i hate when people speak in scratchy loud or whiny voices. It sounds so loud and stressful. It's so much worse than tinnitus. Tinnitus barely bothers me anymore.
Dude, mammals don't restore hearing, we just don't. It was pretty much enough for me to know it restored hearing in mice. Genetically similar and mammal. Now not all drugs work on humans that work on mice but this isn't a drug. It worked on human hair cells and it's going to work on live humans.Difficult to rein in enthusiasm. But I am not Data or Spock from Star-Trek
Also I am reluctant to put all eggs in one basket.
Yeah flying small aircraft damaged my hearing. You'd never hear a word your copilot said if you didn't have a mic and this goes on for hours. Sounds like your dad likely did the most damage to his hearing in the navy if he was in jets. They start those things up with your face next to them. I can't fly anymore unfortunately because of my hearing.
I wonder how different in vivo and in vitro is when it comes to cellular biology.
Even when my hearing was OK I wondered about this sound level of headphones in small aircraft. This after a flight with an instructor. Boy was that loud! Now with my hyperacusis I will no way be doing that again.
Well, they probably know at this point. The mice studies didn't say it took 3 months to see a change, it said that 3 months was the point where it stopped getting better.
Not necessarily unfortunately, we do not know the dosages given and the dosage needed for a certain amount of growth.
Where did you get that they will start doing different dosage levels "deep into phase 2, 2.5"? Post a link or admit you just made that up please.
True thing...
I feel like I'm in the twighlight zone reading some of the arguments about this. There is super evidence that points to this as being the cure for most tinnitus cases.
"The randomized, double-blind, placebo-controlled trial will assess the safety of FX-322 given by intratympanic administration in adult patients with stable sensorineural hearing loss (SSHL)"
Hold on there mister. Your original comment was that they are going to start testing different dosage levels "deep into phas 2, 2.5". Which is wrong, they are doing that in this phase.
This is my entire point! There is a formal process being followed that needs to be not followed to the T because there are many people on the brink of killing themselves and their lives are deteriorating and deserve help as fast as humanly possible. The process is not as fast as it could be!
What would the point be of proving something is safe for 10% of the actual dose you expect is needed? I think they are using the doses they plan to use in any further trials.
Hearing has a natural tendency to come back to a certain extent on its own, I wonder if this comes into play? After a recent acoustic trauma, I went from hardly being able to hear, to a gradual improvement over a few months doing nothing at all. If I were taking a drug, would that drug be given credit for my limited recovery?
They can easily compare to mice who didn't get the drugs and measure the difference.
Good point. My only rebuttal is that we know sound is transmitted from the hair cells and that this method definitely regrows the hair cells.
I would assume that they had another group subjected to the same amount and level of sounds that were not given the solution. They had to endure everything without any prospects of healing so they'd have to compare.
Man the mice in both groups were made deaf and the mice treated responded to the sound and the ones not treated did not. That's how you know it's not natural recovery. I think what would be helpful is if some of the people who don't believe understood the science behind it better. They even used the drug or one that is similar to induce hair growth in mice. Hearing loss isn't the only application.
I didn't say I didn't believe, it was just a question. I didn't know there were two groups subjected to the same.
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