Hough Ear Institute's Hair Cell Regeneration Project
- Thread starter all to gain
- Start date
It was said they were in clinical trials with the pill before, but that was years ago.
They are in a proof of concept study, they ask for donations and you can't reach Oblato to ask when the trial is with a 100 ft pole.
They are in a proof of concept study, they ask for donations and you can't reach Oblato to ask when the trial is with a 100 ft pole.
MemberI wish Hough Ear Institute would be more transparent. All of our suspicions could be due to simple misunderstandings. But their silence makes me worry that their drug isn't working the way they thought it would and that they're trying to cover it up.
We should just forget about these guys - if they do produce a breakthrough we'll know about it. If not then we'll not have wasted any time. They'll be last chronologically anyway.
I got an email from Justin De Moss at Hough answering a question I had. In the message he said:
"We have a proof-of-concept study going that is very promising and going quite well. Additionally, we just had out tinnitus research published, and it is making quite the splash. First of its kind and has brought a lot of positive attention as tinnitus is one of our primary research verticals, whereas with others it is a secondary concern.
I checked with our COO and one of our top scientists, and he told me that yes it would be helpful for the inflammation from noise induced acoustic trauma."
I checked with our COO and one of our top scientists, and he told me that yes it would be helpful for the inflammation from noise induced acoustic trauma."
B
buttercake
Guest
Electrophysiological assessment and pharmacological treatment of blast-induced tinnitus. This might be one (January 2021, so yes rather recent). Most of the authors appear in the research staff page of the Hough Ear Institute.
- Feb 10, 2021
- 111
- Tinnitus Since
- 2020
- Cause of Tinnitus
- Acoustic Trauma
Okay I know I am really late to the party on this one, but apparently NHPN-1010 finished its Phase 1 trial back in 2015.
How have they still not finished the Proof of Concept yet for Phase 2? It seems like they are really struggling or something, because they are really taking their time one this one.
How have they still not finished the Proof of Concept yet for Phase 2? It seems like they are really struggling or something, because they are really taking their time one this one.
I think it comes down to funding being a big part of it. However, the mechanisms and methods utilised by Hough Ear Institute to gain funding have simply been quite poor.
- Feb 10, 2021
- 111
- Tinnitus Since
- 2020
- Cause of Tinnitus
- Acoustic Trauma
I only listened to the interview at the end. At around 52 minutes he talks about 3-5 years where people can use it? And starting clinical trials in a couple of years? Not too sure about the wording on that one.
He said that the Phase 2 trial for the Pill will be expensive, at around $10-20 million. The Phase 1 trial was "cheap" apparently at $1 million. They aren't sure whether the Phase 2 trial will be for noise-induced hearing loss, tinnitus or ototoxicity.
The Injection technology is apparently in the preclinical phase while the Pill is at Phase 2.
The sweet spot is at 52 minutes - 57 minutes.
Sorry if my post is confusing. I'm sleepy and it's late lol. After watching it again it appears that this is intended for Acute Acoustic Trauma (24 minutes time stamp). I wonder if it will be too late for us by the time this comes to the market.
- Nov 29, 2014
- 211
- Tinnitus Since
- 10/2007
- Cause of Tinnitus
- Acoustic trauma - Repeated gun blasts
- Feb 10, 2021
- 111
- Tinnitus Since
- 2020
- Cause of Tinnitus
- Acoustic Trauma
- Feb 20, 2021
- 51
- Tinnitus Since
- 10/2019 (mild), 09/2020 (severe)
- Cause of Tinnitus
- SSHL
To explain it very quickly: Some papers showed, that NHPN-1010 increases the BDNF concentration (not sure whether studies where animal studies or on vitro). By this, synaptic growth is enhanced and hidden hearing loss hopefully treated (basically in the same way as OTO-413 intends to). As long as the hair cells and the neurons (with the missing synapses) still exist, it is possible to restore the synaptic connection between these two. It is believed that the neurons do not die for many years or even decades in humans even if they do not receive any input anymore (due to destroyed synapses). Therefore the treatment window only closes if the neurons die.
As a warning though: NHPN-1010 has not been in any clinical trials for efficacy for tinnitus so far and therefore there are only animal or even in vitro studies to rely on. In animal studies where one administered NHPN-1010 more than a month after noise injury it showed normalisation of important biomarkers related to tinnitus.
We do not know so far, whether it will also work in humans and to what extent it does lead to curing hidden hearing loss or tinnitus. As far as I know not even the exact dosing is known. HPN-07 has already been in clinical trials in the mid 2000s to treat ischemic strokes (just like SPI-1005/Ebselen in the 90s) but failed.
Here are a few links as sources:
So I direct messaged Hough Ear Institute's Instagram account and asked:
Me: Any date to start clinical trials?
Hough Ear Institute's Instagram account: We're not sure. We hope in 2023, but we have to assess our data from the two-year proof-of-concept study we began in September of last year and will complete September 1, 2022.
Me: Any date to start clinical trials?
Hough Ear Institute's Instagram account: We're not sure. We hope in 2023, but we have to assess our data from the two-year proof-of-concept study we began in September of last year and will complete September 1, 2022.
- May 29, 2015
- 664
- 30
- Tinnitus Since
- 2012
- Cause of Tinnitus
- I had tinnitus for as long as I can remember. Got bad later.
- Feb 14, 2020
- 1,630
- Tinnitus Since
- 1-2019
- Cause of Tinnitus
- 20+ Years of Live Music, Motorcycles, and Power Tools
frpp
Member
- Sep 17, 2020
- 196
- Tinnitus Since
- 2010
- Cause of Tinnitus
- Tmj, Nihl, ototoxic drugs, nerve/ vascular issues
AfroSnowman
Member
- Jul 23, 2019
- 1,075
- Tinnitus Since
- 04/2019
- Cause of Tinnitus
- Nonnatural energy source
Why would it impact this research? It appears that the FDA has issues with it being sold as a supplement, not with it being sold/used as a prescription drug.
Hopefully Hough Ear Institute pulls through with some success. Last time I spoke with them and read their newsletter they said they think their pill can regrow nerves — providing relief from tinnitus and inflammation of the inner ear from noise exposure.
I'm not expecting anything but I feel like those of us who got noise-induced tinnitus/inflammation have more of an issue with damaged nerves than with hair cell loss, though I'm not an expert and could be wrong on that point.
Either way, I hope for the best and that we can get more updates from them.
I'm not expecting anything but I feel like those of us who got noise-induced tinnitus/inflammation have more of an issue with damaged nerves than with hair cell loss, though I'm not an expert and could be wrong on that point.
Either way, I hope for the best and that we can get more updates from them.
- Dec 30, 2020
- 229
- Tinnitus Since
- 1993, increase in 2020, then new in 2021
- Cause of Tinnitus
- Unsure about the first. Too many beers? Music during sleep.
I've been wondering if there's a way to determine whether one has damaged nerves or hair cell loss or both?
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