Frequency Therapeutics — Hearing Loss Regeneration

Does the brainstem count as brain? Where do you think ringing takes place? Not in the ears for sure. Doctors would be able to hear it. Assuming we are talking about subjective tinnitus.

I am inclined to think that even though hearing is restored that tinnitus will remain, at least in some cases.
It may remain in some cases? But that's good, right? If it remains only in some cases, it means that it will not remain in most cases. So in most cases it will be either reduced or cured.

The reason I say this is that there are for me personally so many other symptoms to T.
Did you mean to say causes for tinnitus? There may be several causes for tinnitus. But what can we do about it? I know complaining won't help. What is the most common cause of tinnitus? Or what is the most probable cause of tinnitus? The most common cause of tinnitus is noise induced hearing loss. Maybe I should say that tinnitus is most commonly associated with noise induced hearing loss. The hearing loss itself may be just a trigger as some of you have pointed out.

I suggest that we restore those sensorineural structures and see what happens. It may cure all forms of subjective tinnitus, or only tinnitus associated with noise induced hearing loss. It may cure tinnitus in this group, or only reduce it. It may not work at all! You may restore your perfect hearing, but you may still be stuck with tinnitus. Or it may take time for the brain to adjust itself to the new sound information coming in from the cochlea that has not been there for years. That may be the process that reduces or cures tinnitus. No one knows for sure.

No one knows for sure, because we don't know if tinnitus associated with noise induced hearing loss is actively sustained and generated by the damaged cochlea, or if the cochlea was just a trigger point and the noise generation takes place elsewhere.

Brain buzz and insane laser sounds when waking up that I simply do not believe are related to hearing loss.
How do lasers sound like? Like phasers in Star Trek?

Have you tried restoring your hearing loss lately? Maybe tried hearing aids?

Its something else, something chemical ... Maybe started with hearing loss but something happens in the brain.
What about the human body is not chemical?

Yes, that may be true. It may be triggered by hearing loss, and then go on to live a life of its own, higher up the system.

No one knows for sure... :dunno:

I know I have my doubts too. But we are just gonna have to sit tight and wait. Hearing loss in particular, but also tinnitus is finally getting attention in the media. Can hearing restoration reduce or cure tinnitus? Maybe... maybe not! We will know soon enough. We are finally on the brink of answering this question once and for all.

Well we have seen some cases of improved hearing reducing T (stem cell therapy, LLLT). But I am weary of accepting this as a solution.
Are you referring to Chloe Sohl? What is this LLLT case you refer to?

Chloe got cured of her tinnitus, didn't she?

Why would you not accept this? I know these are just isolated cases. Which is exactly why we need large clinical trials. So we should be cautiously optimistic.

What else could we possibly do?

I now have the electrical head buzzing as well and it does not seems like normal T.

What do you think causes it?

Here's my best guess in trying to have a positive approach: we know that hearing loss causes the nerves to become overactive, I think this causes a chain reaction to other surrounding nerves (some which can feel like they're buzzing) perhaps if the root of the overactivity (the hearing loss) were addressed, it would stop the chain reaction.

You don't guess, you either have a positive view or you don't. I think we have more than one reason to be optimistic. What you describe is the result of some of the latest research.

Chain reactions are stopped by breaking the chain. Assuming that cochlear damage is part of this chain that generates tinnitus, then repairing the damage in the cochlea may help break this chain. Perhaps not as much "breaking" the chain, as reducing the activity in the chain. Think of the way chain reactions in a nuclear power plant works, where control rods are normally used to apply some breaking power and reduce the nuclear reaction or fission.

However, if the cochlear damage is just the trigger point, while the tinnitus is sustained in a chain or loop higher up in the system, then repairing the damage in the cochlea may not do much to stop or reduce the hyperactivity in the circuit that generates the tinnitus.

For noise induced hearing loss I would think that restoration of the signals would reduce/eliminate T.

Assuming cochlear damage is part of the chain that sustains tinnitus.

You can look at examples where an injury has occurred T develops but over time the injury is repaired and T is eliminated.

What example? How long time? What kind of injury?... damaged cochlea I assume?

The brain is constantly interacting with your ears so if there is a change to your ears either negatively (more damage) or positively (restoration of damage) the brain should follow suit.

Assuming cochlear damage is part of the chain that sustains tinnitus.

This is one of the theories behind tinnitus, one I am inclined to believe in, or at very least see it tested. If it doesn't help we can move on to test other theories. The work that researchers have put into repairing cochlear damage is unbelievable. This is too good to be a complete flop! Even if it does not help tinnitus, which we still don't know for sure... even moderate success in restoring hearing will mean an enormous success for science.

