Frequency Therapeutics — Hearing Loss Regeneration

[Greg Sacramento]

This latest run up is bananas. It's not clear at all what's driving it. Otonomy (OTIC) has also been climbing, but not as fast and they have trial data due this month.

Zack's just published "Find Strong Stocks with this New Analyst Screen". Frequency Therapeutics is mentioned. Reason they gave for run-up in last 30 days is because of increase of analysts from 2 to 3. I do agree with this as being one reason and will place this as reason 2.

The top reason is demographics, meaning many investors have association to sites like here and then past thoughts on to relatives and friends by word of mouth. I would say that at least 25% of volume is from this. Also many of the investment funds that are invested in FREQ are well known to invest in small volume companies where private investors have a special interest.

At the close of market today, the Ameritrade research team advised to reduce positions. I had posted to buy at 21, a month or so ago, but there may be some profit taking until we get closer to new data readouts.

 

[sami23]

Yes, noise affects support cells but it depends on the volume level/time of exposure.

It would be interesting to know how much noise affects it, if the cell would be still able to regrow or no.

 

[wsbreaker]

So, it means the Phase 2A trial could be the final trial? Or will it be followed up by a Phase 2B?

 

[sssing]

Thank you! I forgot about this but is it still not odd that most of the gain was made in the last two weeks given that report came out on 16 November? I'm new to markets and trading so maybe this is par for the course. Should we expect FREQ now to hover around this price until Phase 2 results come out?

Could it be because there was a report on it here?

https://finance.yahoo.com/news/strong-stocks-analyst-coverage-screener-012701683.html/URL]

 

[sssing]

I used to be on this thread a couple of years ago and they've always grown back slightly odd. That doesn't mean they aren't fully functional. Especially due to the progress we've seen time and time again in their clinical trial phases. If they are confident in the functionality and longevity of the hair cells, then we don't have a reason to question it.

Really most questions here have been asked and researched multiple times before. I take the fact that this thread is still going to be a healthy sign of optimism. They aren't marketing a word recognition drug, so it must mean they're seeing positive results in people's hearing as well.

Maybe it'd benefit us to look for evidence stating that hair cells shaped that way aren't functional.

On my good days, I don't think about such things as you mentioned above but on my bad days I do wonder. But I'm glad I have people here who keep telling us to hold onto hope. That's what I'm trying to do. No one understands how damaged ears damages life...

 

[sami23]

I found an interesting picture of a mouse's cochlea after FX-322 injection.

Here it is:

Hair cells created are in good shape in my opinion.

 

[Rb86]

Is Phase 2A going to show us how trial participants' tinnitus was affected by FX-322?

 

[xyz]

I found an interesting picture of a mouse's cochlea after FX-322 injection.

Here it is:

View attachment 42178

Hair cells created are in good shape in my opinion.

Is this a picture from the Russian FX-322 study?

 

[serendipity1996]

Is this a picture from the Russian FX-322 study?

There hasn't been an FX-322 study in Russia.

 

[xyz]

There hasn't been an FX-322 study in Russia.

I was just wondering where that picture comes from. For OTO-616 Otonomy has released such pictures but Frequency Therapeutics did not so far as I recall. So it would be nice to have a source for that.

 

[sami23]

I was just wondering where that picture comes from. For OTO-616 Otonomy has released such pictures but Frequency Therapeutics did not so far as I recall. So it would be nice to have a source for that.

That picture is from a Russian doctor but I don't know where he got it.

 

[twa]

View attachment 42176

These pics do look very similar. The pictures I remember were side by side pictures of original hair cells that were straight and the new hair cells were zigzag on the right. I will keep looking...

 

[twa]

Since he is under 85, he qualifies for the age-related trial they are recruiting for (assuming he doesn't have another cause):

https://www.clinicaltrials.gov/ct2/show/NCT04601909

I will check into it, thank you!

 

[sami23]

So, it means the Phase 2A trial could be the final trial? Or will it be followed up by a Phase 2B?

I don't think so, that's too premature. But we don't know if the results of the Phase 2a are on another level and beyond what we thought. The important point is the low frequencies, mostly those which encompasses speech. If they can reach it, I think this drug has nothing more to prove.

 

[Aaron91]

I had posted to buy at 21, a month or so ago, but there may be some profit taking until we get closer to new data readouts.

In other words, people selling off stock?

 

[tommyd87]

In other words, people selling off stock?

Yes quite possible. I'm pretty positive if you can take a nearly 100% profit short term and let's say you bought 100 shares or $2100 worth of FREQ shares when @Greg Sacramento indicated. That $2100 would now equate to $4000 so a pretty handy profit.

 

[Whice]

Frequency Therapeutics Inc (FREQ) President and CEO David L. Lucchino Sold $1.5 million of Shares

Interesting...

 

[FGG]

Frequency Therapeutics Inc (FREQ) President and CEO David L. Lucchino Sold $1.5 million of Shares

Interesting...

He still has $13 million or so in shares.

Edit: actually this site says acquired about that many before the sale. Accounting thing? Maybe that's how they pay him on the books.

https://docoh.com/person/1785288/lucchino-david-l

 

[tommyd87]

Frequency Therapeutics Inc (FREQ) President and CEO David L. Lucchino Sold $1.5 million of Shares

Interesting...

This is pretty likely to be a part of the 105b1 trading arrangement that companies like Frequency Therapeutics engage in.

 

[100Hz]

This makes me wonder if CIs would actually help noxacusis in this case because they destroy the sensory cells where the electrodes are placed.

I've started reading a bit more into this, one thing really confuses me though. The cochlear implant seems to get inserted into the Scala Tympani (the lower tunnel) and not the Scala Media (the middle tunnel where the hair cells are). It seems like it would be difficult for the implant to damage the hair cells yet everything I find does say that it is very destructive to what's left. What it seems can happen though is that either the basilar membrane can tear or the implant can deviate into the Scala Media which would both cause damage to structures in the Scala Media.

