Inner Ear Hair Cell Regeneration — Maybe We Can Know More

#3,122
Totally out of topic but it is not necessary to go public, VCs make money through original investment via ownership, this means that even if the company is not acquired in the future (for big money, thus big profit for them) they still make money from dividends (still i think that there are more money going public BUT dividends are always lower that way)
blah blah... lets find a cure for hearing loss :q
 
#3,123
Iliasp said:
Totally out of topic but it is not necessary to go public, VCs make money through original investment via ownership, this means that even if the company is not acquired in the future (for big money, thus big profit for them) they still make money from dividends (still I think that there are more money going public BUT dividends are always lower that way)
blah blah... lets find a cure for hearing loss :q
Click to expand...
Yes, I have thought same, the early birds want their big d quarterly. But, as competitors arrive it would be prudent to consider a sell off and get out before the market slice is taken, the first to do it will get all the awards, the first to establish a sound clinical affordable model will make the most profit, time and again we see the 3rd, 4th, even 5th arrivals take the market share.
 
#3,126
#3,130
Taylorslay said:
What's everyone's thoughts on the idea that this is possible in the next 15 years?
Click to expand...

No question in my opinion. With the european companies having stage 2 in their sights by the end of 2017 / beginning of 2018, an overly optimistic view would have the procedure out there by 2019 if it were fast tracked, which it is a strong candidate for.

A more realistic view has this on the market in 3-5 years, and a conservative estimate would be 8 at the latest, assuming these treatments are successful with no complications.
 
#3,132
Taylorslay said:
What's everyone's thoughts on the idea that this is possible in the next 15 years?
Click to expand...

Hi, I'm in a bad hearing and tinnitus state at the moment, so I'm not really have the energy to listen to something.
May you mention here, what they mean should be possible in the next 15 years?
Thank you a lot!
 
#3,133
At the moment no one knows if tinnitus, or at least the cases related to inner ear damage...
Click to expand...

Btw., - nobody knows, which cases are related to inner ear damage. Most probably a sudden noise trauma like an explosion is related to inner ear damage. But many T-sufferers had no concrete bang trauma....
 
#3,136
Tinniger said:
Btw., - nobody knows, which cases are related to inner ear damage. Most probably a sudden noise trauma like an explosion is related to inner ear damage. But many T-sufferers had no concrete bang trauma....
Click to expand...


My T is from hearing loss overtime from loud noise exposure. One day my ears just gave way after a long time of loud noise exposure.
 
#3,137
Hearing Loss can have many many causes, loud noise over longer time or even after one time. There must be big differences how people react to noise. It's believed, that it could have a genetical disposition. Another factor could be, when it happens at which time where the inner ear does it's own regeneration.
 
#3,138
Another Swiss based Company with an inner ear drug for treatment of sudden hearing loss.
If all runs fine, they probably have their first drug out at the end of 2019.

www.strekin.com

https://www.wallstreet-online.de/na...her-development-of-str001-sudden-hearing-loss


The latest interview is hold in german language. They also mentioned, that their drug is also working on acute tinnitus.

https://www.strekin.com/images/Press/Dezibel-03_017-Interview-A_Bausch.pdf

https://www.strekin.com/images/Press/20170531-Strekin-PR-Seed-C_def__E.pdf
 
#3,140
jer said:
From what I read I think the drug only focuses on acute hearing loss, or did I not read that correctly?
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Yes, that's correct. It's for acute or sudden hearing loss. So the sooner treatment the better. It doesn't have regenerative potential.
But I would have been very happy when such a treatment had been available after my 2. or third sudden hearing loss.
So I think it's good even for people with Tinnitus or Hearing Problems, because it can happen again....
 
#3,142
jer said:
You are completely right. That would be a very good thing!
Click to expand...
Another good thing for any market proof treatment, it would gain a very lot of money for further research. Otonomy i.e. could use it for it's diclosed 4xx pipeline. As I remember correctly, their founder has also hearing loss and his ultimative goal would be a cure.
 
#3,143
I don't want to appear pessimistic but I did found neither the results of the first clinical trial nor the registration of the second clinical trial in any clinical trial registry platforms.

Morevover, in the interview hold in German, it is mentioned:

"Does the medicine also work against Tinnitus?

There are reasons to believe our drug acts also against acute tinnitus. This hypothesis will be verified in the upcoming phase-three study."
 
#3,144
Frédéric said:
I don't want to appear pessimistic but I did found neither the results of the first clinical trial nor the registration of the second clinical trial in any clinical trial registry platforms.

Morevover, in the interview hold in German, it is mentioned:

"Does the medicine also work against Tinnitus?

There are reasons to believe our drug acts also against acute tinnitus. This hypothesis will be verified in the upcoming phase-three study."
Click to expand...

Hi, this Swiss company uses drug agents which are already on the market for other implications...it's probably a similar tactic like Harvard Researcher Albert Edge did with LGR5+ for hair cell regeneration.
This LGR agent was developed for Alzheimer disease and would be available at Sigma Aldirch company...
So Strekin found something different which might help fir sudden hearung loss.
So probably it runs different than a complete new developed agent (but that's speculation)
Fact abiut phase 3 trial I found here:
https://www.kofam.ch/de/studienportal/studie//38750
 
#3,146
#3,147
 
#3,149
i went to a well respected and very experienced doctor who is an ENT in NY recently and asked about my heavy head and tinnitus. he said most people who get hit numerous times in the head like i did, 1 very severe and 3 other concussions, will have a heavy head feeling. As for the tinnitus, he said he doesnt reaaly medicate patients. He tries to avoid giving people with tinnitus any drugs to see if they lessen the tinnitus. he advised me to get a CI on my other ear and said cell regeneration is in its infancy. it will take lots of trials and many more years even to see anything to help people with chronic tinnitus. its not encouraging at all but it is what it is.
 
#3,150
dan26 said:
i went to a well respected and very experienced doctor who is an ENT in NY recently and asked about my heavy head and tinnitus. he said most people who get hit numerous times in the head like i did, 1 very severe and 3 other concussions, will have a heavy head feeling. As for the tinnitus, he said he doesnt reaaly medicate patients. He tries to avoid giving people with tinnitus any drugs to see if they lessen the tinnitus. he advised me to get a CI on my other ear and said cell regeneration is in its infancy. it will take lots of trials and many more years even to see anything to help people with chronic tinnitus. its not encouraging at all but it is what it is.
Click to expand...

Ofcourse working "hair cell regeneration" would be the AAA solution for hearing loss and therefore it's based on our biggest hope. For myself I also think that it won't be an easy task and I'm sure there will be a lot of obstacles to overcome.
But we never know, discoveries can always be a game changer.
We will see, if the upcoming trials with regenerative potential will give us answers, if there is a minimal enhancement or not.
But yes, there is reason to be cautious with our expectations.
In the otherhand it's very exciting to see what's going on.
 

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