Hough Ear Institute's Hair Cell Regeneration Project

[Justin De Moss]

No, it was not released because it was ineffective.

In stroke patients it was not effective.

 

[Justin De Moss]

@Justin De Moss
I'm really interested to know what dosage of NAC they use in the pill. Maybe top secret though

A thread was started asking whether someone could make their own Hough Pill: https://www.tinnitustalk.com/thread...0-hough-ear-institutes-bomb-blast-pill.39589/

Top secret. I don't even know

 

[Justin De Moss]

I don't think it will happen anytime soon due to COVID-19. If they started around the same time as FX-322 Phase 2a trial they could have been halfway by now.

Still have no clue why it took them 5 years to get additional funding when they were already done with Phase 1 trials in 2015. They could have been in Phase 3 or releasing the drug out in the market by now.

Funding. It took 5 years to get Oblato on board with taking it through the remaining clinical trials. We had other companies interested as well but Oblato was the first to agree to reasonable terms.

My preference would have been to fundraise for the money for Phase II and then secure even better terms with the pharma company. But that is just me and the way I do business

 

[antonio77]

Justin you have infinite patience

 

[Lucifer]

Funding. It took 5 years to get Oblato on board with taking it through the remaining clinical trials. We had other companies interested as well but Oblato was the first to agree to reasonable terms.

My preference would have been to fundraise for the money for Phase II and then secure even better terms with the pharma company. But that is just me and the way I do business

Thanks Justin for clarifying about how the process went during those 5 years. I did not realise you had other companies that were keen. I always assumed it was only Oblato that was keen to do the clinical trials.

I am not sure if you can answer this or not but when did Oblato start the negotiating process? Was it just recently or have Hough Ear Institute and Oblato been negotiating for many years and it was only recently that you could come to an agreement?

 

[Daniel Lion]

I mentioned it in a previous post. I'll try to find it and re-post it. If I can't I'll get back with the researchers. They know the answer like the back of their hand, whereas I do not and I don't want to mislead you.

Thank you kind sir.

Sincerely, Daniel

 

[Alex0o_o0]

@Justin De Moss first of all, thank you very much for all the time you spend on here answering our question! This is much appreciated and is a real morale booster.

Secondly the POC for objective tinnitus measurement you mention really tickles my curiosity. As you mention yourself, this could mean a huge leap forward in tinnitus research in general. Hence I was wondering if you would be able to provide any information on what exactly we can expect from it, e.g. would it test on loudness, pitch, would it be intended to work for one specific subtype, .... I would totally understand if you cannot provide any info, but one can only try .

Lastly I was wondering if you can provide us with any details on the Peer to Peer funding campaign? Is there any information that is publicly available, such as the final goal, amount still required, ways that we can contribute as individuals, ...

Kr,
Alex

 

[Jurger]

Hi @Justin De Moss, can you give us an update on the injection Hough is developing? Any chance of a Phase 1 study in the near future? Kind regards.

 

[Piney]

So to clarify are we waiting for the proof of concept study to be done, if so when is the estimated completion date? Or are we just waiting for the trials to start this year (6 months in already). I'm just trying to understand where the timeline is. Thanks for the post.

 

[Artemis2K]

I'd like to see if we can get the attention of some well known musicians for this research to see if they'd be willing to donate.

Also, considering what this forum is for, I have a feeling that there are probably lurkers or members that actually know some people that could donate a good amount. Please do consider sharing this thread to whoever.

I'm not entirely sure what the key ingredient HPN-07 is... Can someone explain to me how exactly it exists and how it eventually was discovered to be capable of this?

 

[FGG]

I'm not entirely sure what the key ingredient HPN-07 is... Can someone explain to me how exactly it exists and how it eventually was discovered to be capable of this?

HPN-07 is the name of the ingredient. Here is more about it:

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183089

Apparently it was accidentally later discovered it could help synapses and more chronic cases (a pleasant surprise to Hough, per @Justin De Moss).

 

[Artemis2K]

HPN-07 is the name of the ingredient. Here is more about it:

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183089

Apparently it was accidentally later discovered it could help synapses and more chronic cases (a pleasant surprise to Hough, per @Justin De Moss).

Yo, I don't even remember asking that at 1 AM. xD.

