Member- May 7, 2015
- 1,052
- Tinnitus Since
- 29.09/2014
- Cause of Tinnitus
- Acoustic trauma using headphones
Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
- Start date
Rings-a-Bell
Member
When they finally cure noise induced hearing loss and associated tinnitus, I wonder how many people will go back out to bars and concerts and give it to themselves a second time.
I think paranoia and PTSD from this BS has played with my brain enough that I'll sit in the woods and smoke cannabis until I die from happiness.
I don't know of any in particular. They are what they are, doing what they do very well as far as I know.
It's some people's expectations I have a slight problem with, and the only problem I have with people's expectations is the messages they then send to others. What people are being told is 'Forget about all those bullshit coping skills that you can practise right now. Just wait for the cure'.
Convince me that that's a healthy message and I'll stfu.
I'll hike the Appalachian Trail from GA to ME. Silence is golden (so I'm told).
Yeah. It's funny. None of them even acknowledge the others' work. A few weeks ago, the results of a study using yet another signalling pathway were reported on the web and the headlines were pretty much 'Hearing Loss May Be Reversible!', as if it were the first time anyone ever considered the possibility. We really need a benevolent dictator to co-ordinate all of this.
With what this stuff will cost I doubt people will be able to afford it twice.
Yup.
Vote JohnAdams Benevolent Dictator 2020!!
Seriously what if we had an intellectual leader that could blow Billions on this?
I know, I typed it out without thinking. I just saw "dick-tater" and ran with it.
Uf! My tinnitus was almost gone and I am here again. I'm feeling stupid right now
I hope these guys have the answer to our tinnitus.
What happens if I inject the drug within 5 or 6 years and 15 years later I need another injection due to a noise accident? I read that you were saying something about the space of the cochlea...
I also wonder what level of care should be taken while the regeneration process is taking place. What happens when growing cells are exposed to everyday noise?
I also wonder what level of care should be taken while the regeneration process is taking place. What happens when growing cells are exposed to everyday noise?
In fifteen years time there will be newer drugs and whole new therapies. Gene therapy will be an established mainstream treatment by then. Many people have their hearing damaged by noise, but it is believed that certain genes make some people more vulnerable to noise damage. Gene therapy will address that. With FX-322, I've never heard anyone say that it can only be used once.
Nothing's come out of Frequency Therapeutics that addresses that (that I've seen anyway). More likely, I think, that you need everyday sounds for the new cells to establish connections and for the brain to re-adapt to hearing more sound.
Interesting. I do not know if it will have something to do with that, but sometimes I accidentally expose myself to moderately loud sounds (and I worry) and find that after that moderate exposure my tinnitus decreases. I do not know if it's because the brain "receives sound" or because my mind filters it a little bit. Mysteries of tinnitus.
That's a great question. In 15 years regenerative medicine with probably be even more advanced so there's no telling.
Well, how loud does it get in the womb? Download the iPhone decibel meter app and find out.
Is there regenerative medicine in other fields than just the inner ear?
What makes us think the inner ear would be the only place?
What makes us think the inner ear would be the only place?
It's definitely not, just by fate the trail they followed led them to first attempt the ear.
David Lucchino talks about the possibilities in the Bloomberg podcast.
https://www.bloomberg.com/news/audi...iness-papa-ginos-rhode-island-elections-radio
Listen from 47:00 onwards
Okay I see the confusion here. I didn't mean to insinuate that the first trial proved it worked to regrow human hair cells. I was listing facts that have been previously discovered about this drug from other experiments. And it has been shown to regrow human hair cells, that's a fact.
They have regrown human hair cells.
View attachment 24064
The hair cells have ribbon synapses.
View attachment 24065
This video has probably been posted around this site multiple times. Especially in this thread. Maybe if you watched it you wouldn't be putting me on trial for being informed and doing research.
Not sure how I missed this over the weekend, but it's a more than 80 page thread and the statement regarding the first trial was confusing.
It's nice to see that it regrew hair cells in isolated human cochlea tissue. Hopefully they will be able to replicate that during in patient studies. I am rooting for them to succeed in their current and future trials.
Great questions and all reasons why the drug needs to go through the proper clinical trial process. As @Ed209 has pointed out, from a legal standpoint the drug company wants a solid understanding of long term ramifications.
I am guessing the procedure will be expensive, but similar procedures are already conducted. I underwent a series of intratympanic steroid injections and they were considered a surgical procedure for billing purposes. I think it was around $3,000 per injection procedure. There was some complexity given the level of care taken to not damage the ear drum. And since the steroid injections are given as a series over several weeks, the specialist also aimed for the same injection location every time.
Another point, due to the ear drum puncture, increased tinnitus was a potential side effect. The risk was worth it for me given my hearing loss.
So I guess I am advising that if this drug makes it to patient markets, based on the injection procedure make sure you see a skilled ear surgeon and not your everyday ENT.
The FDA does not actually test the drug themselves, the drug maker just reports their data and bureaucrats sign off on it. The only purpose of this is to make sure the drug maker doesn't make false claims about their product's safety or efficacy. The drug maker themself could test all of these things, and they actually do.
To incessantly keep claiming that the FDA process is immutably necessary is basically insinuating that Frequency Therapeutics would try and swindle and lie to us unless the government stops them from doing so.
It is Frequency Therapeutics that is actually doing the testing and paying for it, NOT THE FDA.
To incessantly keep claiming that the FDA process is immutably necessary is basically insinuating that Frequency Therapeutics would try and swindle and lie to us unless the government stops them from doing so.
It is Frequency Therapeutics that is actually doing the testing and paying for it, NOT THE FDA.
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