Frequency Therapeutics — Hearing Loss Regeneration

[Flamingo1]

http://www.xconomy.com/boston/2017/...ill-push-hearing-loss-drugs-to-human-studies/

They will have to figure it out!! They got 32 million dollars!

They will figure it out. I just read the journal article. (Thanks, @addot) It all looks very promising. Half the problem is figuring out what the problem is which they already have with respect to adult hair cell regeneration. The other half is finding a solution on which they have plenty of ideas. If I could buy stock in Decibel or Frequency to support their efforts, I would in a heartbeat!

 

[Iliasp]

When do we expect the next one?

 

[Freeatlast]

They will figure it out. I just read the journal article. (Thanks, @addot) It all looks very promising. Half the problem is figuring out what the problem is which they already have with respect to adult hair cell regeneration. The other half is finding a solution on which they have plenty of ideas. If I could buy stock in Decibel or Frequency to support their efforts, I would in a heartbeat!

But isn't tinnitus due to hair cell damage just a theory?

 

[addot]

But isn't tinnitus due to hair cell damage just a theory?

It's a theory, but I think is a very convincing one. That hair cell damage (or even synapse damage, which is easier to occur) triggers tinnitus seems to be widely accepted. The question remains if reversing the damage can reduce or eliminate it. Some hearing aids/cochlear implant users report a reduction in their T levels (though I can't remember the exact source for this), so maybe restoring the hair cells and their connections does the same.

 

[RODRIGO]

It must be taken into account that cochlear implants do not transmit sound reality like hair cells. So its effects on the reversal of tinnitus should be lower than those of the recovered hair cells. I think that if the hair cells are recovered there are quite a few chances that the tonotopic map will recover the previous state .. better than with an implant.

 

[Michael Larsen]

It's a theory, but I think is a very convincing one. That hair cell damage (or even synapse damage, which is easier to occur) triggers tinnitus seems to be widely accepted. The question remains if reversing the damage can reduce or eliminate it. Some hearing aids/cochlear implant users report a reduction in their T levels (though I can't remember the exact source for this), so maybe restoring the hair cells and their connections does the same.

https://www.ncbi.nlm.nih.gov/pubmed/17260883

 

[Jomo]

yeah even residual inhibition supports this idea. You can hear the tone of your T and all of a sudden you have relief for a few seconds. Once they fix the hair cells that correspond to the tone we should be cured or at least lessened. I hope that day comes soon. EDIT: i would like to add that i have noticed that residual inhibition has become less effective for me as my time with T continues but it could be because I am not hearing the exact tone I need to hear. My T sounds has changed as time has passed. In the beginning though it worked very well. During my first week I found the T tone and I had relief for an entire night. I enjoyed that nite relaxing in silence knowing that it would prob be my last time.

 

[Mentos]

yeah even residual inhibition supports this idea. You can hear the tone of your T and all of a sudden you have relief for a few seconds. Once they fix the hair cells that correspond to the tone we should be cured or at least lessened. I hope that day comes soon. EDIT: i would like to add that i have noticed that residual inhibition has become less effective for me as my time with T continues but it could be because I am not hearing the exact tone I need to hear. My T sounds has changed as time has passed. In the beginning though it worked very well. During my first week I found the T tone and I had relief for an entire night. I enjoyed that nite relaxing in silence knowing that it would prob be my last time.

Somehow residual inhibition never worked for me, but perhaps it because my T is not tonal but broadband (I hear something like needles falling on the floor) so I cannot find a tone corresponding to my T. Anyone here with similar broadband T like mine for whom residual inhibition worked?

 

[Iliasp]

https://jamanetwork.com/journals/ja...MAPublishAheadofPrint&utm_campaign=07-07-2017

Good ending

 

[tomytl]

https://jamanetwork.com/journals/ja...MAPublishAheadofPrint&utm_campaign=07-07-2017

Good ending

puhhh, yes.... hope Mr. Karp is very right....
Usually all this press articles always starts with "cure of something" and ends "it will take many more years"
Research is generally slow, especially for people like us... but there are also some coincidences and fallbacks,
we never know if it's 5,10,15,20,25 or 100 years away...

 

[Rubenslash]

puhhh, yes.... hope Mr. Karp is very right....
Usually all this press articles always starts with "cure of something" and ends "it will take many more years"
Research is generally slow, especially for people like us... but there are also some coincidences and fallbacks,
we never know if it's 5,10,15,20,25 or 100 years away...

