Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
- Start date
Member
Street Novelist
Member
- Apr 2, 2018
- 290
- Tinnitus Since
- February 2018
- Cause of Tinnitus
- Listening to loud music through headphones
So, people think pushing back-to-back dosages at the same time is overkill? Any scientific evidence for that? If they did 1 dose per month, would that work better?
This reads like massive denial. Buying more shares is straight up reckless. It's your money so do what you want with it of course. Just feels like someone needs to say that doubling down on an investment when the company has completely dropped the ball and the price has plummeted is very high-risk and low reward.
I don't want insult added to injury and inexperienced, emotional investors reading this thread and thinking that's a good idea. It's not. I'm seeing sunk cost fallacy all over the place, everyone is fine with losing it all rather than getting out with at least some money and living to fight another day. That's not rational. The rational move is to cut losses immediately and wait for good news to justify re-investing. And if it keeps bleeding down after you sell, you can decide whether you want to buy back in at a lower price.
Coleoptere
Member
I still assume FX-322 works (at least in single dose). It looks like they need some more experimenting. Dose, interval, method of delivery. Unfortunately that is hardly possible under the FDA system and of course available budget.
Please tell me what I want to know the most.
Did Phase2a improve anyone's dB of EHF?
Didn't they say "there was no improvement in this cohort as a whole"?
Didn't even one person improve the dB of EHF at all in Phase1b FX-322-111? Or did they say that "the subjects as a whole did not improve"?
In both cases, if no one has improved at all, Phase 1/2's 10 dB (8 kHz) and 5 dB (6 kHz) will be fluke, mistake, and meaningless.
The credibility of hair cell regeneration becomes questionable.
I don't know how it was expressed, so please let me know.
Did Phase2a improve anyone's dB of EHF?
Didn't they say "there was no improvement in this cohort as a whole"?
Didn't even one person improve the dB of EHF at all in Phase1b FX-322-111? Or did they say that "the subjects as a whole did not improve"?
In both cases, if no one has improved at all, Phase 1/2's 10 dB (8 kHz) and 5 dB (6 kHz) will be fluke, mistake, and meaningless.
The credibility of hair cell regeneration becomes questionable.
I don't know how it was expressed, so please let me know.
Frequency Therapeutics will eventually zero in on successfully treating sensorineural hearing loss, it is only a matter of time. It is back to the drawing board to unlock the answers we need, the signal is there.
paul mclean
Member
- Sep 8, 2020
- 77
- Tinnitus Since
- 2018
- Cause of Tinnitus
- falling asleep with headphones in on loud
I still don't understand how WR scores can increase in all groups but it "didn't work".
Does anyone know if they have to do Phase 1/2 again to change it from 4 doses to one?
Or do they just have to do Phase 2 again?
Or best case scenario is FDA allow them to go straight to Phase 3 because of the other studies they've done.
Does anyone know if they have to do Phase 1/2 again to change it from 4 doses to one?
Or do they just have to do Phase 2 again?
Or best case scenario is FDA allow them to go straight to Phase 3 because of the other studies they've done.
- May 27, 2020
- 556
- Tinnitus Since
- 2007
- Cause of Tinnitus
- Loud music/headphones/concerts - Hyperacusis from motorbike
I'm confused. How would they know they only got two doses of FX-322 if everyone, including patients, is still blinded at the individual level? You even then say it was an unknown amount.
I've just woken up and all I feel about this process is complete and utter anger because I've realised there's only one of two possibilities: either this drug doesn't do anything in humans and we've all been misled, or a bunch of selfish, desperate people have knowingly lied to get into the trial and potentially ruined the one and only chance for the rest of us to rebuild our lives. I am livid. If you are one those patients and happen to be lurking this forum, I only have two words for you. No prizes for guessing what those words might be.
I'll admit I know next to nothing about those devices. But isn't she taking a very long time?
Thank you! Otonomy is doing their 3rd or something Otividex trial and still haven't given up. People act like failing a clinical trial means that they're just going to accept defeat and go home.
Thousands of successful drugs have failed clinical trials.
No way have we been misled. The data was reviewed by third parties AND the FDA. Besides, there's the fact that several scientific A listers are on the Frequency Therapeutics Team; they wouldn't ruin their reputations to make a quick buck.
