Inner Ear Hair Cell Regeneration — Maybe We Can Know More

[PolishSoldier87]

Inner Ear Hair Cell Damage — Maybe We Can Know More

I would be glad to know, whether my tinnitus is due to inner ear cell damage, - or not.
If not, I don't need any hair cell regeneration....

Just check your hair cells by doing OAE test.

I find it very improbable that something would cause neurological damage but only in one specific region of the brain that's really far from the ears.

One specific brain region where all cranial nerves are rooted. Spinal cord and other nerves provide most of information by it. Brainstem contain 3/4 of all neurons in brain and is very susceptible to all kind of toxins. In damaged or brang in hiperactivity mode (f.ex by wrong input from hair cells) brainstem can occur wrong couplings and connections between nucleuses causing tinnitus, visual snow, vestibular problems, hearing loss etc. For me, very probable.

 

[FGG]

Just check your hair cells by doing OAE test.


One specific brain region where all cranial nerves are rooted. Spinal cord and other nerves provide most of information by it. Brainstem contain 3/4 of all neurons in brain and is very susceptible to all kind of toxins. In damaged or brang in hiperactivity mode (f.ex by wrong input from hair cells) brainstem can occur wrong couplings and connections between nucleuses causing tinnitus, visual snow, vestibular problems, hearing loss etc. For me, very probable.

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For those of us with this type of damage, what do you suppose our best hope is? Also, can any spontaneous healing occur in this area?

 

[JohnAdams]

Just check your hair cells by doing OAE test.


One specific brain region where all cranial nerves are rooted. Spinal cord and other nerves provide most of information by it. Brainstem contain 3/4 of all neurons in brain and is very susceptible to all kind of toxins. In damaged or brang in hiperactivity mode (f.ex by wrong input from hair cells) brainstem can occur wrong couplings and connections between nucleuses causing tinnitus, visual snow, vestibular problems, hearing loss etc. For me, very probable.

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View attachment 31076

Glad to see you're still around good friend.

 

[PolishSoldier87]

For those of us with this type of damage, what do you suppose our best hope is? Also, can any spontaneous healing occur in this area?

I think spontaneus regeneration is possible but it is a long process in case of central hearing loss. Maybe something natural but i did not find any crucial herbs yet.
Maybe stem cells will help in the future.

Stimulation of synapse formation between stem cell-derived neurons and native brainstem auditory neurons.
"This study developed novel methods to co-culture neural stem cell-derived spiral ganglion-like neurons (ScNs) and mouse auditory cochlear nucleus (CN) neurons to understand whether ScNs of the peripheral nervous system (PNS) synapse with CN neurons of the central nervous system (CNS) (...)
These results reveal that stem cell-derived PNS neurons are able to form functional connections with native CNS neurons, which is critical for stem cell-based neural pathway regeneration."
https://www.nature.com/articles/s41598-017-13764-8

Maybe strong psychodelics like LSD or DMT would help but who knows. You are abnormal MAO so it can be not the smartest idea.

Psychedelics Promote Structural and Functional Neural Plasticity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082376/

Psychedelic Drugs May Change the Structure of Brain Cells
https://www.livescience.com/62802-psychedelic-drugs-change-nerve-cells.html

We Have The Best Evidence Yet That Psychedelic Drugs Can Repair Broken Neural Networks
https://www.sciencealert.com/psychedelic-drugs-mdma-lsd-repair-broken-neural-networks-in-brain


In the case of tinnitus my theory is that we need something that would reset the mode of work of brainstem or help to ignore false inputs.

Glad to see you're still around good friend.

Hi, friend!

 

[PolishSoldier87]

For those of us with this type of damage, what do you suppose our best hope is? Also, can any spontaneous healing occur in this area?

I think long term use of big doses of CBD can be very useful. It protects and regenerates the brain's neurons and increases BDNF factor.

 

[FGG]

I think long term use of big doses of CBD can be very useful. It protects and regenerates the brain's neurons and increases BDNF factor.

Anyone know if regenerated neurons can regenerate new synaptic potassium ion channels or if they reuse the same ones?

 

[PolishSoldier87]

Anyone know if regenerated neurons can regenerate new synaptic potassium ion channels or if they reuse the same ones?

