I have had occurrences of what @OptimusPrimed has described. Electrical chirps, tinny sounds, a tone that comes and goes. All from good old fashion noise exposure.
I have tinny sounds as well (in my case probably from my LF hearing loss). The "metallic sea shell" sound seems more unusual.
My imagination is that if the new Phase 2 is successful and they identify a target population that will benefit from FX-322, Phase 3 will investigate the appropriate interval between multiple injections.
If they do test out multi-dosing again, they should have it as a separate trial that does not delay the single-dosing trials. Let the single dose of FX-322 be approved and out in the market ASAP.
This article is specifically talking about plasticity towards transdifferentiation through things like ATOH1 overexpression (i.e. turning a support cell directly into a hair cell). This is more the Audion Therapeutics method than the Frequency Therapeutics method.
Interesting stuff. Definitely not to the level of the Meniere's Disease video. I have suspected Middle Ear Muscle Dysfunction may be playing a role, as those muscles can play a role is modifying how sound is transmitted from the eardrum to the cochlea. I have learned over time, that the "environment" or "state" of the middle ear, including the small air pocket and ability for air to pass out of the middle ear is important in transmitting sound effectively to the cochlea.
Blasts like from a shotgun can cause both secondary hydrops or a perilymph fistula. Look into both just to make sure you have ruled those in/out as a cause. It may not apply but it is something that you could be treating now and just not know it.
For that purpose, I think that the multi-dosing trial will be conducted in parallel with Phase 2 or will be conducted after it is put on the market.
Did you do a lot of shooting? I have major problems after exposure to 10 or 15 rounds from a small caliber handgun. Earplug didn't seal on the right side.
Yes.
I see it less as "natural degradation" and more a function of continued disease process.
I thought that the severe group would have fewer supporting cells so it would be less effective... I guess we will see.
You don't start to lose support cells until the profound range per a researcher who is working on "flat epithelia" told me. It's the very last thing to go.
I think this is a fair assessment assuming the product is approved.
I am all of those except for the word scores.
Before Phase 2 dropped, like a week before, someone called them and they were told there were going to be trials this year.
I think they told him Phase 3, but I'm not sure. I also don't know if the Phase 2 situation changed that.
Man, I'm hoping when they said additional trials later in the yea,r they were talking about Phase 3. Praying for positive outcomes for age-related and severe hearing loss trials.
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