I get that time is factor here but really I think that the brain will update to changes.
Yes, I think so too. At very least, tinnitus will be reduced. Assuming that the damaged cochlea is part of the circuit that sustains tinnitus.

Now if brain damage is the major cause of someones T then fixing the ears may not play a role.
Maybe... maybe not. If that is the case, we can move on to other theories.

What kind of brain damage would you expect to cause tinnitus? If cochlear damage causes hyperactivity in the auditory system, and that in turn generates tinnitus, then cochlear damage can be seen as a brain damage. If you consider tinnitus as a disease in its own right, rather than a symptom of a disease or a damage which it often is portrayed as.

this thing is in the head now
As opposed to in the ear? Subjective tinnitus has always been in the head. It's a perception of sound that doesn't exist. Where else would that perception take place?

the switch has been triggered and over excitement taking place
If the switch is the cochlea, and it's part of this evil circle generating tinnitus, then repairing the cochlea may help reduce tinnitus or even cure it.

this is where I see a solution for my type of t (have no obvious hearing loss), DNS or something that addresses the neuron's response...
No obvious hearing loss, but what about non-obvious hearing loss?

What is DNS?

Still studying the whole thing, very complicated...
Yes, it is very complicated. Thankfully, we have smart people working on solving the problem. We have several reasons to be optimistic.

Many of you seem to underestimate the importance of therapeutic hearing restoration. Or am I the one overestimating hearing restoration? As a cure for tinnitus? Maybe so, but I like to think that hearing restoration will serve as an important inroad for many different avenues of regenerative medicine, and we, as a group of people with tinnitus and/or hearing loss will finally get an answer to the big question. Can hearing restoration reduce or cure tinnitus? That's the million dollar question! Only time will tell for sure. It will not take long now till we get an answer. Frequency Therapeutics may be the first company to give us the answer. Till then, keep the hopes up!
 
Lets keep this thread about Frequency Therapeutics, their trial and they developments. Thanks everyone!!!

New press release
http://www.frequencytx.com/news-events/news-events-press-release-03-30-2017.php

"As a highly-regarded industry veteran, John brings us a wealth of knowledge and expertise," said David Lucchino, President, Co-Founder and CEO of Frequency. "John has already begun to help us accelerate the development of our pipeline of product candidates for hearing restoration."

"It is my pleasure to join Frequency Therapeutics as it begins clinical development of a treatment for hearing loss," said Dr. LaMattina. "The team has made remarkably rapid progress, and Frequency's Progenitor Cell Activation platform presents an exceptional opportunity to develop a wide range of new disease-modifying therapies for hearing and other areas throughout the body."

This is great news. They are serious.
 
@RB2014 Yeah, I just saw that. Was about to post it when I saw your update! :D

Dr. LaMattina previously was President of Pfizer Global Research and Development and Senior Vice President of Pfizer, Inc. During Dr. LaMattina' s leadership tenure, Pfizer discovered and developed several important new medicines including Tarceva, Chantix, Zoloft (PTSD), Selzentry and Lyrica along with a number of other medicines currently in late stage development for cancer, rheumatoid arthritis and pain. Dr. LaMattina is the author of numerous scientific publications and U.S. patents, and is the author of "Drug Truths: Dispelling the Myths About Pharma R&D." He currently serves as an Independent Non-Executive Director at PureTech Health.

I hope this will help bring them closer to the clinical trial.
 
What makes you say that?

Well this is the biggest pharma company in the world. In a way that's good because it means that Frequency is serious and people are confident in their technologies but big pharma companies are known for dirty money and moves and are the most important lobbyists.

22 billions dollar of net profit in 2013. Don't know what they are doing with all their money... They could cure loads of stuff with that.
 
Well this is the biggest pharma company in the world.
You sure you're not mistaking them for Johnson & Johnson?

In a way that's good because it means that Frequency is serious and people are confident in their technologies but big pharma companies are known for dirty money and moves and are the most important lobbyists.
But Dr. LaMattina is no longer affiliated with Pfizer? Is he?

"Dr. LaMattina previously was President of Pfizer Global Research and Development and Senior Vice President of Pfizer, Inc."

You sure Frequency did not hire Dr. LaMattina for his professional merit?

"During Dr. LaMattina' s leadership tenure, Pfizer discovered and developed several important new medicines including Tarceva, Chantix, Zoloft (PTSD), Selzentry and Lyrica along with a number of other medicines currently in late stage development for cancer, rheumatoid arthritis and pain."

Or for his academic merit?

"Dr. LaMattina is the author of numerous scientific publications and U.S. patents, and is the author of "Drug Truths: Dispelling the Myths About Pharma R&D.""

He is affiliated with another Langer company.

