I'm thinkin' a little bit of column A, a little bit of column B.Is this just utter incompetence by the people in charge or a big con to try to stay relevant and get more donations?
I'm thinkin' a little bit of column A, a little bit of column B.Is this just utter incompetence by the people in charge or a big con to try to stay relevant and get more donations?
I mean they could have highlighted some of the patients in the Phase 1 trial who had their hearing loss or tinnitus reduce which would have allowed them to sell the rights to NHPN-1010 faster.Would it really be so hard to find investment to push this to market if there was compelling evidence that it worked?
I mean didn't the USA Govt also give them funding? It just makes no sense at all.
Is this just utter incompetence by the people in charge or a big con to try to stay relevant and get more donations? Either way is shocking but I really don't know how things work in the USA.
Where are these study results and what were the outcomes? I can't find them on this thread.I mean they could have highlighted some of the patients in the Phase 1 trial who had their hearing loss or tinnitus reduce which would have allowed them to sell the rights to NHPN-1010 faster.
I don't think they have released the study results out in detail other than stating that Phase 1 was completed and they were going to move onto Phase 2.Where are these study results and what were the outcomes? I can't find them on this thread.
I mean they could have highlighted some of the patients in the Phase 1 trial who had their hearing loss or tinnitus reduce which would have allowed them to sell the rights to NHPN-1010 faster.
Phase I Clinical Trial for a Novel, Orally Available Therapeutic that Addresses Noise-Induced Hearing LossThe medication could also be given prophylactically along with ear plugs when personnel are undergoing extremely loud noise exposure in training. This medication would also be useful in the civilian work force for noise hazardous occupations such as mining, manufacturing, construction, farming, oil-drilling, law enforcement, and others. This medication could also be given to victims with hearing loss after an accidental explosion, loud noise from a deploying automobile air bag, or an explosion from a terrorist attack.
I'm undecided whether I would consider Hough Ear Institute lying about NHPN-1010 working for hearing loss, tinnitus and hyperacusis. It's up to Otologic Pharmaceuticals to either find a buyer or, if they can't find a buyer, they should be testing NHPN-1010 on compassionate use patients who have severe tinnitus and hyperacusis. If they did this, they would be able to find a buyer in no time if the patients' quality of life was much better after getting the treatment.I hate those scammy nonprofits. This world, and particularly this hellhole called United States is fully of greedy vipers that steal from you under guise of doing good. If there is hell, I hope they will get a front row spot in there.
Why would they want to test their "novel" new drug on people with tinnitus or hearing loss BEFORE getting their $500M?if they can't find a buyer, they should be testing NHPN-1010 on compassionate use patients who have severe tinnitus and hyperacusis.
It pisses me off that they did not do speech-in-noise or audiograms in the Phase 1 trial and did not have patients who suffer from hearing loss or tinnitus.
It's up to Otologic Pharmaceuticals (OP) to find a buyer for NHPN-1010. Hough Ear Institute (HEI) can't really do much since they sold the rights to the drug to OP. The heat should really be on OP, and not HEI.Sorry. I don't buy it.
Why would the biggest military complex in the world, the US military, invest $500M in a pill that must be taken continuously in a war zone to protect soldiers' hearing where supply chain may be interrupted and the pills rendered non-deliverable, rather than $500M in a regenerative hearing solution that restores hearing once it's lost.
Hough Ear Institute is a scam. Nothing more. Anybody defending these charlatans is an idiot. Their developers and scientists know absolutely F-all, it's all smoke and mirrors.
On the contrary, sustaining evidence isn't what they need help with. I bet with their current approach, they could rapidly concoct a mountain of evidence consistent with an effective treatment for any hearing-related condition (not excluding tinnitus) at the whiff of profit. That's where the state of scientific methodology is in such decline. If you're lucky, you might get to spend $500 million on a hypothesis backed up by 'testimonies'. Without fettered by empirical rigor even as far as animal studies goes, being oblivious to what the gold standard of 'high-quality evidence' means in academic nomenclature, ignoring even the most basic standards of an observational study, as if the last 50 years of sophistication in rigorous methodology never happened, you might even actually get away with it. (Consumers don't certainly know anything about rigor, as you yourself happen to demonstrate.) Think Frequency Therapeutics. Think Theranos. For me personally, there was one academic write-up (in information technology) which wasn't particularly rewarding given the personnel, while proficient in their field, were indifferent about how you set up your criteria, as long as your observations were linearly consistent with it and in focus. That's no different from how quack science gains credibility. The desperation with which Hough Ear Institute is trying to make themselves appealing to investors suggests they don't have anything to justify $500 million except testimonials which are by definiton low quality evidence or, as implied in the British Medical Journal in the review of Archie Cochran's book Effectiveness and Efficiency: Random Reflections on Health Services (1972):The issue is why would we donate money to Hough Ear Institute? What have they proven their treatment does? They have something they claim is otoPROTECTIVE and at best must be used within hours of acoustic trauma. Show any evidence of benefit to people with chronic tinnitus or hearing loss rather than ONE person's testimony? Show me!
I don't think there is any point in donating more money to Hough Ear Institute or Otologic Pharmaceuticals. I just hope that the next buyer for NHPN-1010 doesn't ask for more money like Oblato.Sometime in late 2019 or early 2020 I donated a modest amount to Hough Ear Institute and several other research organizations (Thanos Tzounopoulos, Susan Shore, Josef Rauschecker).
Since then, Hough Ear Institute has been the only one to consistently/constantly ask for more. I bet they've spent 20% of what I gave them just on postage asking me for another donation. Screams desperation.
I couldn't find any information about it. It's in the pre-clinical stage, so there is a very long way to go.Any estimate when the "regeneration injection AOK-1" will be available? I couldn't find any timeline or update on their website.
Down for me.Is Otologic Pharma website down? Anyone know how long it's been down for?
There's no news of Otologic Pharma (OP) shutting down so could just be they haven't renewed their website or are doing some maintenance.Down for me.