What's the difference?

 

[FGG]

What's the difference?

For me, at least, there is a huge difference. My neurons are otherwise normal in my brain stem but certain ototoxins can bind to and then deform the potassium ion channels (in my case kv3.1). New neurons using the same deformed channels would do zero to help my hearing unless there were new channels formed, too.

 

[PolishSoldier87]

For me, at least, there is a huge difference. My neurons are otherwise normal in my brain stem but certain ototoxins can bind to and then deform the potassium ion channels (in my case kv3.1). New neurons using the same deformed channels would do zero to help my hearing unless there were new channels formed, too.

New neurons using deformed channels of old neurons? Is this even possible?

 

[JohnAdams]

For me, at least, there is a huge difference. My neurons are otherwise normal in my brain stem but certain ototoxins can bind to and then deform the potassium ion channels (in my case kv3.1). New neurons using the same deformed channels would do zero to help my hearing unless there were new channels formed, too.

If they are new doesn't that mean they are new?

 

[JohnAdams]

New neurons using deformed channels of old neurons? Is this even possible?

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Have you found anything else new? I'm taking 7,8 DHF and curcumin.
I'm thinking I have disregulated TRKB receptors.

 

[PolishSoldier87]

The problem is in the potassium channels of the synapses that are between any given neuron chain and the rest of the nervous system. We should ask some specialist about that who knows how the process of the neuro and synaptogenesis and synaptoplasticity according to KV channels appears and what is going to happen with old, damaged neurons and synapses during this process.

KV channels play a crucial role in synapse regeneration process.

 

[PolishSoldier87]

Have you found anything else new? I'm taking 7,8 DHF and curcumin.
I'm thinking I have disregulated TRKB receptors.

Why do you think that?

 

[JohnAdams]

Why do you think that?

Because I was on blood thinners the night this started. That can thin out the blood and I read that anoxia can cause a disruption of TRKB signaling also curcumin can influence TRKB signaling and when I take a lot of curcumin it silences my tinnitus.

 

[PolishSoldier87]

Because I was on blood thinners the night this started. That can thin out the blood and I read that anoxia can cause a disruption of TRKB signaling also curcumin can influence TRKB signaling and when I take a lot of curcumin it silences my tinnitus.

Didn't you have acoustic trauma?

 

[JohnAdams]

Didn't you have acoustic trauma?

Yes. And too much aspirin, and about 6 hours of sex. All in the night before this started.

 

[PolishSoldier87]

Yes. And too much aspirin, and about 6 hours of sex. All in the night before this started.

And you cured your tinnitus with curcumin?

 

[PolishSoldier87]

@tarmaced it is not so funny if I tell you that I had pneumatic drills in my ears when I was on doxycycline for treating Lyme's disease. I had eaten 5-10g curcumin daily month by month and the tinnitus kept fluctuating, but overall it was fading. I remember that it was very quiet and I heard it only in silent places when I started to eat big doses of CBD. Second day I took a big dose under tongue and after 10 mins I drank i water. Next day I had complete silence. I used to eat all this stuff to this day and continue to do this because my ears still have some strange behaviours but I have more or less normality and I come back to this forum only because maybe I would help someone.

Herbs like curcumin and CBD strongly affect the brain's neural regeneration by affecting NGF, IGF1 and BDNF. Moreover they are strongly anti-cancer. Just killing cancer cells.

If you are interested in this topic I can provide research sources and more information.

 

[JohnAdams]

And you cured your tinnitus with curcumin?

I am not cured. I think you and I could collaborate on more research though.

 

[PolishSoldier87]

I am not cured.

Say at least that it's better than year ago...

 

[FGG]

The problem is in the potassium channels of the synapses that are between any given neuron chain and the rest of the nervous system. We should ask some specialist about that who knows how the process of the neuro and synaptogenesis and synaptoplasticity according to KV channels appears and what is going to happen with old, damaged neurons and synapses during this process.

KV channels play a crucial role in synapse regeneration process.

I'm worried this means it's hopeless for me .

