IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

#32
Ian Mac said:
Yeah Pulsatile is not a bid deal, unless it never stops. It's related to your heart which although "involuntary" is actually semi-voluntary, in other words you can control your heart and hence your can control pulsatile T.

The Oxytocin Spray makes me feel like I don't need anything, I just spray it and then sit there feeling warm with no desire to move lol. My T seems slightly quieter and less intense, I will continue to update here.

I also have been diagnosed with Eustacian Tube dysfunction and given steroid nasal spray.. You might have Hydrops, all the fluctuations in your T and hearing sounds like Hydrops symtoms, and drinking water effecting it makes sense too.

How does the Ventilin help your T? increased oxygen into the blood? lower Blood Pressure?
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Prossibly, will have to look into it. Ventilin doesnt help T directly but makes me sleep better, sometime I will wake with sleep aponia(and associted BP spike), with Ventilin I wont. Might give Oxytocin a go.

I measure my BP and it was a insane 170/120!, This morning 150/100. I had 3 bags of potatoes chips (sky high salt intake) and coffee, because I've been avoiding these for months. Little wonder T has spiked.

I'm going to get some BP meds today and will report back when I get some results.
 
#34
XDR said:
Prossibly, will have to look into it. Ventilin doesnt help T directly but makes me sleep better, sometime I will wake with sleep aponia(and associted BP spike), with Ventilin I wont. Might give Oxytocin a go.

I measure my BP and it was a insane 170/120!, This morning 150/100. I had 3 bags of potatoes chips (sky high salt intake) and coffee, because I've been avoiding these for months. Little wonder T has spiked.

I'm going to get some BP meds today and will report back when I get some results.
Click to expand...

FYI when you have hydrops the only recommendations the doctors can give is to avoid caffeine and salt and take a diuretic. I've never noticed caffeine or salt doing anything to my T, food has no effect on my T, and although I've been diagnosed with hydrops I don't actually think I have it, but you are explaining the symptoms, especially the salt and coffee like I said those are the two things I was told to avoid since was diagnosed with hydrops.. The oxytocin spray is nice but don't expect an immidiately dropping T.
 
#35
Ian Mac said:
FYI when you have hydrops the only recommendations the doctors can give is to avoid caffeine and salt and take a diuretic. I've never noticed caffeine or salt doing anything to my T, food has no effect on my T, and although I've been diagnosed with hydrops I don't actually think I have it, but you are explaining the symptoms, especially the salt and coffee like I said those are the two things I was told to avoid since was diagnosed with hydrops.. The oxytocin spray is nice but don't expect an immidiately dropping T.
Click to expand...

Again, you should post about your experience with oxytocin in this thread:
https://www.tinnitustalk.com/threads/the-love-hormone-may-quiet-tinnitus.17618/
 
#36
Ian Mac said:
Pressure.

Vascular- My T sounded like a bird chirping for 1.5 years, in my right ear only. The whole time I had high blood pressure and pulsatile T in both ears. I finally got sleeping again with medications and a hearing aid that masks the bird noise. Pulsatile T of coarse gone, but being able to relax and sleep and masking the bird noise has reduced the Bird Noise dramatically, I believe high blood pressure in the ear was the problem.

Hormonal - Oxytocin Nasal Sprays have been reported to help reduce T, this may be marketing but it seems to make sense given the properties of oxytocin that it could help. I found some on Amazon so who knows but I bought two brands. I will update you if I notice any benefit. I've noticed there is a connection between the Nasal Passage and Hearing/Tinnitus, I think they are Innvervated together. When I had high blood pressure I also was breathing really heavily through my nose and it was "wheezing" and I shit you not the "wheezing" sounded identical to the "Bird Noise" and when I finaly started sleeping again and stopped wheezing through my nose the bird noise T also has almost completely gone away.


Off- Topic but... Good information is good information.

