MemberHearing aids don't do anything to supporting cells, they work like simple microphones amplifying the damaged hair cell regions.
Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
- Start date
there needs to be a Faq and updates in this thread about Frequencies progress and questions it's turning into a cesspool of repetitive questions.
This is just conjecture (like most everything else in on TT!
) but in academics things start picking up again in the Fall. Summer is pretty much their slow season. Maybe THAT'S the hold up.
Synaptic connections are far more prone to permanent damage then hair cells are.
I am wondering if growing new hair cells will make up for the synapse damage?
as well as if ultimately reversing hearing loss would reverse tinnitus outside of an acute phase.
If you read through this thread, there has been discussion on this. Basically, FX researchers believe that when hair cells are regenerated, they will connect to (or regrow?) synapses as part of the natural development process.
There are some other companies specifically working on drugs to repair synapses. You can find these listed in the "Inner Ear Hair Cell Regeneration - - Maybe we can Know More" thread.
Yes I knew if it works correctly new hair cells will come with functioning synapses
But what about the hair cells that still exist with damaged synaptic connections?
I think those drugs are still in their pre-clinical infancy or only work in a acute phase like NT-3.
https://www.nature.com/articles/srep24907
Even if it doesn't repair synapses in already dying/damaged hair cells, the theoretical improvement in T tone would make those hair cells irrelevant, if it can turn a loud T tone into a sleight hiss in a quiet room then they've essentially cured 90% of people's problems with T sans any further neurological problems like Visual Snow that may accompany it. Plus it opens up studies into the unthinkable option of killing off the already damaged hair cells with frequency spot "treatment" so that they can regrow with an injection.
I am strongly subscribed to the idea that reversing hearing loss will treat tinnitus by neuroplasticity being a both way ticket.
Street Novelist
Member
- Apr 2, 2018
- 290
- Tinnitus Since
- February 2018
- Cause of Tinnitus
- Listening to loud music through headphones
PetitGarsTimide
Member
- Jan 6, 2018
- 225
- Tinnitus Since
- 2016
- Cause of Tinnitus
- Dumb teenager who listened to loud music everytime
))
I think that was a separate experiment they had done, it is unfortunate that they cannot do both.
http://www.frequencytx.com/our-approach/hearing-and-beyond.php
They describe their procedure here and do not mention vestibular hair cells.
Hmm, in this news, the hearing loss program isn't mentioned....hope this doesn't mean anything bad.
Frequency isn't just for hearing loss. It works around a tool to activate dormant progeintor cells in the body and tell them to turn into healthy functional tissue
Hearing, eyesight, skin, muscle tissue ect..
Hearing loss is just their first application and very lucky for us!
Fasinating indeed. Never underestimate the power of science. I look forward to the day I will regain my eternal silence.
Street Novelist
Member
- Apr 2, 2018
- 290
- Tinnitus Since
- February 2018
- Cause of Tinnitus
- Listening to loud music through headphones
until the fall? Ah, fuck me! Are these guys all on vacation? Is that why I haven't been able to get a response?
I'm guessing the reason you haven't got a response is that they have very tightly controlled lines of communication to the outside world. If they didn't they'd be jumping on here talking about what they do, putting to bed the many misconceptions that they probably have a good laugh about. They are giving away absolutely nothing. So, when you and hundreds of others email them saying 'when's the trial starting? pick me, pick me!', they really have nothing to say to you. Sad but true.
When it happens it will probably be farmed off to a third party anyway. You could register for email updates at https://www.centerwatch.com/clinical-trials/pns/.
Nothing on clinicaltrials.gov and the pdf looks a bit amateurish; nonetheless:
https://www.alamoent.com/wp-content/uploads/2018/07/Hearing-Loss-Study.pdf
or go here https://www.alamoent.com/doctor/jeffry-rosenbloom/ and click "view current hearing loss study".