"He currently serves as an Independent Non-Executive Director at PureTech Health."

22 billions dollar of net profit in 2013. Don't know what they are doing with all their money... They could cure loads of stuff with that.

if they can figure out T, they can take all the money I have

It's not always about the money.
 
I think it's a good news that they hire Dr. Lamattina http://finance.yahoo.com/news/former-pfizer-r-d-president-121900485.html

Nice background

And it means frequency Therapeutics are moving and believe in their project. A Dr with this background is not cheap

Is FT a private or public company?

I only hope they are not doing this kind of move only to go IPO and raise money ...
 
Wow. I didn't realize this was the fruition of 7 years of research. And its been tested on primates. Good work on them. I just wish the neuron regenerating labs were as devoted to bringing something to market.
 
They have updated their website with a new Community section:
Frequency is committed to building a community and sharing resources as part of our mission to fundamentally change how noise-induced hearing loss and other conditions and diseases are treated. Sharing the stories of people and their diverse experiences not only helps to bring a group of individuals together, but it also spreads awareness about under-recognized conditions that can affect millions of people. We believe that information is both empowering and vital to tackling difficult challenges. On these pages, we are actively collecting and sharing information about the diseases and conditions being addressed at Frequency. If you have resources that you would like to suggest or have a story to share, we want to hear from you. You can contact us here.

Guess we could send them something about tinnitus, hyperacusis, etc.?
 
This is fantastic. It might mean that they want to understand better who the patients are... So it's not just "let's cure hearing loss", but more "let's see how hearing disorders affect the people out there and how it could connect to our research".

It might also mean that they are working on inclusion criteria for their clinical trial...

Each of us could write to them. Write something short and powerful about your story.
 
I would be happy to do that and explain how important I think their research is. But are you sure this is what they want? I only see general inquiries and media inquiries. It is not so clear to me.

I looked at that as well. I think they just came up with the idea to send the stories but probably didn't update the contacts page to as how this should be done. Its the vice president of finance and operations or media inquiries. I was going to email them to see if I am illegible for the trial, but I'm waiting for the proper contact info to be put up.
 
Just have call out to Richard Mitrano at Frequency telling him that a lot of people at tinnitus talk are interested in sending stories and talking about hearing loss. Thanked him course for the work they are doing and a lot of people are hoping this is the key. Left a message at his office.
 
There is no trial yet so there are no inclusion/exclusion criteria.

Agreed. I still think the inclusion/exclusion criteria is going to be very stringent. I just can't see someone with mild hearing loss walking in there, having the trial performed and 2 months later having to get a cochlear implant if the procedure didnt work or the dosing turned out to be ineffective and they went completely deaf. That would be a serious life changer.
If I were to guess the hearing loss would have to be around 80db in losses, not to little and not to much. No genetic defects. Hearing loss mainly caused primarily by noise induced factors. It will be similar to what Novartis had set.
Once they determine effectiveness I'm sure everyone will get a chance to try it out, but people have so many variables that go along with their hearing loss. Ideally this would work for all of them.
 
If I were to guess the hearing loss would have to be around 80db in losses, not to little and not to much. No genetic defects. Hearing loss mainly caused primarily by noise induced factors. It will be similar to what Novartis had set.

Ugh then they might have trouble finding people for the first portion. If that is the criteria it would be wise for them to start seeking and sorting candidates in the spring of 2018 if they plan to deliver the substance in the fall of 2018
 
@RB2014 You bring up a good point. If any other companies were to gene therapy like Decibel they probably would also have very limited initial trial criteria which would slow down the whole process. So a phase 1/2 might take 2-2.5 years instead of 1.5 years.
 
"Our data is very compelling and we are excited to be moving to the clinic in the next 12 to 18 months". Nice to know it's not still 18 months even though some months are passing lol
 
I still think the inclusion/exclusion criteria is going to be very stringent.
I am not sure this is true with regard to hearing loss. I think it is possible the trial could include people in the mild to moderate range rather than the severe to profound range though I would expect that they would pick one or the other.

I don't think there will be a phase I trial in healthy volunteers. I would expect a Phase I/II trial like Genvec/Novartis. I think the frame of reference people have for inclusion criteria is Genvec/Novartis. It's true that Frequency's trial (assuming we get to one) will be the first trial using their PCA approach, and this argues for strict criteria. However, they are very different in at least 1 fundamental way. Assuming Frequency is able to continue to use injections into the middle ear, their approach is much less invasive so the risk of damaging hearing based on the procedure is much lower for Frequency. Additionally, even if it "works" I don't think the target market for CGF166 is people with mild hearing loss whereas my sense is Frequency is going for a broader market.

This is of course speculation on my part, and we will have to wait and see what happens.
 

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