Cochlear - Cochlear Hydrops (increased pressure inside the inner ear (cause unknown)), this pressure causes "fluctuating" tinnitus as the pressure within the Cochlea fluctuates. You wont know if you have hydrops unless you get tested by an otologist, or if you unfortunately develop menieres. Its possible you have Cochlear Hydrops in your hearing chamber. The symptoms are fluctuating hearing loss and Tinnitus as well as vertigo (in most cases but not all) most people with hydrops like me never have such severe pressure that the chamber ruptures causing vertigo and so they never develope full menieres, but they have the precursor called Hydrops and they experience hearing loss and Tinnitus and don't know why. Good news is that you can stop the Hydrops, but they don't know how, probably through diet and exercise. A video on hydrops
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Yes, very good information. This is exactly what the symptoms I have are and what a E-COG ((Electrocochleography) bares out. My E-COG in the right T ear is always in double digits, left ear single digits. My ENT told me if we can get the right in signal digits you're T will go away. Well there have been two occasions where my T was all most undetected, and it just so happened in the four years I have been seeing him my appointment was on that same day, he did an E-COG & both time my right T ear reading was in the signal digit, actually lower that mt good left ear. This does not happen very often where the noise is almost completely gone, but now after reading your comments and seeing the video it all make perfect sense. At least now with a pretty good certainty, I can have a label to put on it.

Thank you
https://www.tinnitustalk.com/url?sa...Xy86NIDvbEayUnruw&sig2=bkgDMFPxqCbx9wYhAZrfuQ
 
#37
#40
Final update

After a whole series of tests and months on IGF1, I can say that the treatment did not work. After a few traumatic life events, my hearing and T is now worse.

Speaking to a neurologist, he agreed that the cause (and cure) is a vascular issue/treatment. IGF1 was a good precautions or stage 1 treatment to regenerate any dead nerve cells but the vascular issue remain. Its about me waiting for next generation MRIs that have the mm resolution to see the damaged blood vessels using radio tracers. Then a surgical treatment can be devised, so its a waiting game until then...
 
#41
XDR said:
Final update

After a whole series of tests and months on IGF1, I can say that the treatment did not work. After a few traumatic life events, my hearing and T is now worse.

Speaking to a neurologist, he agreed that the cause (and cure) is a vascular issue/treatment. IGF1 was a good precautions or stage 1 treatment to regenerate any dead nerve cells but the vascular issue remain. Its about me waiting for next generation MRIs that have the mm resolution to see the damaged blood vessels using radio tracers. Then a surgical treatment can be devised, so its a waiting game until then...
Click to expand...

How did you obtain the IGF-1 and figure out how to do the injections yourself?
 
#42
^ Anti-aging clinics and YouTube.

Logging back in after 2 years. I've done 3 courses of IGF1 since, both acute high dose and long chronic dosage and little to no effect on hearing. If it did work then body builders would have amazing hearing, in reality it's the opposite.

The cure is microsurgery in the vessel supplying the cochlea and not any chemical.
 
#43
A few of my acquaintances have done IGF-1 for bodybuilding purposes. Unfortunately they're total douches, so I don't want to reach out to them.

OP - you got your injections into your arms, yes?
 
#44
XDR said:
^ Anti-aging clinics and YouTube.

Logging back in after 2 years. I've done 3 courses of IGF1 since, both acute high dose and long chronic dosage and little to no effect on hearing. If it did work then body builders would have amazing hearing, in reality it's the opposite.

The cure is microsurgery in the vessel supplying the cochlea and not any chemical.
Click to expand...
It works as an intratympanic injection. I've never seen this thread until now but I am happy to have found it. I too have found ample evidence that this would cure acute stage hearing loss and perhaps work on chronic cases as well. It is implicated in the regeneration of hair cells. The question is why haven't the ATA or BTA brought any attention to this? Possible reasons:
1. They suck at researching and don't know.
2. They think they are geniuses and have made up their minds that it won't work.
3. They actually want to stop people from getting viable treatments and purposefully misguide the course of research.

Can anyone else think of any other possible reason?
 
#45
JohnAdams said:
The question is why haven't the ATA or BTA brought any attention to this?
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From our most recent Tinnitus Talk Podcast episode with David Stockdale from the BTA:

A World Without Tinnitus — David Stockdale (British Tinnitus Association)

Promoting or not promoting upcoming potential treatments (starts at 43:57)
Promoting or not promoting currently available treatments (starts at 52:43)


Further discussion on the podcast episode should go in this thread:

https://www.tinnitustalk.com/threads/episode-2-a-world-without-tinnitus-—-david-stockdale-british-tinnitus-association.33906/
 
#46
JohnAdams said:
It works as an .intratympanic injection I've never seen this thread until now but I am happy to have found it. I too have found ample evidence that this would cure acute stage hearing loss and perhaps work on chronic cases as well. It is implicated in the regeneration of hair cells. The question is why haven't the ATA or BTA brought any attention to this? Possible reasons:
1. They suck at researching and don't know.
2. They think they are geniuses and have made up their minds that it won't work.
3. They actually want to stop people from getting viable treatments and purposefully misguide the course of research.