 

[Justin De Moss]

Justin you have infinite patience

I have 7 kids and #8 on the way. God has given me ample opportunities to grow in that virtue. Albeit, God had to take me there kicking and screaming!!!

 

[Justin De Moss]

Thanks Justin for clarifying about how the process went during those 5 years. I did not realise you had other companies that were keen. I always assumed it was only Oblato that was keen to do the clinical trials.

I am not sure if you can answer this or not but when did Oblato start the negotiating process? Was it just recently or have Hough Ear Institute and Oblato been negotiating for many years and it was only recently that you could come to an agreement?

I think we started talking with Oblato about 7 years ago give or take. The process takes a while and different cultures approach things differently. The "Asian" culture, in general, tackles things even more methodically and slowly than we do. That said, Oblato has shared with us their desire to get this moving. But like you, I am cautiously optimistic. When they tell us which indication and the protocol for the Phase II trials - then I'll just be optimistic

 

[Justin De Moss]

@Justin De Moss first of all, thank you very much for all the time you spend on here answering our question! This is much appreciated and is a real morale booster.

Secondly the POC for objective tinnitus measurement you mention really tickles my curiosity. As you mention yourself, this could mean a huge leap forward in tinnitus research in general. Hence I was wondering if you would be able to provide any information on what exactly we can expect from it, e.g. would it test on loudness, pitch, would it be intended to work for one specific subtype, .... I would totally understand if you cannot provide any info, but one can only try .

Lastly I was wondering if you can provide us with any details on the Peer to Peer funding campaign? Is there any information that is publicly available, such as the final goal, amount still required, ways that we can contribute as individuals, ...

Kr,
Alex

Hi Alex,

GREAT NEWS!!!!!!!!!!!

We just got word today that our tinnitus proof of concept study received the grants funds necessary and they were matched. What that means is that we don't need to raise $435,000 anymore. We only need to raise $135,000!!!! Really, because of a generous donor who is willing to match every gift raised for this project - that means we really only need to raise $67,500 in new funds!

Very very doable if the tinnitus community feels strongly enough to make some sacrifice for some real, scientific advancement for treating tinnitus. Not just supporting HEI research but other's as well.

You can find more information here: https://support.houghear.org/hopefortinnitus

Please note that it might take us a while to update the numbers - but we received the $300K so that number will drop appropriately. We are so close! The sooner we can raise that $135,000 the sooner we can get started on the proof of concept study!

Thank you all for your encouragement and support!

Justin De Moss

 

[Justin De Moss]

Hi @Justin De Moss, can you give us an update on the injection Hough is developing? Any chance of a Phase 1 study in the near future? Kind regards.

We are currently fundraising for a Phase I trial and we are in talks with several venture capital firms that have expressed an interest in financing the Phase I and maybe more clinical trials.

 

[Justin De Moss]

So to clarify are we waiting for the proof of concept study to be done, if so when is the estimated completion date? Or are we just waiting for the trials to start this year (6 months in already). I'm just trying to understand where the timeline is. Thanks for the post.

Once the proof of concept study is done, then Phase II studies may be able to be started for the indication of tinnitus. One thing to keep in mind is that we need to understand timelines. For most of us, if we say we will get X done by the end of the week - we do. Sometimes however something comes up and even that gets delayed. One thing I've learned about scientific research is that there are a lot more delays then we like. Primarily because we are suffering and want to see a solution not now, but yesterday or last month!

Phase II could be 1-2 years.

Justin

 

[Justin De Moss]

HPN-07 is the name of the ingredient. Here is more about it:

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183089

Apparently it was accidentally later discovered it could help synapses and more chronic cases (a pleasant surprise to Hough, per @Justin De Moss).

Correct!

 

[Rb86]

FANTASTIC!!!

 

[dan]

@Justin De Moss with all due respect, if NAC is 50% your secret and the other one is just another antioxidant, there is no way you are curing tinnitus... sure perhaps immediately following acoustic trauma antioxidants might help recovery... MIGHT.

NAC does fu$k all for severe chronic tinnitus, it's already been anecdotally proven right here on this forum!

Might as well use HPN-07 + Apple juice...