She's been taking her sweet time, but barring another pandemic, their current Phase 2 trial should conclude this year with results out middle of next year. Medical devices only need to go through a feasibility and pivotal trial before applying for FDA approval so presumably if the results from this trial are good, they'll seek FDA approval after this.
- Feb 20, 2021
- 51
- Tinnitus Since
- 10/2019 (mild), 09/2020 (severe)
- Cause of Tinnitus
- SSHL
The whole situation stills feels so unreal. I also still cannot get over the fact how FREQ acted so positively over the last weeks and the results have been so bad. Do we have a guess since when have they had the data on their desk? It' s just crazy that they released the paper for Phase 1 with the good results, made new top tier hires for the company and posted many positive tweets while the might have known already that things are bad.
Another question which I asked myself today: So you cannot just sell shares as an insider whenever you want. You have to submit your stock trades a long time in advance. But this does not mean that you cannot still optimise profit. The date of sale/buy is fixed, but if you can choose to release the trial results before or after you sold your stock while knowing what the impact of the results will be on the stock market, this gives some strong reasons to choose wisely when to make the results public...
Another question which I asked myself today: So you cannot just sell shares as an insider whenever you want. You have to submit your stock trades a long time in advance. But this does not mean that you cannot still optimise profit. The date of sale/buy is fixed, but if you can choose to release the trial results before or after you sold your stock while knowing what the impact of the results will be on the stock market, this gives some strong reasons to choose wisely when to make the results public...
Don't give your hopes up. We've seen it in the Phase 1/2 trial, the drug IS working. Maybe just multi-dosing wasn't the right approach. I think there's no one who does his homework right the first time.
5 years ago, we weren't even near to a possible solution. Now there are a lot of companies that want to treat hearing loss. We are very close to something that would help us. It's just a matter of time. Keep on fighting!
5 years ago, we weren't even near to a possible solution. Now there are a lot of companies that want to treat hearing loss. We are very close to something that would help us. It's just a matter of time. Keep on fighting!
Someone literally said yesterday in the investor conference that the weekly injection was "too much, too soon."
Their Phase 1 was encouraging enough for them to pursue a Phase 2. This doesn't detail out the exact data from the trial but does provide a pretty good overview.
In First Test, Specially Timed Signals Ease Tinnitus Symptoms
Let's say FREQ goes under (which I don't think will happen), someone will buy the PCA system. There's a myriad of hedge funds and venture capitalists ready to drop millions on this, it's going to be a multi billion dollar business.
The answer is no: not one person in their Phase 2a improved on the audiogram, including extended high frequencies. Furthermore, they apparently ran a parallel new Phase 1/2 trial. Again, not one patient improved on the audiogram, including extended high frequencies. Listen to their webcast from yesterday, last few minutes.
Since weekly FX-322 doses were too much, do you think fortnightly or monthly doses is a better long term solution with the current delivery method?
Is fortnightly still too frequent to be injected with FX-322?
Is fortnightly still too frequent to be injected with FX-322?
I really don't see this happening. Single dose has been more effective with FX-322. It's just how to get FX-322 deeper in the round window whether that is by reformulating or additional doses monthly.
We keep praying and praying but today I came to the conclusion that God has hearing loss himself.
Weed out the fucking liars and inject once every 3 weeks or something. I think they have a real shot a getting this one to market and then FX-322 V 2.0 will be reformulated.
This is a moot point now anyway, they'll try to release it as a single dose treatment; silver lining is that the trials will be shorter.
So not all bad news. I'll be interested to see what the Day 210 results show. It still doesn't make sense to me that we have a positive anecdote that had meaningful improvements in word scores and 3 frequency bands. Also the positive patient has no tinnitus after 5 months from his last FX-322 dose and can hear birds and sing, that is a miracle.
Surely there would be others like him in the trial that are experiencing the same thing as him right now but haven't told Frequency Therapeutics yet.
No, Dr. Shore helped @linearb.
The University of Minnesota device helped @kelpiemsp but their lead (Hubert Lim) bailed on the device for Neuromod. Epic-level sellout.
Log in or register to get the full forum benefits!
Similar threads