Can anyone else think of any other possible reason?
Click to expand...
I would not risk an intratympanic injection, too many horror stories. I'd rather flood my body with IGF1 than do that, it's insane risk. Lots of witch doctors offer this, they charge $6,000 for $15 worth of IGF1 and you take the risk. I know people are desperate for a cure but please don't risk making your life insufferable.

I can't speak for BTA or ATA. Working in research I can say funding is an issue as well as bandwagon effects.

Tinnitus requires several fields to find a cure. I strongly suspect it's an overpressurization of the ear due to a micro tear of the vessel causing water hammer (blood hammer). I think a cure would be a stint (flow restricting) being surgically implanted as a cure. So it's surgical and mechanical.
 
#47
Drone Draper said:
A few of my acquaintances have done IGF-1 for bodybuilding purposes. Unfortunately they're total douches, so I don't want to reach out to them.

OP - you got your injections into your arms, yes?
Click to expand...
Lol I never said I wasn't a douche too. I can tell you now they have really bad tinnitus. It's to do with very high blood pressure rupturing the vessel I'm talking about. I did a high dose but they did much higher than I did. And they have worse tinnitus.

In relation to above, IGF1 will heal nerves. It did the wonder job of removing a lot of my aches and pains. Also I look years younger, so it works. But the mechanical failure causing tinnitus remains. A scar will heal quickly but a scar is not gone.

Injections into legs, stomach, arms. I do rotations to make sure the skin doesn't get damaged. I have done hundreds of injections myself since then.
 
#48
XDR said:
I would not risk an intratympanic injection, too many horror stories. I'd rather flood my body with IGF1 than do that, it's insane risk. Lots of witch doctors offer this, they charge $6,000 for $15 worth of IGF1 and you take the risk. I know people are desperate for a cure but please don't risk making your life insufferable.

I can't speak for BTA or ATA. Working in research I can say funding is an issue as well as bandwagon effects.

Tinnitus requires several fields to find a cure. I strongly suspect it's an overpressurization of the ear due to a micro tear of the vessel causing water hammer (blood hammer). I think a cure would be a stint (flow restricting) being surgically implanted as a cure. So it's surgical and mechanical.
Click to expand...
You just made all of that up didn't you?
Name 1 single clinic that offers IGF-1 injections in the eardrum.
 
#49
#50
#53
You started with HGH in July 2016. Did it affect your tinnitus at all? I have tinnitus from sound trauma. Do you think HGH affects me better? And how is your tinnitus now? You still on HGH? I'm a powerlifter so my tinnitus is usually higher the day after working out.
 
#54
XDR said:
Someone sent me a link that you've been commentating on:

https://www.tinnitustalk.com/threads/south-korean-clinic-treatment-dr-minbo-shim.19340/

http://cmclinics.com/

So no I didn't make that up.

Papers I posted used intratympanic injections, 3-6 in total I believe. The course cost me $600, 25 injections, sorry $24 per injection.
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That clinic doesnt inject with IGF-1. They use blood platelets and bone marrow which include many growth factors, not just IGF-1.
XDR said:
I read in thread that the clinic was charging $6000 for the treatment.

I DIY'd the treatment for a fraction of that, same results...
Click to expand...
You DIY'd two weeks of intratympanic injections? That's quite a talent.
 
#55
Terminator said:
You started with HGH in July 2016. Did it affect your tinnitus at all? I have tinnitus from sound trauma. Do you think HGH affects me better? And how is your tinnitus now? You still on HGH? I'm a powerlifter so my tinnitus is usually higher the day after working out.
Click to expand...
I'd probably say little to no effect to be honest. All the salvage treatments had a narrow window of recovery from trauma, Prednisone is the primary (controversial) treatment for SSHL. 2 years after the fact, I doubt it. But if you have the cash why not, I'd recommend IGF1-LR3, it's cheaper but used to treatment for nerve damage. HGH too short a half life and expensive.

