Inner Ear Hair Cell Regeneration — Maybe We Can Know More

[grate_biff]

send to:
MyENTtoldmeIhaveperfecthearing 14
5677 butnevercheckedmyupperhearingrange
Ignorentistan

It´s your claim mate, you should know!

 

[MickV]

So we are talking about that in 20 years we will have a cure? ;(

 

[Aaron123]

Interesting article out of Jian Zuo's lab at St. Jude Children's Research Hospital. They have found a drug called kenpaullone which seems to protect against cisplatin and some noise induced hearing loss. It's a member of a broader class of drugs (CDK2 inhibitors) that seem to have good properties. Time will tell if a statement like "... our discovery of CDK2 inhibitors that act as otoprotectants will probably transform the clinical prevention and treatment of cisplatin ototoxicity and noise-induced hearing loss in patients." will hold up over time. The paper is here: http://jem.rupress.org/content/early/2018/03/06/jem.20172246 (I don't know much about the Journal of Experimental Medicine. It seems to be more of an immunology journal so it seems like a bit of an odd place to publish something like this.) and a press release is here https://www.stjude.org/media-resour...on-possible-drug-to-prevent-hearing-loss.html St. Jude seems to be interested in licensing the development of the drug for hearing: https://www.stjude.org/research/sha...ng-loss-using-cdk2-inhibitors-sj-14-0028.html

Finally, 1) this is a middle ear injection and 2) this is preclinical work in mice and zebrafish so there is no timeline for trials/availability/etc.

 

[tomytl]

Science Article about Progenitor Cell Activation
http://science.sciencemag.org/content/359/6380/1113.3.full

 

[Aaron123]

Science Article about Progenitor Cell Activation

It's an essay Will McLean wrote for a competition. Here's some information: https://www.aaas.org/news/sartorius-science-prize-recognizes-immunotherapy-technology

 

[Codaz]

Interesting article out of Jian Zuo's lab at St. Jude Children's Research Hospital. They have found a drug called kenpaullone which seems to protect against cisplatin and some noise induced hearing loss. It's a member of a broader class of drugs (CDK2 inhibitors) that seem to have good properties. Time will tell if a statement like "... our discovery of CDK2 inhibitors that act as otoprotectants will probably transform the clinical prevention and treatment of cisplatin ototoxicity and noise-induced hearing loss in patients." will hold up over time. The paper is here: http://jem.rupress.org/content/early/2018/03/06/jem.20172246 (I don't know much about the Journal of Experimental Medicine. It seems to be more of an immunology journal so it seems like a bit of an odd place to publish something like this.) and a press release is here https://www.stjude.org/media-resour...on-possible-drug-to-prevent-hearing-loss.html St. Jude seems to be interested in licensing the development of the drug for hearing: https://www.stjude.org/research/sha...ng-loss-using-cdk2-inhibitors-sj-14-0028.html

Finally, 1) this is a middle ear injection and 2) this is preclinical work in mice and zebrafish so there is no timeline for trials/availability/etc.

Here are the papers

 

[Aaron123]

I haven't read the paper yet, but here's a publication from the folks at Hough Ear Institute using siRNA nanoparticles to regenerate hair cells. Will be interesting to see what is actually in the paper. From the abstract, it is very positive that these are results for adult guinea pigs (key here is adult). What isn't clear from the abstract is what "significant" recovery means. Here's a link to the abstract: http://www.cell.com/action/showImagesData?pii=S1525-0016(18)30112-6

 

[Flamingo1]

I haven't read the paper yet, but here's a publication from the folks at Hough Ear Institute using siRNA nanoparticles to regenerate hair cells. Will be interesting to see what is actually in the paper. From the abstract, it is very positive that these are results for adult guinea pigs (key here is adult). Here's a link to the abstract: http://www.cell.com/action/showImagesData?pii=S1525-0016(18)30112-6

Wow! This is big!!

 

[parsky]

I haven't read the paper yet, but here's a publication from the folks at Hough Ear Institute using siRNA nanoparticles to regenerate hair cells. Will be interesting to see what is actually in the paper. From the abstract, it is very positive that these are results for adult guinea pigs (key here is adult). What isn't clear from the abstract is what "significant" recovery means. Here's a link to the abstract: http://www.cell.com/action/showImagesData?pii=S1525-0016(18)30112-6

Hopefully guinea pigs means humans are next. Hough has been working on this for awhile. This is from 2012. http://houghear.org/wp-content/uplo...s-through-Hes1-Hes5-modulation-with-siRNA.pdf

 

[parsky]

I haven't read the paper yet, but here's a publication from the folks at Hough Ear Institute using siRNA nanoparticles to regenerate hair cells. Will be interesting to see what is actually in the paper. From the abstract, it is very positive that these are results for adult guinea pigs (key here is adult). What isn't clear from the abstract is what "significant" recovery means. Here's a link to the abstract: http://www.cell.com/action/showImagesData?pii=S1525-0016(18)30112-6

@Aaron123, were you going to buy a copy of it?

 

[Canadaman]

Why doesn't any of this stuff get tested on primates? If it works on a chimp (or even a monkey) it seems very likely it'd work on a human.