 

[Justin De Moss]

@Justin De Moss with all due respect, if NAC is 50% your secret and the other one is just another antioxidant, there is no way you are curing tinnitus... sure perhaps immediately following acoustic trauma antioxidants might help recovery... MIGHT.

NAC does fu$k all for severe chronic tinnitus, it's already been anecdotally proven right here on this forum!

Might as well use HPN-07 + Apple juice...

No worries. However, also with all due respect, I'll go with the science and the fact that we just received $300,000 from the state of OK and Oblato, a pharmaceutical company, for a proof of concept study for tinnitus, which includes treating chronic tinnitus. All with the hopes of adding a Phase II clinical study for treating tinnitus. There must be something for NAC and "just another antioxidant" in the data we have already shown to treat tinnitus.

 

[d'Wooluf]

I have 7 kids and #8 on the way. God has given me ample opportunities to grow in that virtue. Albeit, God had to take me there kicking and screaming!!!

Lol @ the 8 kids. I struggle with 2. Btw, with the 8 kids, I don't think God is solely responsible. Just saying. Now get back to those nappies (diapers)!

 

[cjbhab]

@Justin De Moss with all due respect, if NAC is 50% your secret and the other one is just another antioxidant, there is no way you are curing tinnitus... sure perhaps immediately following acoustic trauma antioxidants might help recovery... MIGHT.

NAC does fu$k all for severe chronic tinnitus, it's already been anecdotally proven right here on this forum!

Might as well use HPN-07 + Apple juice...

I agree. My assumption is that they aren't that stupid though. Going to donate tomorrow.

 

[Artemis2K]

@Justin De Moss with all due respect, if NAC is 50% your secret and the other one is just another antioxidant, there is no way you are curing tinnitus... sure perhaps immediately following acoustic trauma antioxidants might help recovery... MIGHT.

NAC does fu$k all for severe chronic tinnitus, it's already been anecdotally proven right here on this forum!

Might as well use HPN-07 + Apple juice...

I am pretty sure it's far more complicated than that. If it was "just another antioxidant", it would not have to go through these rigorous tests, and it'd be available. I believe them when they say that regenerating the synapse was an accident. If they didn't do that, it would not have been reported, because that wasn't the main goal of their drug. Their intention was to preserve hearing, not regenerate it. Their claim of regenerating 15 dB worth of synaptic based hearing is quite an accomplishment, and sense the synaptic ribbons are apparently a major factor in hidden hearing loss and likely tinnitus, I have optimism in their efforts.

 

[Mentos]

@Justin De Moss with all due respect, if NAC is 50% your secret and the other one is just another antioxidant, there is no way you are curing tinnitus... sure perhaps immediately following acoustic trauma antioxidants might help recovery... MIGHT.

NAC does fu$k all for severe chronic tinnitus, it's already been anecdotally proven right here on this forum!

Might as well use HPN-07 + Apple juice...

Give it a chance, if it is proven to restore synapses in rodents then there might be something to it.

 

[dan]

There must be something for NAC and "just another antioxidant" in the data we have already shown to treat tinnitus.

Do you have a link to this Hough Ear Institute study where you show that your pill treats tinnitus?

Seeing is believing, no?

 

[Justin De Moss]

Lol @ the 8 kids. I struggle with 2. Btw, with the 8 kids, I don't think God is solely responsible. Just saying. Now get back to those nappies (diapers)!

Yeah, I think I might have had a little to do with it. Just a little

 

[Justin De Moss]

I agree. My assumption is that they aren't that stupid though. Going to donate tomorrow.

Thank you. Agreed, rarely do people throw money away when their motive is to generate a profit.

 

[Justin De Moss]

I am pretty sure it's far more complicated than that. If it was "just another antioxidant", it would not have to go through these rigorous tests, and it'd be available. I believe them when they say that regenerating the synapse was an accident. If they didn't do that, it would not have been reported, because that wasn't the main goal of their drug. Their intention was to preserve hearing, not regenerate it. Their claim of regenerating 15 dB worth of synaptic based hearing is quite an accomplishment, and sense the synaptic ribbons are apparently a major factor in hidden hearing loss and likely tinnitus, I have optimism in their efforts.

Much better said than me! Thank you.

 

[Justin De Moss]

Give it a chance, if it is proven to restore synapses in rodents then there might be something to it.

Thank you!