Along with HGH and IGF1 I did exercise and looked at ways reducing stress. I'm the same after I do weights or lifting something heavy I get worse tinnitus. To me this effect is directly related to an increase in blood pressure. I made an effort to lose weight and eat healthier, thus reduce blood pressure, so tinnitus is actually better. Now after doing weights the tinnitus doesn't increase as much. One can also experiment with vasodilators, I was on one, can't remember which, common high blood pressure medication that helps reduce tinnitus after exercising. My brother was a pro body builder, he has bad tinnitus, again due to high BP.

Think of tinnitus as inner ear scar tissue, no drug will reverse it. High BP is your enemy, this will dictate how bad it is (also depending on initial trauma)..
 
#56
Hi there! I just read the IGF-1 study you referred to and contacted the research designer to ask if he thinks doctors in Japan would be willing to do this treatment.

I'm not hopeful for a reply so could you point me in the right direction for obtaining the IGF-1? I don't plan on injecting it into my ears and will of course exercise caution with the dosing.

I haven't read about the other drugs you mentioned but would probably also be willing to give them a go.

Thanks for sharing and good luck!
 
#57
Little Lamb said:
Hi there! I just read the IGF-1 study you referred to and contacted the research designer to ask if he thinks doctors in Japan would be willing to do this treatment.

I'm not hopeful for a reply so could you point me in the right direction for obtaining the IGF-1? I don't plan on injecting it into my ears and will of course exercise caution with the dosing.

I haven't read about the other drugs you mentioned but would probably also be willing to give them a go.

Thanks for sharing and good luck!
Click to expand...
Hello Little Lamb,

My name's Daniel.

Injections into the tympanic membrane, or ear, are most effective.

People do it with steroids all the time. Scary, but most effective.

Do you live in Japan?

I live in Laos... Good luck.
 
#58
Little Lamb said:
Hi there! I just read the IGF-1 study you referred to and contacted the research designer to ask if he thinks doctors in Japan would be willing to do this treatment.

I'm not hopeful for a reply so could you point me in the right direction for obtaining the IGF-1? I don't plan on injecting it into my ears and will of course exercise caution with the dosing.

I haven't read about the other drugs you mentioned but would probably also be willing to give them a go.

Thanks for sharing and good luck!
Click to expand...
I have been researching my butt off about all of this since I got tinnitus and I even went to Korea to get a risky procedure involving a large amount of eardrum injections and I am convinced that IGF-1 is the answer. I do not think it is approved for human use in Japan or anywhere, hopefully I am wrong. If you do find a doctor to inject your ears with it keep us posted and good luck!
 
#60
Daniel Lion said:
Hello Little Lamb,

My name's Daniel.

Injections into the tympanic membrane, or ear, are most effective.

People do it with steroids all the time. Scary, but most effective.

Do you live in Japan?

I live in Laos... Good luck.
Click to expand...

Hi Daniel! I live in the USA. I might go to Korea now after reading about the clinic there but it is a long way and a lot of money but I think this is an emergency so I must... I don't know what to do! While in asia it would be a good time to attend some kind of holistic, relaxing mind+body oriented retreat center.
Good luck to you too! Thanks for your message. It's my first post and pretty nice to hear a reply!

JohnAdams said:
I have been researching my butt off about all of this since I got tinnitus and I even went to Korea to get a risky procedure involving a large amount of eardrum injections and I am convinced that IGF-1 is the answer. I do not think it is approved for human use in Japan or anywhere, hopefully I am wrong. If you do find a doctor to inject your ears with it keep us posted and good luck!
Click to expand...

Hi JohnAdams,

How do you do? I must have at first glossed over your post about this clinic in Korea. How marvelous! I'm really pleased to hear that you decided to go for it! I'm casually browsing airfare and lodging. I wish I had seen this sooner!
How did you come to find and trust this clinic and have you discovered any similar ones?
Navigating another country's medical system to find good quality care is a little daunting but I've done it many time before. ‍♀️

How long after T did you start your treatment? I'm four months into both T and H.

Thanks for your message!
 

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