Inner Ear Hair Cell Regeneration — Maybe We Can Know More

On top of that, CIs do not cover the full hearing range. If they did, I think they would be even more effective. They are working on light-based (vs electrical based) CIs now which should have better frequency coverage.
Man, if we all got tinnitus in 2030, we could choose our treatments from a menu card.
 
Strekin AG Completes Phase 3 Clinical Study of STR001 to Restore Hearing in Patients with SSNHL

Strekin AG, a Swiss-based biopharmaceutical company focused on developing new treatments to reverse hearing loss, has completed its Phase 3 clinical trial of the investigational drug STR001 in patients with Sudden Sensorineural Hearing Loss (SSNHL).

If the results are promising, STR001 could become the first approved treatment for SSNHL patients.

Source:
https://clinicaltrials.gov/ct2/show/NCT03331627?type=Intr
 
Strekin AG Completes Phase 3 Clinical Study of STR001 to Restore Hearing in Patients with SSNHL

Strekin AG, a Swiss-based biopharmaceutical company focused on developing new treatments to reverse hearing loss, has completed its Phase 3 clinical trial of the investigational drug STR001 in patients with Sudden Sensorineural Hearing Loss (SSNHL).

If the results are promising, STR001 could become the first approved treatment for SSNHL patients.

Source:
https://clinicaltrials.gov/ct2/show/NCT03331627?type=Intr
This is good news for acute cases but, unfortunately, it isn't useful for chronic cases.
 
Strekin AG Completes Phase 3 Clinical Study of STR001 to Restore Hearing in Patients with SSNHL

Strekin AG, a Swiss-based biopharmaceutical company focused on developing new treatments to reverse hearing loss, has completed its Phase 3 clinical trial of the investigational drug STR001 in patients with Sudden Sensorineural Hearing Loss (SSNHL).

If the results are promising, STR001 could become the first approved treatment for SSNHL patients.

Source:
https://clinicaltrials.gov/ct2/show/NCT03331627?type=Intr
Do they have a website?
 
Strekin AG Completes Phase 3 Clinical Study of STR001 to Restore Hearing in Patients with SSNHL

Strekin AG, a Swiss-based biopharmaceutical company focused on developing new treatments to reverse hearing loss, has completed its Phase 3 clinical trial of the investigational drug STR001 in patients with Sudden Sensorineural Hearing Loss (SSNHL).

If the results are promising, STR001 could become the first approved treatment for SSNHL patients.

Source:
https://clinicaltrials.gov/ct2/show/NCT03331627?type=Intr
Awesome news but, correct me if I'm wrong, this drug is only effective for noise induced hearing loss acquired in a 96 hour timeline. So extremely acute cases.

I got really excited as I haven't heard of this company or drug and completing phase 3 sounds really promising. But I'm nearing a year into tinnitus from noise induced hearing loss.
 
Strekin AG Completes Phase 3 Clinical Study of STR001 to Restore Hearing in Patients with SSNHL

Strekin AG, a Swiss-based biopharmaceutical company focused on developing new treatments to reverse hearing loss, has completed its Phase 3 clinical trial of the investigational drug STR001 in patients with Sudden Sensorineural Hearing Loss (SSNHL).

If the results are promising, STR001 could become the first approved treatment for SSNHL patients.

Source:
https://clinicaltrials.gov/ct2/show/NCT03331627?type=Intr


This looks great!
 
Strekin AG Completes Phase 3 Clinical Study of STR001 to Restore Hearing in Patients with SSNHL

Strekin AG, a Swiss-based biopharmaceutical company focused on developing new treatments to reverse hearing loss, has completed its Phase 3 clinical trial of the investigational drug STR001 in patients with Sudden Sensorineural Hearing Loss (SSNHL).

If the results are promising, STR001 could become the first approved treatment for SSNHL patients.

Source:
https://clinicaltrials.gov/ct2/show/NCT03331627?type=Intr
Is this only for hearing loss in the acute stage?
 
This is good news for acute cases but, unfortunately, it isn't useful for chronic cases.
Completed phase 3 trial sounds like they have made it quite far. Why it is only for the acute cases? Looks like some hearing regeneration drug as FX-322.
 
Completed phase 3 trial sounds like they have made it quite far. Why it is only for the acute cases? Looks like some hearing regeneration drug as FX-322.
It's not a regenerative drug. It's an anti-oxidant that prevents acute injury from leading to permanent damage.

