Frequency Therapeutics — Hearing Loss Regeneration

#1,501
CricketEars said:
That sucks for those of use who have higher frequency loss, especially when the ENT's say hearing aids won't help. But maybe they are looking to do something specific and if it is successful, they will branch out to other types of hearing loss
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The normie's hearing loss
4khz drop on the audiogram

The mentally ill perosn's hearing loss
6-14khz muffling doesn't show up on the audiogram until 10k, no one cares about frequencies above 8k.
6k hearing loss is hidden so who cares about my suffering lol
 
#1,504
Onebigburb said:
Speculation at this point is only that. They (and us) simply need people willing to try it. So instead of that lets focus on getting people aware of it. So they can hopefully get into trial. I know I was willing to fly there. This could be a problem for many people. A funding account or something to help people who want to but cant affoard to would be the best thing, I think any of us could do an promoting awareness.
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I'm ready to go lol. Don't really have the money to fly from Maryland to Texas though. I have a 50db loss at 4000hz in my right ear and maybe 10db loss at 4k in my left. Do you think that's good enough to get in? I'm also 29 and very healthy otherwise. Had recent blood work done at the doctor and I'm literally perfect blood work wise. Any hear sugar daddy's out there wanna fund my trip lol
 
#1,506
Pero1234 said:
If there's money to make, we'll be able to get it, no doubt! Even if we only suffer from high frequency loss.

But all costs will be ours. Health insurance will not cover it for (high frequency-related) tinnitus only.
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So do you think they will cover it for hearing loss starting at 4k with a loss of 50dbs?
 
#1,507
JohnAdams said:
I may be. I can still function normally in my life, and I'm not angry or violent, that's all that matters to me. Really though, who isn't insane?
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I'm insane for sure. Tinnitus didn't help there at all lol. Really don't like the ringing though. Happy that it could be gone soon and it's likely not life long
 
#1,509
Contrast said:
Make sure they test it on people with hidden hearing loss such as myself.

Inject FX-322 in my right ear please, i'd love to be able to hear sharp high pitched notes again normally instead of them muffling. My cochlea will thank you
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d'Wooluf said:
Hmmmm. I wouldn't believe what the receptionist says. And if the ent's are casually passing on information like that, it's strictly amateur hour. Also, they are testing a hearing loss treatment, not a treatment for tinnitus. They are going to be selecting participants with common types of hearing loss. Easy to measure and easy to compare against large populations.
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We are all assuming, hoping that T and hearing loss are related.
 
#1,513
Got this fortune cookie yesterday.
 

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#1,514
I get that. The thing is, if you're designing a trial, you try to rule out as many complicating factors as possible to maximise your chances of proving a simple cause and effect. I think tinnitus would be a complicating factor. The Regain Project trials in Europe explicitly excluded participants who suffered from tinnitus where the tinnitus was a bigger problem to them than hearing loss. It doesn't mean that fx-322 won't benefit tinnitus sufferers if it's successful.
 
#1,515
Does anyone know how they are activating the progenitor cells? Some kind of virus perhaps? There are body fluids in the ear that obviously are derived from the circulatory system so what if the answer is to just find out the substance or virus or bacteria or whatever that triggers proginitor cell growth and eat high doses of it for a few days until your body is saturated and its secretes in the inner ear fluid? Who knows? What if the answer is to drink a huge newt smoothie 3 times a day?
 
#1,516
JohnAdams said:
Got this fortune cookie yesterday.
Click to expand...

I get that.

When my body was giving me signals, I did some meditation and carried on. I stayed as restless and gloomy as before...

Now it was like my body / mind smacked me to the ground with tinnitus and said: "... and stay down!! Listen to me!"

Let's all hope we get another shot at peace and quiet in the next 5 years. I'll make sure I live my life so I deserve it... but all we can do is wait and see.
 
#1,517
Deathtotinni said:
I'm ready to go lol. Don't really have the money to fly from Maryland to Texas though. I have a 50db loss at 4000hz in my right ear and maybe 10db loss at 4k in my left. Do you think that's good enough to get in? I'm also 29 and very healthy otherwise. Had recent blood work done at the doctor and I'm literally perfect blood work wise. Any hear sugar daddy's out there wanna fund my trip lol
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I will say this any one who is able to get in who can prove they are in an cannot affoard the flight an they "frequency" will not pay for it. I will gladly help out as I can.
Flamingo1 said:
is there a way to invest in this company?
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If my memory serves me right on thier site you can donate.

Again if no one does the trial then no one knows the answer. Since mine is unilateral. I would do it. I have said since the beginning of this. I WOULD RATHER THEM CUT THE WIRES IN THAT EAR AN MAKE IT COMPLETLY DEAF! I would risk it simply for better of man kind. If that ear was gone completely I would stop thinking about it an move on. If they stop making your favorite soda, you get upset. Eventually you know its gone an so you move on. It becomes a wonderful afterthought. "Those were the days" so to speak. Thats my .02cents.
 