As you can see, there is almost no information about inclusion/exclusion or about duration (or anything really).
Apparently being administered by "Worldwide Clinical Trials" at their San Antonio location though it isn't listed on their site yet. According to his linkedin profile, the Jeff Holland listed in the pdf owns "Texas Quest Medical Research". He has "liked" a number of Frequency news items, as has Rosenbloom, which suggests there is some connection.
Given their size, Frequency is going to farm out trials to CROs. Still this seems like an odd set-up with Rosenbloom as the local PI, but the trial apparently taking place at WCT rather than Alamo and Holland coordinating even though he works for neither WCT or Alamo.
Hopefully the clinicaltrials.gov entry will provide more information.
https://www.alamoent.com/wp-content/uploads/2018/07/Hearing-Loss-Study.pdf
or go here https://www.alamoent.com/doctor/jeffry-rosenbloom/ and click "view current hearing loss study".
As you can see, there is almost no information about inclusion/exclusion or about duration (or anything really).
Apparently being administered by "Worldwide Clinical Trials" at their San Antonio location though it isn't listed on their site yet. According to his linkedin profile, the Jeff Holland listed in the pdf owns "Texas Quest Medical Research". He has "liked" a number of Frequency news items, as has Rosenbloom, which suggests there is some connection.
Given their size, Frequency is going to farm out trials to CROs. Still this seems like an odd set-up with Rosenbloom as the local PI, but the trial apparently taking place at WCT rather than Alamo and Holland coordinating even though he works for neither WCT or Alamo.
Hopefully the clinicaltrials.gov entry will provide more information.
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Why would they perform this in San Antonio and not in CT or MA where their bases are? Are they required to have a third party involved because of potential conflicts of interest?
Something seems off, this is the next step in an idea that is worth billions and could have massive implications on the world, and they quietly announce phase II trials with a couple of simple slides? No announcements on their website or twitter either. I hope there is more to the story.
Something seems off, this is the next step in an idea that is worth billions and could have massive implications on the world, and they quietly announce phase II trials with a couple of simple slides? No announcements on their website or twitter either. I hope there is more to the story.
I find it interesting they say that it is located at the "Phase I Unit". Not sure if this is just the name of the building that gets used for a lot of Phase I work or are they doing more "Phase I" work before moving to a costlier phase 2.
Innovative research to potentially restore hearing damaged by noise or acute loss is being investigated by Dr. Rosenbloom.
This statement is in the clinical trial posting. When stating acute loss, they mean sudden hearing loss correct? I have not seen this acute mentioned previously regarding Frequency Therapeutics. I'm curious why this has now been added unless I just missed this previously. I had sudden hearing loss so I'm hoping there might be something to this.
This statement is in the clinical trial posting. When stating acute loss, they mean sudden hearing loss correct? I have not seen this acute mentioned previously regarding Frequency Therapeutics. I'm curious why this has now been added unless I just missed this previously. I had sudden hearing loss so I'm hoping there might be something to this.
I'm concerned with the development of dementia after my hearing loss. How do you think the regeneration of hair cells will affect cognitive function. Will there likely be cognitive improvements?
I'm a software developer by trade but I hold a BS degree in biomedical engineering technology and my best guess would be no, however this is unknown territory and the true answer is probably beyond even the people developing this technology. I would honestly think that they may even unlock the secrets of dementia and alzheimers sooner than that of tinnitus.
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Hi all,
I am affected by the disease alport syndrome. my doctor told me that the disease causes a genetic defect responsible for the fact that hair cells in the inner ear die off. The hearing loss is probably in the middle range, I was told.
Does any of you know if Frequency Therapeutics' could be successful here?
I am affected by the disease alport syndrome. my doctor told me that the disease causes a genetic defect responsible for the fact that hair cells in the inner ear die off. The hearing loss is probably in the middle range, I was told.
Does any of you know if Frequency Therapeutics' could be successful here?
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