Inner Ear Hair Cell Regeneration — Maybe We Can Know More

[JohnAdams]

As I see curcumine and n-3 PUFA are healing DNA damaged Lgr5 cells and making them working normal. To regenerate colchea we have to make them to work abnormally because some regeneration mechanisms are switched off in mammals. I think thats a problem I had read before that regenerating colchea with markers inhibitors is possible but it is also a cancer risk.

curcumin is very anti-cancer.

 

[PolishSoldier87]

Yes because curcumin and n3pufa are inducing suicide of worn-out or damaged DNA cells like cancer cells.

Now I am taking all this shit for my acoustic trauma and followed by what is weird Augmentin ototoxicity and next followed by Doxy ototoxicity and neurolyme caused by garini burgdorferi which I had got before all this mess and which probably made this mess. For now there is progress with tinnitus, now I almost hear silence in silence but my tinnitus is reactive in noise but no hearing regeneration.

 

[JohnAdams]

Yes because curcumin and n3pufa are inducing suicide of worn-out or damaged DNA cells like cancer cells.

Now I am taking all this shit for my acoustic trauma and followed by what is weird Augmentin ototoxicity and next followed by Doxy ototoxicity and neurolyme caused by garini burgdorferi which I had got before all this mess and which probably made this mess. For now there is progress with tinnitus, now I almost hear silence in silence but my tinnitus is reactive in noise but no hearing regeneration.

man I've got like half of that stuff.

 

[jeff W]

Regrowth of cochlear hair cells is not only associated with notch1 inhibition but also decreased levels of the genes
Hes1, Hes5, Hey1, HeyL, and Jagged1.


The drug that induces hair cell regeneration is a gamma (γ) secretase inhibitor.

"LY411575 is a potent γ-secretase inhibitor"

http://www.selleckchem.com/products/ly-411575.html

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This mail sort of spooked me with respect to that discovery, it was from someone involved with the trials. There is a trial using a related compound in London right now, but I would imagine there are neurological risks.

 

[jeff W]

I think what's needed is a look at hearing loss rates in India where they eat curcumin by the boatload.

rural India has the lowest rates of Alzheimer's on earth.

 

[JohnAdams]

This mail sort of spooked me with respect to that discovery, it was from someone involved with the trials. There is a trial using a related compound in London right now, but I would imagine there are neurological risks.

View attachment 22231

that is the beauty of a natural compound like curcumin, if indeed it can achieve positive results. it seems safe and can already be bought cheaply.

 

[PolishSoldier87]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440695/

"In the present study, curcumin and the other spice components dose-dependently down-regulated presenilin 1 protein, which plays a pivotal role in γ-secretase activity."

 

[IvanRus]

https://www.the-scientist.com/news-opinion/rna-injection-restores-hearing-in-guinea-pigs-30855

 

[JohnAdams]

 

[Hex]

View attachment 22371

How's your T so far?

 

[JohnAdams]

How's your T so far?

Still here. It's been spiked for the last 24 hours or so. I had a good 5 day streak of it being almost gone. Curcumin seems to have an immediate effect to quiet it for me at least. But I dont believe as of now that it can regrow hair cells.

 

[Hex]

Still here. It's been spiked for the last 24 hours or so. I had a good 5 day streak of it being almost gone. Curcumin seems to have an immediate effect to quiet it for me at least. But I dont believe as of now that it can regrow hair cells.

shoot! Sorry to hear that man.
Do you take any other supplements with Curcumin?

Do you know why it spiked?

 

[JohnAdams]

shoot! Sorry to hear that man.
Do you take any other supplements with Curcumin?

Do you know why it spiked?

I take EGCG, CBD oil, codliver oil, and curcumin. That's it.

No idea really why it has spiked. The only correlating factor is that I ran out of Jarrow brand Curcumin and bought Curamed. Either it was just time for a spike or the new curcumin sucks.

 

[tomytl]

positive results usinh stemm cells.


https://www.biospace.com/article/re...ing-cord-blood-to-children-with-hearing-loss/

 

[PDodge]

positive results usinh stemm cells.


https://www.biospace.com/article/re...ing-cord-blood-to-children-with-hearing-loss/

Holy!