Has been posted here weeks ago

 

[DoNotGoGentle]

My guess is the first treatments won't be perfect and won't work for everyone! 5-10 years us hard of hearing will have options more then hearing aids!

 

[Flamingo1]

My guess is the first treatments won't be perfect and won't work for everyone! 5-10 years us hard of hearing will have options more then hearing aids!

At least there's hope now!

 

[Flamingo1]

If Karp right, how is it that they improved the hearing in rodents using this exact same method?? I agree that the method may not work for all, but the approach should work for some!

 

[FIGHT]

"Edge, meanwhile, has cast his lot with the Dutch company Audion Therapeutics. Partnering with Eli Lilly, they too are anticipating human trials as early as 3 to 5 years from now, according to Edge."




Is this true?

 

[Rubenslash]

"Edge, meanwhile, has cast his lot with the Dutch company Audion Therapeutics. Partnering with Eli Lilly, they too are anticipating human trials as early as 3 to 5 years from now, according to Edge."




Is this true?

There is a thread about Audion, it should be 1 year from now instead of 3-5 though.

 

[acufenero]

"Edge, meanwhile, has cast his lot with the Dutch company Audion Therapeutics. Partnering with Eli Lilly, they too are anticipating human trials as early as 3 to 5 years from now, according to Edge."

Is this true?

It isn't, since the trial is expected to start in August/September. Check this and this.

 

[FIGHT]

It isn't, since the trial is expected to start in August/September. Check this and this.

According to edge in this article.

https://jamanetwork.com/journals/ja...MAPublishAheadofPrint&utm_campaign=07-07-2017

 

[swc5150]

The article makes it sound as though the race is on, and Dr. Karp intends on being first to the finish. Good stuff!!

 

[Paulmanlike]

According to edge in this article.

https://jamanetwork.com/journals/ja...MAPublishAheadofPrint&utm_campaign=07-07-2017

That's the Audion trial, the frequency trial is expected to start sooner?

 

[david2017]

Hello

I'm a new member here and need to ask a question:
I have a congenital hearing loss and right now I'm following some research like Regain Project and Frequency Therapeutics.
I often read that it may only help those who have had normal hearing loss and suffered hearing loss afterwards.

I hear very good with hearing aids, but I wish if I could ever operate and stop using them.

I just need to know what is available to help those who have congenital hearing loss?


Thanks so much

 

[Rubenslash]

Hello

I'm a new member here and need to ask a question:
I have a congenital hearing loss and right now I'm following some research like Regain Project and Frequency Therapeutics.
I often read that it may only help those who have had normal hearing loss and suffered hearing loss afterwards.

I hear very good with hearing aids, but I wish if I could ever operate and stop using them.

I just need to know what is available to help those who have congenital hearing loss?


Thanks so much

If you do have supporting cells left than these treatments might work for you as well.

 

[david2017]

Thanks for a quick reply, what is meant with supporting cells?
And how do I know if I have or not?

 

[Paulmanlike]

Thanks for a quick reply, what is meant with supporting cells?
And how do I know if I have or not?

Supporting cells are those cells that surround the inner hair cells, they are not sensory cells but help keep the cochlear intact/together.

There is no way to objectively determine if you have them or not but many people will. If you have a profound hearing loss however there may be none.

 

[david2017]

I get reply from Regain :

Dear David



Thank you for your email and for providing more information. As you point out, there are different causes of hearing loss, and the drug being tested in this study is not a treatment that could help to treat congenital hearing loss, unfortunately.

 

[acufenero]

I get reply from Regain :

Dear David



Thank you for your email and for providing more information. As you point out, there are different causes of hearing loss, and the drug being tested in this study is not a treatment that could help to treat congenital hearing loss, unfortunately.

Frequency co-founder David Lucchino said last month in a radio interview that these kind of treatments most likely won't work for "genetic hearing loss".

I feel sorry for you

 

[david2017]

Frequency co-founder David Lucchino said last month in a radio interview that these kind of treatments most likely won't work for "genetic hearing loss".

I feel sorry for you

I don't know if it's genetic hearing loss. no one of my parent have hearing loss no one om my grandmother grandfather have hearing loss.
For some reason, I get hearing loss when I was born.

 

[tomytl]

I don't know if it's genetic hearing loss. no one of my parent have hearing loss no one om my grandmother grandfather have hearing loss.
For some reason, I get hearing loss when I was born.

but probably hearingrescue.com are something close on correcting genetic hearing loss.

 

[Iliasp]

Gene therapies will work for you

 

[david2017]

Gene therapies will work for you

Thank you for your reply, which one of them is?