And from their trial inclusion requirements from clinicaltrials.gov:

Inclusion Criteria:

  1. Male or female patients aged ≥ 18
  2. Patients with a SSHL within 96 hours of its perception
Within 96 hours is for very acute cases.
 
More promising research on auditory nerve regeneration: https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/stem.3181
Albert Edge is one of the authors.
Lin-28 reprograms inner ear glia to a neuronal fate: possibility of a new avenue for regeneration that could replace dying neurons in auditory neuropathy.
But how could the auditory nerve be damaged? Only through acoustic neuroma, some drug or maybe some badly run surgery. Probably most have tinnitus and hyperacusis noise induced and so fixing hair cells would be enough. And these new approaches FX-322, Audion, HEI don't seem to use stem cells which is even better because I think the cancer problem with stem cells was never solved.
 
But how could the auditory nerve be damaged? Only through acoustic neuroma, some drug or maybe some badly run surgery. Probably most have tinnitus and hyperacusis noise induced and so fixing hair cells would be enough. And these new approaches FX-322, Audion, HEI don't seem to use stem cells which is even better because I think the cancer problem with stem cells was never solved.
I assume this could have implications for cochlear synaptopathy.
 
Okay, so someone with perfectly fine audiogram nevertheless having tinnitus and hyperacusis might suffer from cochlear synaptopathy and the hearing regeneration drugs might not have any positive effect at all since there is no major loss of hair cells. I hope they make some progress also in diagnostic tests to check what's actually damaged in our ears.
 
More promising research on auditory nerve regeneration: https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/stem.3181
Albert Edge is one of the authors.
Lin-28 reprograms inner ear glia to a neuronal fate: possibility of a new avenue for regeneration that could replace dying neurons in auditory neuropathy.
This seems like it would be especially good news for those with Auto-immune auditory neuropathies.
Okay, so someone with perfectly fine audiogram nevertheless having tinnitus and hyperacusis might suffer from cochlear synaptopathy and the hearing regeneration drugs might not have any positive effect at all since there is no major loss of hair cells. I hope they make some progress also in diagnostic tests to check what's actually damaged in our ears.
OTO-413, and Hough pill are both synaptopathy drugs. PIPE-505 in pre-clinical is also.

Hair cell regeneration drugs will not effect cochlear synaptopathy but synapse regeneration drugs should.

But agree, better diagnostics are sorely needed.
 
Add FX-322 to this list also.
Does FX-322 also help with cochlear synaptopathy? What is definitely on the positive side for the Hough pill and Pipeline is that they explicitly mention tinnitus. Hopefully they receive enough funding to push these drugs through the clinical trial phases, so that we have not years of endless waiting ahead of us.
 
Does FX-322 also help with cochlear synaptopathy? What is definitely on the positive side for the Hough pill and Pipeline is that they explicitly mention tinnitus. Hopefully they receive enough funding to push these drugs through the clinical trial phases, so that we have not years of endless waiting ahead of us.
It's not a synaptopathy drug specifically but, as far as we know, it does restore the synapse *if* its corresponding hair cell is damaged.
 
I just came across this post from Action on Hearing Loss.
https://www.actiononhearingloss.org...auditory-nerve-underlies-hidden-hearing-loss/
Researchers at UCL were looking into developing diagnostic tests for hidden hearing loss/cochlear synaptopathy. This project spanned Feb 2016-2019. I know the issue of inadequate diagnostics gets brought up a lot on this forum - I'll investigate and see if there's any news as to what came out of it.

EDIT: Okay so this project is still listed under currently funded projects and is dated 2017-20.
 
I just came across this post from Action on Hearing Loss.
https://www.actiononhearingloss.org...auditory-nerve-underlies-hidden-hearing-loss/
Researchers at UCL were looking into developing diagnostic tests for hidden hearing loss/cochlear synaptopathy. This project spanned Feb 2016-2019. I know the issue of inadequate diagnostics gets brought up a lot on this forum - I'll investigate and see if there's any news as to what came out of it.

EDIT: Okay so this project is still listed under currently funded projects and is dated 2017-20.
They seem to be using synaptopathy and neuropathy interchangeably there unless that's just how Action on Hearing Loss is reporting it.
 
They seem to be using synaptopathy and neuropathy interchangeably there unless that's just how Action on Hearing Loss is reporting it.
Yeah that's actually something that I noticed and I'm a bit confused as some sources seem to use these phrases interchangeably but I think there's some distinction between them?
 

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