Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
- Start date
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Tell that to the investors that lost millions. They misrepresented data and their stock got burned. They are a laughing stock.
Watch the video bro. How is regenerating synapses not a treatment for synaptopathy?
Ok stop worrying about ribbon synapses. FX-322 or whatever does everything.
Will McLean of Frequency Therapeutics talks about this. Skip to 16:50:
We just have to wait.......
Just watched the video, holy shit.
Why isn't this the top priority of the world right now? Do you know how lucrative this could be? Don't people want to make money?!
I'm baffled right now that this dude has essentially cured hearing loss (possibly tinnitus) yet this is still in the grass roots phase.
The stock dropped because the trial was a farce, which was why the stock dropped by 92 percent. I am sorry you were taken in by it, smart guy.
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Are you a market analyst or a researcher? Pharmaceutical companies are extremely volatile, especially the smaller ones who only have a few compounds in development. If endpoints aren't met during trials the stocks will plummet. These companies usually operate at a loss while going through trials.
What evidence do you have that the trial was a farce?
Discovery science clearly does not involve selling to market, save for milestone payments, of course they will burn through cash, don't pretend that their stock crashed because they weren't making money, it crashed because their trials were a disaster.
The problems arise when investors believe the company is not being honest about the data in a timely manner, many investors that dumped this company did so because of a sequence of failures not just one single event, when companies start changing protocols and putting out press releases to try and keep shareholders on ice it leads to suspicion & fear.
We are talking about a company that was trading at highs of over 70 dollars in January 2016, and now they can barely break a dollar.
Forgive me for saying this but you clearly have some sort of affection for this company & I don't understand why.
I have stated many times, that I don't really have a "personal" dog in this race, I don't care who it is that brings success, but if we are being realistic here, I don't think it's going to be Auris Medical.
You're welcome. I came across it and posted the link within about an hour of it being posted on YouTube so it's not surprising you didn't see it. Not the slickest public speaker in the world though.
That's going to be true for virtually every company that has a single promising drug that fails during phase 3 of clinical trials when they have no other product lines to fall back on. Investing in pharmaceuticals is extremely speculative. If you look at the biggest gainers and losers on any given day, I can almost guarantee you are going to see some pharmaceutical / biomedical companies on the list. Hindsight is 20/20, they failed therefore the trial was a disaster and a scam. Auris could have handled the press release better, but that doesn't mean the trial was a scam, their stock would have tanked either way.
There were problems with the trial, mainly the assumption that you have 3-6 months before tinnitus is centralized. The window of opportunity (if there is one) is likely much shorter, but that doesn't mean it was a farce.
It is strange that both bimodal stimulation for tinnitus and regenerative drugs are both going to come out around the same time. Two different treatments for the same problem for the first time in history.
It's because these people aren't aware of each other. I just got a huge insight into this entire world.
The tinnitus research community is small. All these people at Tinnitus Talk, the ATA, and the BTA know each other. Many of them aren't even aware of FX-322 or that it may cure half or more tinnitus cases. I know some at the ATA aren't aware of it and I wouldn't be surprised if none of them knew about it. They seem to kinda have tunnel vision about current research and technology. They seem to just not get what a power player FX-322 could be if it works. Kinda sad but also kinda understandable, there has been nothing like this before.
I'm right, there needs to be a halt in almost all other areas of tinnitus research and all eyes on Frequency Therapeutics just because their human trial data will be a huge leap forward in understanding.
What needs to happen is that Frequency Therapeutics needs to be able to share their private efficacy data at the end of this trial.
How do I know they will have it?
Well, they are giving the drug, and the trial participants have prior audiograms, and all they have to do is conduct another set of hearing tests. There's your efficacy data.
The drug works in mice, it will probably most likely work in humans. Our round window membrane is much larger than that of a mouse.
People are just stupid.
Forget bimodal stimulation. We absolutely want regenerative medicine. Besides FX-322 may even beat bimodal to market. Unless the NPCs foil us.
Will regenerated hair cells work just as good as the natural ones, yes or no, or we don't know?
Do birds with regenerated hair cells have natural hearing or does it come back lower quality?
Do birds with regenerated hair cells have natural hearing or does it come back lower quality?
I think this is a good place to investigate once we confirm that treatment is working on human subjects.
1. Does the treatment bring back hearing?
2. If so, what is the quality or frequency average that is recovered.
We should still investigate potential regeneration of damaged/dead cells in case this doesn't work or only works in certain circumstances.
Also, previously mentioned on a Frequency Therapeutics video was that there was a maximum capacity of hair cells that can occupy the space on the cochlea (paraphrasing). This means that additional damage after treatment of FX-322 may actually limit efficiency of future treatments.
For example, if a soldier loses hearing, gets treatment and recovers but then gets hearing damage again may have to get a different drug or treatment if no more hair cells can be created w/ FX-322.
It may give us a second chance, but we still need to find a solution for regenerating existing hair cells/nerves.
Maybe. When sharks grow back their teeth it works. When lizards grow their tails back, it works. So... there's a chance.
Wouldn't it help if they applied the molecules to copy progenitor/supporting cells after the treatment of FX?
If they divide the cells then change them to hair cells, they are still going to need supporting cells.
I wouldn't worry too hard about that other stuff. We should ask more questions about the dormant spiral ganglia neuritis that actually connect to the main nerve we are trying to send messages through. Someone has to send Karp a specific email about the ganglia. Synapses and hair cells wouldn't really matter without them.
They already thought of that. Go check out the Will McLean presentation. They do multiply the supporting cells.
The point is that there is a limit of space in the middle ear. Once it is taken up, no new cells can be generated. If all of the cells are dead and no new cells can be generated, they will have to be repaired to work.
That's just one step of the process though, it's just not wise to put all eggs in one basket.
But don't supporting cells aid damaged cells? Even if it's damaged, wouldn't that trigger the supporting cells natural response to replace or treat the damage?
Edit: also why would supporting cells move if they couldn't effectively aid a different area? It would seem like they'd stay in the same place if they really couldn't do anything.
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"Following trauma or toxicity, supporting cells can eject injured hair cells from the epithelium, phagocytose hair cell debris, and in some cases, generate new hair cells"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005836/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005836/
PolishSoldier87
Member
- Jan 16, 2018
- 209
- Tinnitus Since
- 12/2017
- Cause of Tinnitus
- acustic trauma, neuro-lyme/rx co-op toxins
It is how FX-322 works. It's dividing progenitor cells and differentiating them to HC.
"PCA Regeneration transiently causes innate progenitor cells to divide and differentiate to initiate repair, in a way similar to naturally regenerating tissues such as the skin and intestine."
PolishSoldier87
Member
- Jan 16, 2018
- 209
- Tinnitus Since
- 12/2017
- Cause of Tinnitus
- acustic trauma, neuro-lyme/rx co-op toxins
1) Hair cells are placed in the inner ear
2) If a hair cell doesn't work, probably it doesn't exist
They do for other species, researchers have been trying to figure out how to make them do just that. But they don't kick on in mammals to regenerate hair cells. They are still looking for the magic concoction that will work, but we won't know for a long while.
The reason FX-322 is such a big deal is because it is closer to release and has the potential to reduce/cure tinnitus. FX-322 creates new progenitor cells along with nerve synapses/supporting cells and will divide into hair cells at once instead of utilizing the existing support cells to regenerate hair cells.
1. Yeah I wrote that quickly, it is the inner ear.
2. Or it has been ejected by the supporting cells if it was damaged:
"Following trauma or toxicity, supporting cells can eject injured hair cells from the epithelium"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005836/
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