Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
- Start date
Didn't your doctor suspect cochlear hydrops in your case (which can cause distortions) or am I thinking of someone else?
Member- Feb 14, 2020
- 1,630
- Tinnitus Since
- 1-2019
- Cause of Tinnitus
- 20+ Years of Live Music, Motorcycles, and Power Tools
Frequency Therapeutics has mentioned in recent research that outer hair cell death is believed to be associated with distorted hearing.
Thank you for the answer! I really hope this is available in the next few years...
- Mar 10, 2020
- 16
- Tinnitus Since
- 8/2018
- Cause of Tinnitus
- acoustic trauma, cochlear hydrops (possibly)
I have this same problem. I took the diuretic and it helped. But I also had an MRI that confirmed I don't have hydrops or Meniere's. I'm not sure what is going on. Might just be a distortion form of tinnitus.
paul mclean
Member
- Sep 8, 2020
- 77
- Tinnitus Since
- 2018
- Cause of Tinnitus
- falling asleep with headphones in on loud
I finally joined Tinnitus Talk, just in time for the big update. This could be it guys! I'm so nervous and so excited.
My panic attacks from tinnitus are gone, now I get panic attacks thinking what if FX-322 doesn't show improvements.
March is a new beginning indeed, we got spring (regeneration) and hopefully news about regeneration of new hair cells.
Btw, thank you for your replies on my question earlier.
If FX-322 doesn't work, I'll go back to unprescribed Prednisone without any choice.
March is a new beginning indeed, we got spring (regeneration) and hopefully news about regeneration of new hair cells.
Btw, thank you for your replies on my question earlier.
If FX-322 doesn't work, I'll go back to unprescribed Prednisone without any choice.
- Aug 5, 2019
- 1,852
- Tinnitus Since
- 05/2019
- Cause of Tinnitus
- Autoimmune hyperacusis from Sjogren's Syndrome
This is a crucial month. I appreciate what Frequency Therapeutics is doing. Hopefully it will somehow reach us non US citizens. If I can't take a plane because of my ears I'll take a boat.
Bill Arsenault
Member
- Mar 31, 2019
- 137
- 53
- Tinnitus Since
- Permanent/Highly intrusive since 2017.
- Cause of Tinnitus
- Noise Over Exposure. Worsened by ototoxic Street Drugs/Meds.
Not so funny how we have to post our Audiograms here to have them interpreted properly as opposed to be being told that all it means is we need hearing aids immediately.
Keith Handy
Member
- Jan 5, 2021
- 302
- Tinnitus Since
- 11/2020
- Cause of Tinnitus
- Stress + sleep deprivation + noise
Just beer bong it into the cochlea... I'm sure it will get deep enough then hehe.
- Sep 21, 2016
- 1,051
- Tinnitus Since
- 2011 - T, 2016- H, relapsed 2019
- Cause of Tinnitus
- noise-induced
- Apr 23, 2019
- 364
- Tinnitus Since
- 04/2019
- Cause of Tinnitus
- Slap to the ear / Leading to more issues after ear surgery
- Mar 6, 2017
- 778
- Tinnitus Since
- 12/2016
- Cause of Tinnitus
- Shooting/loud noise
Frequency Therapeutics themselves have mentioned that SNHL from ototoxic medication is something they are aiming to treat with FX-322. That said, the damage in question needs to be hair cell related of course.
- Aug 5, 2019
- 1,852
- Tinnitus Since
- 05/2019
- Cause of Tinnitus
- Autoimmune hyperacusis from Sjogren's Syndrome
If for some reason, hair cell damage is incurred, then why not? Usually with SSRI, the tinnitus is caused by drug side effects or even a direct result of higher serotonin (a neurotransmitter linked to tinnitus).
- Feb 20, 2021
- 51
- Tinnitus Since
- 10/2019 (mild), 09/2020 (severe)
- Cause of Tinnitus
- SSHL
Out of curiosity: Can't we use the pharmacokinetics model of FX-322 as a basis to assume how deep OTO-413 might reach?
I mean if we compare the typical time for the VPA to reach its peak at ~2 kHz (roughly at 3 hours) and compare it with the slides from OTO-413 from December, where the concentration drops by a factor of 100 within 7 days, we might deduce that OTO-413 can arguably reach below 1 kHz. Vice versa one could start speculating what FX-322 might be capable of if it had the same half time as OTO-413...
I mean if we compare the typical time for the VPA to reach its peak at ~2 kHz (roughly at 3 hours) and compare it with the slides from OTO-413 from December, where the concentration drops by a factor of 100 within 7 days, we might deduce that OTO-413 can arguably reach below 1 kHz. Vice versa one could start speculating what FX-322 might be capable of if it had the same half time as OTO-413...
If you knew the difference in diffusion properties (molecular weights, polarity, etc) between VPA and OTO-413 and factored in the different gels... maybe.
But it might be easier just to ask Otonomy on a podcast if they know how far it goes
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