I just wonder if under the scenario where it was properly inserted into the Scala Tympani with no other damage it would retain any natural hearing?

 

[Diesel]

He still has $13 million or so in shares.

Edit: actually this site says acquired about that many before the sale. Accounting thing? Maybe that's how they pay him on the books.

https://docoh.com/person/1785288/lucchino-david-l

He was probably issued another round of options. It's year-end, so normal to see that.

 

[d'Wooluf]

I just wonder if under the scenario where it was properly inserted into the Scala Tympani with no other damage it would retain any natural hearing?

You may be right. From following a few discussions elsewhere, it seems that there's a significant difference between surgeons. Some are better than others at minimising damage to residual hearing when they do the procedure.

 

[FGG]

I've started reading a bit more into this, one thing really confuses me though. The cochlear implant seems to get inserted into the Scala Tympani (the lower tunnel) and not the Scala Media (the middle tunnel where the hair cells are). It seems like it would be difficult for the implant to damage the hair cells yet everything I find does say that it is very destructive to what's left. What it seems can happen though is that either the basilar membrane can tear or the implant can deviate into the Scala Media which would both cause damage to structures in the Scala Media.

I just wonder if under the scenario where it was properly inserted into the Scala Tympani with no other damage it would retain any natural hearing?


View attachment 42191

From what I understand the insertion itself causes a lot of inflammation that can be more widely destructive to the cochlea.

 

[Christiaan]

Frequency Therapeutics to Host Investor Event on the Potential for Restorative Treatments for Acquired Sensorineural Hearing Loss

WOBURN, Mass.--(BUSINESS WIRE)-- Frequency Therapeutics, Inc. (Nasdaq: FREQ), a clinical-stage biotechnology company focused on harnessing the body's innate biology to repair or reverse damage caused by a broad range of degenerative diseases, today announced plans to host a virtual event and live Q&A session on Tuesday, January 19, 2021 at 8:00 am ET.

Leading researchers and clinicians, along with Company executives, will discuss current interventions for the treatment of acquired sensorineural hearing loss (SNHL), unmet medical needs for hearing loss patients and the potential of FX-322 to transform the current standard of care.

Presenters to include:

• Robert S. Langer, Sc.D., Scientific Co-Founder; Member of Frequency's Board of Directors; David H. Koch Institute Professor, Massachusetts Institute of Technology
• Lawrence R. Lustig, M.D., Chair, Department of Otolaryngology – Head and Neck Surgery, Columbia University
• René H. Gifford, Ph.D., Professor, Hearing and Speech Sciences, Director, Cochlear Implant Program, Vanderbilt University
• Frank Lin, M.D., Ph.D., Director, Cochlear Center for Hearing and Public Health, Johns Hopkins Bloomberg School of Public Health

Event Details:

To join the webcast and live Q&A on Tuesday, January 19, 2021 at 8:00 a.m. ET, please visit the "Investors & Media" section of the Frequency website at www.investors.frequencytx.com. A webcast replay will be archived on the Frequency Therapeutics website for up to 60 days following the event.

 

[FGG]

Frequency Therapeutics to Host Investor Event on the Potential for Restorative Treatments for Acquired Sensorineural Hearing Loss

WOBURN, Mass.--(BUSINESS WIRE)-- Frequency Therapeutics, Inc. (Nasdaq: FREQ), a clinical-stage biotechnology company focused on harnessing the body's innate biology to repair or reverse damage caused by a broad range of degenerative diseases, today announced plans to host a virtual event and live Q&A session on Tuesday, January 19, 2021 at 8:00 am ET.

Leading researchers and clinicians, along with Company executives, will discuss current interventions for the treatment of acquired sensorineural hearing loss (SNHL), unmet medical needs for hearing loss patients and the potential of FX-322 to transform the current standard of care.

Presenters to include:

• Robert S. Langer, Sc.D., Scientific Co-Founder; Member of Frequency's Board of Directors; David H. Koch Institute Professor, Massachusetts Institute of Technology
• Lawrence R. Lustig, M.D., Chair, Department of Otolaryngology – Head and Neck Surgery, Columbia University
• René H. Gifford, Ph.D., Professor, Hearing and Speech Sciences, Director, Cochlear Implant Program, Vanderbilt University
• Frank Lin, M.D., Ph.D., Director, Cochlear Center for Hearing and Public Health, Johns Hopkins Bloomberg School of Public Health

Event Details:

To join the webcast and live Q&A on Tuesday, January 19, 2021 at 8:00 a.m. ET, please visit the "Investors & Media" section of the Frequency website at www.investors.frequencytx.com. A webcast replay will be archived on the Frequency Therapeutics website for up to 60 days following the event.

It should be really interesting to hear Langer speak on this since he is one of the scientists who discovered this process.

 

[Jack V]

It should be really interesting to hear Langer speak on this since he is one of the scientists who discovered this process.

Langer's position with Frequency Therapeutics ("the most cited engineer in history") is one of the things that have given it clout.

 

[serendipity1996]

Langer's position with Frequency Therapeutics ("the most cited engineer in history") is one of the things that have given it clout.

Wasn't he also involved in founding Moderna, which has given us the COVID-19 vaccine too?

 

[sami23]

Why do support hair cells die in profound hearing loss?

 

[Gorbeh3]

Frequency Therapeutics plans HQ move for early next year

More positive news.

 

[FGG]

Why do support hair cells die in profound hearing loss?

That's when they start to die.

Support cells die when you get an epithelial scar of "flat epithelial" which is after extremely severe damage.