 

[Spiral]

positive results usinh stemm cells.
https://www.biospace.com/article/re...ing-cord-blood-to-children-with-hearing-loss/

Hell, I'll volunteer to take the blood of a virgin goat if it works.

 

[PDodge]

positive results usinh stemm cells.


https://www.biospace.com/article/re...ing-cord-blood-to-children-with-hearing-loss/

Where can I get this done?

 

[JohnAdams]

Hell, I'll volunteer to take the blood of a virgin goat if it works.

Well yeah.

 

[JohnAdams]

Where can I get this done?

EXCELLENT QUESTION

 

[Silvio Sabo]

EXCELLENT QUESTION

There are several members of this forum that have had stem cell treatments. There is a rather large thread about it almost at the top of the treatments section.

 

[JohnAdams]

Just called a cord blood bank. You cannot get this treatment in the united states yet.

 

[1000]

Just called a cord blood bank. You cannot get this treatment in the united states yet.

Where then?

 

[PDodge]

Just called a cord blood bank. You cannot get this treatment in the united states yet.

Dam!

 

[JohnAdams]

Inner hair cell regeneration: maybe we can know more,

........if we stop waiting for other people to do this for us. Seriously folks, use google, read the medical journals. Educate yourselves. Help me figure this out. I'm the guinea pig. Help me figure out how to stop curcumin from down regulating histone acetylation. I'm guessing I need to increase levels of histone acetylation transferase while taking curcumin. Kinda scary when you realize what all could go wrong.

 

[1000]

Inner hair cell regeneration: maybe we can know more,

........if we stop waiting for other people to do this for us. Seriously folks, use google, read the medical journals. Educate yourselves. Help me figure this out. I'm the guinea pig. Help me figure out how to stop curcumin from down regulating histone acetylation. I'm guessing I need to increase levels of histone acetylation transferase while taking curcumin. Kinda scary when you realize what all could go wrong.

Are tou going to add Lysine or Arginine?

 

[PolishSoldier87]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092901/

"More recently, a number of other dietary components have been identified which modulate the acetylation state of histones or affect the activities of HDACs and/or histone acetyl transferases [reviewed by Delage and Dashwood (2008)]"

Maybe this article would be usefull.
Delage B, Dashwood RH. Dietary manipulation of histone structure and function. Annu Rev Nutr. 2008;28:347–366. [PMC free article] [PubMed]

 

[JohnAdams]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440695/

"In the present study, curcumin and the other spice components dose-dependently down-regulated presenilin 1 protein, which plays a pivotal role in γ-secretase activity."

Thank you for your research.

I also found this paper.

http://www.cochlea.eu/en/research-lines/regeneration

This better explains the mechanism of notch inhibition. I was dismayed to find that curcumin blocks atoh1 expression but this seems to suggest that when atoh1 is blocked in supporting cells that it accumulates in other cells through a process called lateral inhibition and thus makes hair cells regrow.

 

[JohnAdams]

https://www.sciencedaily.com/releases/2018/04/180404154630.htm


University of Southern California-April 2018
"The researchers designed a molecule combining 7,8-dihydroxyflavone, which mimics a protein critical for development and function of the nervous system, and bisphosphonate, a type of drug that sticks to bones. The pairing of the two delivered the breakthrough solution, the researchers said, as neurons responded to the molecule, regenerating synapses in mouse ear tissue that led to repair of the hair cells and neurons, which are essential to hearing."

About
https://examine.com/supplements/7-8-dihydroxyflavone/

What's up with that?​

 

[PolishSoldier87]

https://www.amazon.com/Modular-Series-Model-Number-Dihydroxyflavone/dp/B00O5N69EY

Wanna try with curcumin? Maybe Nobel prize is just around the corner.

 

[JohnAdams]

https://www.amazon.com/Modular-Series-Model-Number-Dihydroxyflavone/dp/B00O5N69EY

View attachment 22409

Wanna try with curcumin? Maybe Nobel prize is just around the corner.

Me and you are on the same wavelength. I seriously doubt the Nobel Prize would be coming our way.