same, my hearing is fine in 250-8k are but I recently lost feel for bass and I can't hear very high frequencies but that's not measured on audiograms.
A little bit of Therapeutics to regenerate hair cells and a bit of af243 to regenerate damaged nerves. And surely we will improve a lot ! Merry Christmaa
My audiogram is normal. However if I do a test in my closet using the tonegen app on my phone I find there is distortion at very low volumes at frequencies below my T. I can still hear stuff there but the tones sound very off until I hit a certain volume. I don't think the std hearing tests pick this stuff up because you still hear sound. It might not be correct, but you do hear something. I'd be willing to bet a lot of people with noise induced T, but "normal" audiogram, have a notch in their audiogram and the test is just too coarse to reveal it.
I would encourage you to try the tonegen app and see what you find. You have to use the lowest volume and sometimes move the phone further away from you to get to the lowest volume. Holding an earbud in your hand away from your ear will work too. Start with a tone a hundred to two hundred hertz below your T frequency. Just have to be in a very quiet room. No fans or HVAC can be running. Closets are best.
as long it does goes in the same direction like Spark Therapeutics, who has a new therapy for blindness with cost of 1 Milion Dollar.
https://www.ft.com/content/f98a354a-e50a-11e7-97e2-916d4fbac0da
Funnily enough, I am monocular but I wouldn't want to fix that lol, and not for that price.
Hope they make it to a final product. Phase 2 has a success rate of 18%, phase 3 50%. So approximately 9% chance. Well, lets hope it works out.
Opening this direct link doesn't work if you don't have a Financial Times subscription, they have paywalled their shit.
SOLUTION:
>Do a Google search for "Price of world's first potential $1m drug under scrutiny"
>Click on the first search result to open the article
>Profit
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