 

[tarmaced]

@tarmaced it is not so funny if I tell you that I had pneumatic drills in my ears when I was on doxycycline for treating Lyme's disease. I had eaten 5-10g curcumin daily month by month and the tinnitus kept fluctuating, but overall it was fading. I remember that it was very quiet and I heard it only in silent places when I started to eat big doses of CBD. Second day I took a big dose under tongue and after 10 mins I drank i water. Next day I had complete silence. I used to eat all this stuff to this day and continue to do this because my ears still have some strange behaviours but I have more or less normality and I come back to this forum only because maybe I would help someone.

Herbs like curcumin and CBD strongly affect the brain's neural regeneration by affecting NGF, IGF1 and BDNF. Moreover they are strongly anti-cancer. Just killing cancer cells.

If you are interested in this topic I can provide research sources and more information.

Not that kind of funny. I have kept tabs on these discussions and take 3g a day.

No benefit for me yet, alas, but given the topic of this thread... The hope that a herb will do the trick for us tickles my blacker sense of humor.

No offense meant

Especially to someone here to help!

 

[TomBradyGOAT]

Yes. And too much aspirin, and about 6 hours of sex. All in the night before this started.

6 hours!!!!! Wow. I am really out of shape. I am not by fast to the draw but definitely couldn't last that long. I would need oxygen and an ER visit if I tried to last that long. Props to you.

 

[Juan]

For me, at least, there is a huge difference. My neurons are otherwise normal in my brain stem but certain ototoxins can bind to and then deform the potassium ion channels (in my case kv3.1). New neurons using the same deformed channels would do zero to help my hearing unless there were new channels formed, too.

How can you get that sort of diagnosis?

 

[JohnAdams]

Say at least that it's better than year ago...

Yeah but I also went to that Minbo Shim doctor and got an assload of bone marrow and PRP injected into my ears and I'm not 100% sure if that did or didn't do anything.

 

[Bndsmheowqhe]

Yeah but I also went to that Minbo Shim doctor and got an assload of bone marrow and PRP injected into my ears and I'm not 100% sure if that did or didn't do anything.

I thought it was working.

 

[Jazzer]

Yeah but I also went to that Minbo Shim doctor and got an assload of bone marrow and PRP injected into my ears and I'm not 100% sure if that did or didn't do anything.

Wow - John.

I believe the last time I asked you what your assessment of the tinnitus noise reduction was, you estimated about 90% - please correct me if I've got that wrong bud.

Your current view is surely a let down.
If so I'm so sorry my friend.

 

[scotty03874]

Yeah but I also went to that Minbo Shim doctor and got an assload of bone marrow and PRP injected into my ears and I'm not 100% sure if that did or didn't do anything.

Hello John,

You have very little hearing loss. Were you hoping for the tinnitus to only subside or also getting your hearing back to perfect? My right ear has hearing loss from a slap on 7th April, 2019. Attached is my recent hearing test. Do you think I should wait a bit longer if I was to go see the doctor?? Money isn't an issue for me. I just want some advice...

 

[JohnAdams]

I thought it was working.

Wow - John.

I believe the last time I asked you what your assessment of the tinnitus noise reduction was, you estimated about 90% - please correct me if I've got that wrong bud.

Your current view is surely a let down.
If so I'm so sorry my friend.

No dudes. My tinnitus has certainly much lower, but I've also been taking 7,8 DHF and curcumin off and on. I said this previously, I cannot be certain whether my improvement was from time, 7,8 DHF, curcumin, or PRP injections, or some combination. It would be dishonest for me to say for a certainty that I have improved from the PRP.
I'm honestly thinking it was the curcumin taking down some inflammation and allowing a degree of healing to occur.
How can I possibly know? I do know that my improvements coincided with the end of the PRP torture. I wish I could say for a certainty.

 

[Bndsmheowqhe]

No dudes. My tinnitus has certainly much lower, but I've also been taking 7,8 DHF and curcumin off and on. I said this previously, I cannot be certain whether my improvement was from time, 7,8 DHF, curcumin, or PRP injections, or some combination. It would be dishonest for me to say for a certainty that I have improved from the PRP.
I'm honestly thinking it was the curcumin taking down some inflammation and allowing a degree of healing to occur.
How can I possibly know? I do know that my improvements coincided with the end of the PRP torture. I wish I could say for a certainty.

What brand 7,8 DHF?