Oh well. I guess it will get tested on primates - humans - during Frequency's stage 2 trial later this year.

 

[Jim51042]

grow but nerves can grow up to an inch in just a month

In the person with typical noise induced loss how long would the typical nerve re-connections need to be?

 

[Jim51042]

Why doesn't any of this stuff get tested on primates

Guinea pigs are really cheap and breed really quickly. My sister and her friend had a play date with 2 pigs they though were both males. In a short amount of time later her friend had more guinea pigs (we ended up taking one of the litter).

So maybe its just a cost thing. Though animal rights group do place more restrictions on chimp testing then they do rodent testing (guinea pigs).

 

[RB2014]

https://www.actiononhearingloss.org.uk/live-well/our-community/our-blog/the-regeneration-game/

No new information, but an article that keeps hearing loss in the spotlight

 

[Codaz]

Why doesn't any of this stuff get tested on primates? If it works on a chimp (or even a monkey) it seems very likely it'd work on a human.

Oh well. I guess it will get tested on primates - humans - during Frequency's stage 2 trial later this year.

Internationally forbidden. Testing on monkeys that is. Germany tested exhaust fumes on monkeys lately and that gave huge media interest: http://www.bbc.com/news/world-europe-42858668

 

[Aaron123]

Internationally forbidden.

No, it isn't. Just with respect to hearing, CGF-166 was tested in rhesus monkeys, and a recent paper by Liberman's lab (https://www.ncbi.nlm.nih.gov/pubmed/28712672) also used rhesus monkeys. Primates are used in research for many other diseases. That said, there are stricter guidelines than on rodents, and monkeys are more expensive.

Germany tested exhaust fumes on monkeys lately and that gave huge media interest

This is true and is completely different.

 

[dpdx]

Cure will probably come out in 2060.

 

[Yusher]

Why they are making such long distance between phases?

 

[Spiral]

Cure will be in 2318 by the time we upload our memory to a machine. Just three hundred years people!!

Dates are useless at this point.

 

[Flamingo1]

Cure will be in 2318 by the time we upload our memory to a machine. Just three hundred years people!!

Dates are useless at this point.

I have an idea! In Support, there is a "Positivity" thread. Why don't you go and start your own thread called the "Negativity" thread and leave this thread for people to post information about ongoing and new research.

 

[Spiral]

I have an idea! In Support, there is a "Positivity" thread. Why don't you go and start your own thread called the "Negativity" thread and leave this thread for people to post information about ongoing and new research.

Lol. The irony... It was a joke!

 

[jeff W]

I haven't read the paper yet, but here's a publication from the folks at Hough Ear Institute using siRNA nanoparticles to regenerate hair cells. Will be interesting to see what is actually in the paper. From the abstract, it is very positive that these are results for adult guinea pigs (key here is adult). What isn't clear from the abstract is what "significant" recovery means. Here's a link to the abstract: http://www.cell.com/action/showImagesData?pii=S1525-0016(18)30112-6

http://linktrack.info/.2s31v

 

[Apolonia]

http://linktrack.info/.2s31v

I can't open this... What does IT say?

 

[parsky]

~10-13dB recovery through direct differentiation of support cells. Not too bad. That's a bit over a 2x improvement in hearing thresholds.

 

[threefirefour]

I have an idea! In Support, there is a "Positivity" thread. Why don't you go and start your own thread called the "Negativity" thread and leave this thread for people to post information about ongoing and new research.

That already exists. It's called My Posting Place.

 

[jeff W]

I was thinking last night that from a business strategy perspective, it may not make much sense for someone (who believes they are ahead of the curve) to publish a new technique/model. What if there are certain labs that don't publish results (for whatever reason) and simply sit back and watch others publish theirs. I am not saying that researchers are money driven (I believe quite the opposite) but we don't always give consideration to the intentions of those that fund such work. I mean who cares about what journal you are in, if you have a biological treatment for hearing loss you are defacto: an overnight superstar. Just a thought.

 

[Dem]

I was thinking last night that from a business strategy perspective, it may not make much sense for someone (who believes they are ahead of the curve) to publish a new technique/model. What if there are certain labs that don't publish results (for whatever reason) and simply sit back and watch others publish theirs. I am not saying that researchers are money driven (I believe quite the opposite) but we don't always give consideration to the intentions of those that fund such work. I mean who cares about what journal you are in, if you have a biological treatment for hearing loss you are defacto: an overnight superstar. Just a thought.

I hope it is like this, seeing that more companies than ever are publishing that they are looking for cure is even more promising that there are also some that are working "underground". Anyway even if all current researches will fail, science is gaining knowledge about hearing problems so quickly that we can hope for cure more than ever.

 

[Champ]

~10-13dB recovery through direct differentiation of support cells. Not too bad. That's a bit over a 2x improvement in hearing thresholds.

Those AREN'T rookie numbers.

 

[Reinier]

~10-13dB recovery through direct differentiation of support cells. Not too bad. That's a bit over a 2x improvement in hearing thresholds.

And as far as I understand, new hair-cels connect (in adult guinea pigs)

 

[rsmcfar]

Good layman's description of the St. Jude's research.

https://cen.acs.org/articles/96/web/2018/03/Small-molecules-shield-mice-against.html