#1,518
JohnAdams said:
Does anyone know how they are activating the progenitor cells? Some kind of virus perhaps? There are body fluids in the ear that obviously are derived from the circulatory system so what if the answer is to just find out the substance or virus or bacteria or whatever that triggers proginitor cell growth and eat high doses of it for a few days until your body is saturated and its secretes in the inner ear fluid? Who knows? What if the answer is to drink a huge newt smoothie 3 times a day?
Click to expand...

"Small molecules". I don't think anything taken orally is going to make it to your inner ear in big enough quantities. Injecting your newt smoothie through your eardrum on your own might be... challenging. :)
 
#1,519
d'Wooluf said:
"Small molecules". I don't think anything taken orally is going to make it to your inner ear in big enough quantities. Injecting your newt smoothie through your eardrum on your own might be... challenging. :)
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My thinking is that inner ear fluid comes from blood and isnt inside the blood brain barrier, therefore if you took something in high quantities that it would have to be present in all fluids. Im not a molecular biologist so I dont know that for a fact.
 
#1,522
d'Wooluf said:
"But the ear is what's called a privileged compartment; it has spaces in it where the liquids are cut off from any other liquids in the body. "

Quoted from https://www.scientificamerican.com/article/theres-an-inverse-piano-in-your-head/
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From phase 1 trial:
"Further, the results validated the feasibility of using a standard intratympanic injection to deliver FX-322 locally to the inner ear. In addition, we found that FX-322 successfully diffused from the middle ear to the perilymph fluid in the cochlea with minimal systemic drug exposure."

https://www.businesswire.com/news/h...s’-First-in-Human-Safety-Study-FX-322-Hearing

Tempanic membrane is your eardrum. Intra-tympanic means through the ear drum.
 
#1,526
My belief is that, if Fx-322 works, that they will get through phase 2 by the end of the year, or early next year and if they are successful then the inertia will increase, and by inertia I mean money, and then phase 3 should begin and conclude sometime by the end of 2019. If word starts getting out that they can cure hearing loss then more people will be making videos and news articles about it and the more this gets out the faster then the likelier that this will get FAST TRACKED.

https://www.fda.gov/ForPatients/Approvals/Fast/ucm405399.htm

Fx-322 is not like other drugs, if it works, this will be the closest thing to a miracle than mankind has ever achieved on his own. Just imagine if more people were aware of this.
 
#1,527
JohnAdams said:
My belief is that, if Fx-322 works, that they will get through phase 2 by the end of the year, or early next year and if they are successful then the inertia will increase, and by inertia I mean money, and then phase 3 should begin and conclude sometime by the end of 2019. If word starts getting out that they can cure hearing loss then more people will be making videos and news articles about it and the more this gets out the faster then the likelier that this will get FAST TRACKED.

https://www.fda.gov/ForPatients/Approvals/Fast/ucm405399.htm

Fx-322 is not like other drugs, if it works, this will be the closest thing to a miracle than mankind has ever achieved on his own. Just imagine if more people were aware of this.
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hearing aids and tinnitus retraining therapy are already considered treatment options so there's no hope on a fast track
as they consider dancing around the symptoms just as importance as fixing the actual problem.
 
#1,528
Contrast said:
hearing aids and tinnitus retraining therapy are already considered treatment options so there's no hope on a fast track
as they consider dancing around the symptoms just as importance as fixing the actual problem.
Click to expand...

But the primary goal is to restore hearing loss, which is big shit. T is just a secondary consequence of hearing loss. We will ride on the coattails of this technology to a cure. I think when public awareness of this increases, so will the rate at which they get it to us. This isn't just a new drug, this is an entirely new world of medical technology that may even lead to cures for many other conditions, like paralysis, heart disease, amputations, etc.

For those of us with manageable T that can still work and be involved with our families, we are somewhat lucky to have T now that we have it because we may actually be cured somewhat soon and when we do, we will have built great emotional adversity. I've been reading the published scientific papers about this technology and it's there. We just have to be patient and wait for it to hit the market. I firmly believe that. The only thing that could cause a delay would be an apocalyptic war scenario accompanied by a global depression and hopefully that doesn't happen.

"the fact that this was an in vivo study that restored hearing in mice shows the promise of this approach for hearing restoration in humans."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534485/

they have restored hearing in mammals. IN VIVO means in a living organism, not just some dead cochleas in a pitri dish.

That's VERY AMAZING. I know it's hard to live this way and it is easy to lose hope. But just wait. I think we will be okay. And if anything, if the Susan Shore device get's released, at least we can have a better life, just attached to a machine for half an hour a day.
 

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